Correlation of serum pepsinogen with histological atrophy following successful <i>Helicobacter pylori</i> eradication

Kawai, Takashi; Kawakami, Kohei; Kataoka, Masao; Takei, Kohtaro; Taira, Satoru; Itoi, Takao; Takagi, Yuu; Aoki, Tatsuya; Serizawa, Hiromi; Rimbara, Emiko; Noguchi, Norihisa; Sasatsu, Masanori

doi:10.1111/j.1365-2036.2006.00022.x

Cited by 7 publications

(6 citation statements)

References 29 publications

(33 reference statements)

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“…Furthermore, it has been suggested that PG II could be an even better marker for this difference than PG I [ 22 ] [ 23 ]. This was confirmed by a study by Kawai and colleagues who showed that similar PG I/II levels were found 2 months after eradication and that these levels were comparable 12 and 24 months after treatment [ 24 ]. In the follow-up test, the PG I/II ratio showed an increase.…”

Section: Discussionsupporting

confidence: 69%

A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication

et al. 2017

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BackgroundHelicobacter pylori (H. pylori) eradication is usually assessed using the 13C-urea breath test (UBT), anti-H. pylori antibody and the H. pylori stool antigen test. However, a few reports have used pepsinogen (PG), in particular, the percentage change in the PG I/II ratio. Here, we evaluated the usefulness of the percentage changes in serum PG I/II ratios for determining the success of eradication therapy for H. pylori.Materials and methodsIn total, 650 patients received eradication therapy from October 2008 to March 2013 in our Cancer Institute Hospital. We evaluated the relationship between H. pylori eradication and percentage changes in serum PG I/II ratios before and 3 months after treatment with CLEIA® (FUJIREBIO Inc, Tokyo, Japan). The gold standard of H. pylori eradication was defined as negative by the UBT performed 3 months after completion of eradication treatment. Cut-off values for percentage changes in serum PG I/II ratios were set as +40, +25 and +10% when the serum PG I/II ratio before treatment was below 3.0, above 3.0 but below 5.0 and 5.0 or above, respectively.ResultsSerum PG I and PG II levels were measured in 562 patients with H. pylori infection before and after eradication therapy. Eradication of H. pylori was achieved in 433 patients studied (77.0%). The ratios of first, second, third-line and penicillin allergy eradication treatment were 73.8% (317/429), 88.3% (99/112), 75% (12/16) and 100% (5/5), respectively. An increasing percentage in the serum levels of the PG I/II ratios after treatment compared with the values before treatment clearly distinguished success from failure of eradication (108.2±57.2 vs. 6.8±30.7, p<0.05). Using the above cut-off values, the sensitivity, specificity and validity for determination of H. pylori were 93.1, 93.8 and 93.2%, respectively.ConclusionIn conclusion, the percentage changes in serum PG I/II ratios are useful as evaluation criteria for assessing the success of eradication therapy for H. pylori.

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Section: Discussionsupporting

confidence: 69%

A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication

et al. 2017

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“…Using the percentage change in the sPG I/II ratio between pre‐eradication and post‐eradication, the authors proposed that an increase in the sPG I/II ratio is a reliable biomarker for successful H. pylori eradication. In the present study, decreased sPG I and an increased sPG I/II ratio after eradication were maintained during all follow‐up time points (≥ 36 months), with no significant differences between the H. pylori ‐eradicated and H. pylori ‐negative groups, which is consistent with the findings of previous studies …”

Section: Discussionsupporting

confidence: 93%

“…However, in European countries, the cut‐off values for sPG I and the sPG I/II ratio are ≤56 ng/mL and ≤ 5, respectively, for a fundic atrophy diagnosis . This non‐invasive serological marker has been found to be a predictor of H. pylori eradication . Osumi et al .…”

Section: Discussionmentioning

confidence: 99%

Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication

Noh

Kim

Choi

et al. 2020

J of Gastro and Hepatol

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“…The PG I/II ratio is a widely accepted indicator for gastric atrophy, and an increase in this ratio is also considered as an result of the successful H. pylori eradication. 26 Another study also reported that the percentage changes in serum PG I/II ratios revealed the high relation to the outcome of eradication therapy for H. pylori. 11 Taken together, H. pylori eradication contributes to the improvement of gastric cell secretion and the reversibility of atrophic gastritis, and the reduction ratio of H. pylori IgG antibodies might be related to the improve-ment of gastric mucosal atrophy.…”

Section: Discussionmentioning

confidence: 97%

Changes in Helicobacter pylori Immunoglobulin G Levels and Gastric Mucosal Atrophy after Successful Eradication of Helicobacter pylori

Kim

Lee

Kwon

et al. 2019

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: Limited information is available about the relationship between Helicobacter pylori (H. pylori) immunoglobulin (Ig) G and serum pepsinogen (pepsinogen [PG], a marker of gastric mucosal atrophy) concentrations after H. pylori eradication. Materials and Methods: Eligible patients who underwent endoscopic submucosal dissection (ESD) for early gastric cancer from in a tertiary-referral center, and whose serum H. pylori IgG and PG concentrations were measured at the time of performing ESD and one year post-ESD, were selected. Successful H. pylori eradication was achieved after ESD in all the patients. According to the decrease in serum H. pylori IgG concentration after bacterial eradication, the patients were categorized as group 1 (IgG concentration decreased by <50%), and group 2 (IgG concentration decreased by ≥50%). Results: Of the 106 patients, 25 (23.6%) were classified into group 1 and 81 (76.4%) into group 2. One year after H. pylori eradication, the serum PG II concentration was significantly decreased in group 2 (12.46±8.18 vs. 8.28±6.11, P=0.024). Although the serum PG I/II ratio of group 2 was higher than that of group 1 (8.32±4.52 ng/mL vs. 6.39±4.04 ng/mL), the difference was not significant (P=0.058). One year after successful eradication, elevated serum PG I/II ratio was observed in 21 patients (84%) in group 1 and in 77 patients (95.1%) in group 2 (P=0.087). The mean serum PG I/II ratio was also elevated in both groups. Serum PG II concentration was significantly decreased in group 2. Conclusions: A notable decrease in the concentration of H. pylori IgG antibody after bacterial eradication might reflect gastric mucosal atrophy. However, our study showed no statistically significant difference.

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Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication

Abstract: SUMMARYBackground Levels of pepsinogen have been reported to correlate with the degree of gastric atrophy in Helicobacter pylori-infected gastric mucosa.

Cited by 7 publications

References 29 publications

A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication

A significant increase in the pepsinogen I/II ratio is a reliable biomarker for successful Helicobacter pylori eradication

Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication

Changes in Helicobacter pylori Immunoglobulin G Levels and Gastric Mucosal Atrophy after Successful Eradication of Helicobacter pylori

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