Correlation of serum PSA and Gleason score in Nigerian men with prostate cancer

Okolo, CA; Akinosun, OM; Shittu, O B; Olapade-Olaopa, E.O.; Okeke, L.I.; Akang, E. E. U.; Ogunbiyi, J O

doi:10.1007/bf02994508

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…The mean age at diagnosis in this study was 68yrs and youngest patient was 44yrs. This is comparable with studies done by Mwakyoma HA et al, Jackson LA et al and Okolo CA et al [6], [7], [8] . In our study, there were four patients younger than 50 yrs who had prostate cancer.…”

Section: Discussionsupporting

confidence: 82%

“…84.3% of patients had high values of PSA (>10ng/ml). 5.9 % (three cases) of our patients had PSA value in normal range (< 4 ng/ml) and all the three cases had Gleason score of [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…The results of various studies on correlation between Gleason grade and pre treatment PSA levels are conflicting. Some studies have reported positive correlation between the two [6], [7], [8], [10], [19] . According to them, prostate cancer cells produce more PSA than normal cells and hence poorly differentiated cancer cells secrete and release greater amounts of PSA than the well differentiated ones [19] .…”

Section: Discussionmentioning

confidence: 99%

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Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Gurumurthy¹

2015

SJCM

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Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value < 0.05 was considered significant. Patients were aged predominantly between 60 to 70 yrs. Majority (66.7%) had poorly differentiated adenocarcinoma. 84.3% had high values of PSA (>10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant ('p' value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.

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Section: Discussionsupporting

confidence: 82%

“…84.3% of patients had high values of PSA (>10ng/ml). 5.9 % (three cases) of our patients had PSA value in normal range (< 4 ng/ml) and all the three cases had Gleason score of [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Gurumurthy¹

2015

SJCM

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“…These differences may reflect symptom-based diagnosis in Senegal compared to diagnosis following elevated PSA and/or positive digital rectal examination (DRE) in the USA. A number of papers in African populations have characterized PSA levels, use of screening, and the relationship of PSA with prostate tumor characteristics [9–13]. Similar differences between prostate cancer characteristics among men in New York, Guyana, and Trinidad have been reported with respect to tumor aggressiveness and survival [14].…”

Section: Introductionmentioning

confidence: 97%

Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

et al. 2013

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Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.

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“…14 Penelitian Okolo dkk (2008) juga menemukan kecenderungan peningkatan kadar PSA serum sebelum operasi dengan peningkatan derajat histopatologi, secara statistik menunjukkan hubungan yang positif. 20 Singh dkk menemukan kadar PSA serum sebelum operasi yang terbanyak 4,1-10 ng/ml yaitu 50 kasus (34%), diikuti dengan kadar >20 ng/ml sebanyak 46 kasus (31,1%), kadar 10,1-20 ng/ml sebanyak 41 kasus (27,7%) dan kadar <4 ng/ml sebanyak 11 kasus (7,4%). 11 Dari kepustakaan dijelaskan bahwa saat kanker prostat berkembang menyebabkan volume jaringan tumor bertambah sehingga jaringan tumor menjadi semakin tidak teratur dan skor Gleason juga ikut meningkat.…”

Section: Tabel 3 Distribusi Frekuensi Invasi Perineural Berdasarkan unclassified

Adenokarsinoma Prostat: Penilaian Prognostik Dan Derajat Histopatologi

Putriyuni¹,

Hilbertina²

2015

MKA

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AbstrakKanker prostat merupakan kanker kedua terbanyak pada pria di seluruh dunia. Tujuan penelitian ini adalah untuk mengetahui faktor prognostik adenokarsinoma prostat seperti derajat histopatologi berdasarkan the 2005 ISUP modified Gleason system, invasi perineural dan kadar PSA serum sebelum operasi. Ini adalah suatu penelitian deskriptif kasus adenokarsinoma prostat yang didiagnosis di laboratorium patologi anatomi periode 2010-2012. Data usia dan kadar PSA diperoleh dari rekam medik. Review sediaan histopatologi dilakukan untuk konfirmasi skor Gleason, lalu dikelompokan berdasarkan derajat histopatologi. Kasus adenokarsinoma prostat yang memenuhi kriteria inklusi adalah 163. Hasil penelitian menunjukkan kasus adenokarsinoma prostat terbanyak pada kelompok usia 61-70 tahun sebanyak 38,65%, derajat histopatologi poorly differentiated yaitu 46,63%, invasi perineural 22,7% dan 83,33% kadar PSA serum >20 ng/ml. Pada kelompok usia 51-60 tahun adenokarsinoma prostat terbanyak ditemukan dengan derajat histopatologi well differentiated; sedangkan kelompok usia 61-70 tahun, 71-80 tahun dan 81-90 tahun terbanyak poorly differentiated. Invasi perineural positif terbanyak pada derajat histopatologi poorly differentiated. Semua derajat histopatologi adenokarsinoma prostat menunjukkan kadar PSA serum terbanyak >20 ng/ml. Penelitian ini menunjukkan kecenderungan peningkatan usia, invasi perineural dan kasus dengan kadar PSA serum >20 ng/ml bersamaan dengan peningkatan derajat histopatologi adenokarsinoma prostat.

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Correlation of serum PSA and Gleason score in Nigerian men with prostate cancer

Cited by 23 publications

References 16 publications

Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

Adenokarsinoma Prostat: Penilaian Prognostik Dan Derajat Histopatologi

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