Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions

Bhattacharjee, Abhinandan; Giri, Sarbani; Roy, Mainak; Chakraborty, Adity

doi:10.4103/0973-1482.172718

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…As the serum levels of ALT, AST, ALP and LDH are major hepatic enzymes, we measured their level in order to evaluate how SS could affect the HFC diet-induced hepatocellular abnormality ( Figure 3 A–D). AST and ALT are biomarkers of liver injury, while ALP and LDH are markers of tumor cell differentiation and necrosis, respectively [ 49 ]. As expected, significant increases in serum ALT, AST, ALP and LDH levels were detected in the HFC group.…”

Section: Discussionmentioning

confidence: 99%

Stachys sieboldii Miq. Root Attenuates Weight Gain and Dyslipidemia in Rats on a High-Fat and High-Cholesterol Diet

Lee

Kim

et al. 2020

Nutrients

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This study aimed at investigating the anti-obesity and anti-dyslipidemic effects of Stachys sieboldii Miq. root (SS) powder in rats following a high-fat and high-cholesterol (HFC) diet for 6 weeks. Thirty-two Sprague–Dawley rats were fed one of the following diets: a regular diet (RD), HFC, HFC supplemented with 3% SS (HFC + 3SS) or HFC supplemented with 5% SS (HFC + 5SS). Following an HFC diet increased body weight (BW) gain (p < 0.001) and the food efficiency ratio (FER; p < 0.001); however, SS consumption gradually prevented the HFC-induced BW gain (p < 0.001) and increase in FER (p < 0.01). The HFC diet resulted in increased liver size (p < 0.001) and total adipose tissue weight (p < 0.001), whereas the SS supplementation decreased hepatomegaly (p < 0.05) and body fat mass (p < 0.001). SS consumption prevented the increased activities of serum alanine aminotransferase (ALT; p < 0.001), aspartate aminotransferase (AST; p < 0.001), alkaline phosphatase (ALP; p < 0.01 in HFC + 5SS) and lactate dehydrogenase (LDH; p < 0.001 in HFC + 5SS) induced by the HFC diet (p < 0.001). The SS supplementation improved lipid profiles in the circulation by lowering triglyceride (TG; p < 0.01), total cholesterol (TC; p < 0.001) and non-HDL cholesterol (non-HDL-C; p < 0.001) levels, as well as the atherogenic index (p < 0.01) and cardiac risk factor (p < 0.01). The lipid distribution in the liver (p < 0.05) and white adipose tissues (WAT; p < 0.001) of the HFC + SS diet-consuming rats was remarkably lower than that of the HFC diet-consuming rats. The average size of the epididymal adipose tissue (p < 0.001) was significantly lower in the HFC + SS diet-fed rats than in the HFC diet-fed rats. The fecal lipid (>3% SS; p < 0.001) and cholesterol (5% SS; p < 0.001) efflux levels were significantly elevated by the SS supplementation compared to those measured in the RD or HFC diet-fed groups. In addition, the hepatic lipid and cholesterol metabolism-related gene expressions were affected by SS consumption, as the hepatic anabolic gene expression (Acc; p < 0.001, Fas; p < 0.001 and G6pdh; p < 0.01) was significantly attenuated. The HFC + 5SS diet-fed rats exhibited elevated hepatic Cyp7a1 (p < 0.001), Hmgcr (p < 0.001) and Ldlr (p < 0.001) mRNA expression levels compared to the HFC diet-fed rats. These results suggest that SS may possess anti-adipogenic and lipid-lowering effects by enhancing lipid and cholesterol efflux in mammals.

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Section: Discussionmentioning

confidence: 99%

Stachys sieboldii Miq. Root Attenuates Weight Gain and Dyslipidemia in Rats on a High-Fat and High-Cholesterol Diet

Lee

Kim

et al. 2020

Nutrients

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“…For example, plasma lipocalin-2 is upregulated in pediatric thyroid cancer and could have applications as a new biomarker. 10 Serum lactate dehydrogenase has also been shown to act as a significant marker of head and neck squamous cell carcinoma, 11 and Epstein-Barr virus (EBV) DNAs or miRNAs are significantly correlated with distant metastasis and death in patients with NPC. [12][13][14][15][16][17][18] Serum hsa-miR-1273 g-3p might also have potential applications as both a prognostic and diagnostic biomarker of recurrent epithelial ovarian cancer.…”

mentioning

confidence: 99%

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

et al. 2019

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Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.

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“…However, the levels of serum LDH was highest in cases of moderately differentiated carcinoma as compared to poorly differentiated carcinoma. The possible reason could be that the high rate of glucose utilization (indicated by hexokinase activity) found in more poorly differentiated tumors has a higher component of aerobic oxidative metabolism (indicated by malate dehydrogenase activity) and a relatively lower contribution from anaerobic metabolism (indicated by LDH activity) than do the rates found in more differentiated tumors leading to lower LDH levels (Bhattacharjee et al, 2018). Banerjee et al, (1989) also studied the histochemical distribution of lactate, isocitrate and succinate dehydrogenases in normal oral epithelium and in well-differentiated SCC and found it to be more in the malignant cells.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Salivary and Serum Alkaline Phosphates Level and Lactate Dehydrogenase Levels in Patients with Tobacco Related Oral Lesions with Healthy Subjects - A Step Towards Early Diagnosis

Goyal¹

2020

Asian Pac J Cancer Prev

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Cancer is the second most common disease in India responsible for maximum mortality with about 0.3 millions deaths per year (Imran et al., 2012; Dhivyalakshmi and Uma Maheswari, 2014). In India the incidence of oral cancer is about 3-7 times more common as compared to resource rich countries (Dhivyalakshmi and Uma Maheswari, 2014; Misra et al., 2009). India tops in the prevalence of oral cancer in the world and remains the commonest cancer amongst the male population. Oral cancer is the third most common cancer in India after cervical and breast cancer amongst women (Khan, 2012). In India, the age standardized incidence rate of oral cancer is reported at 12.6 per 100,000 people (Khan, 2012). The increased prevalence of the oral cancer in the Indian subcontinent seems to be due to the high exposure to sunlight due to farming, smoking and other smokeless tobacco habits, alcohol, spicy food, and neglect of overall oral health. It is said that one third of all oral cancers are

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Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions

Abstract: This is the first study from this highly prevalent region of HNCA showing that serum LDH could be regarded as a biomarker for malignant and premalignant conditions of the head and neck.

Cited by 14 publications

References 23 publications

Stachys sieboldii Miq. Root Attenuates Weight Gain and Dyslipidemia in Rats on a High-Fat and High-Cholesterol Diet

Stachys sieboldii Miq. Root Attenuates Weight Gain and Dyslipidemia in Rats on a High-Fat and High-Cholesterol Diet

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

Comparison of Salivary and Serum Alkaline Phosphates Level and Lactate Dehydrogenase Levels in Patients with Tobacco Related Oral Lesions with Healthy Subjects - A Step Towards Early Diagnosis

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