Correlation of Serum Androgens and Pituitary Hormone Levels with Serum PSA Less Than 2.5 NG/ML

Abstract

The aim of this clinical study was to determine whether there is a relationship between total serum testosterone, free testosterone, FSH (Follicle-Stimulating Hormone), LH (Luteinizing Hormone) and serum prostate specific antigen (PSA) levels. We postulated that such a correlation existed then the use of hormone specific reference ranges might enhance the usefullness of PSA concentrations <2.5 ng/mL as a marker for prostate cancer.Prior to digital rectal examination, serum was obtained from all patients between 8.30-10:00 AM for hormone and PSA concentrations. The study was performed on 210 male patients >40 years of age visiting our urology outpatient clinics. PSA was correlated to age (r = 0.23, p = 0.019), but there none between serum testosterone and age. No significant correlation was noted between testosterone or free testosterone and serum PSA levels, and none between serum FSH or LH and PSA. In age specific reference groups (41-49; 50-59; 60-69 years), we found no significant correlation between PSA and hormone concentrations.In this population of eugonadal men with serum PSA values less than 2.5 ng/ml, serum androgens and pituitary hormones do not appear to correlate with serum PSA.

Body Composition, Abdominal Fat Distribution, and Prostate-Specific Antigen Test Results

“…However, the evidence linking circulating androgens to circulating PSA levels is scant. Some studies have shown PSA production to be under androgenic control (31) or associated with testosterone (32)(33)(34), although other studies have found no association at all (35,36).…”

The association of pathogenic factors of metabolic syndrome on serum prostate-specific antigen levels: a pilot study

“…Sofikerim et al [24] analyzed 210 subject whose serum PSA level was less than 2.5 ng/ml and pointed out that there was no significant correlation between the serum PSA level with the serum testosterone and serum free testosterone concentration. A similar study demonstrated that there was no linear correlation between the serum testosterone concentration and the serum PSA level, and testosterone replacement therapy did not cause changes in the serum PSA level [25].…”

The Prognostic Value of Pathologic Prostate-specific Antigen Mass Ratio in Patients With Localized Prostate Cancer With Negative Surgical Resection Margins

“…12,[15][16][17] However, some studies have shown no association between PSA production and endocrine disturbances such as low testosterone level. 17,18 Several studies have also proposed a volume-dilution theory to explain serum PSA concentration. 5,17 This theory posits that, because higher BMI is associated with higher plasma volume, hemodilution might result in lower serum PSA concentrations among obese men with prostate cancer.…”