Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Gurumurthy, Deepika

doi:10.11648/j.sjcm.s.2015040401.11

Cited by 16 publications

(18 citation statements)

References 17 publications

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“…13 The integrity of the prostatic tissue is lost by the undergoing various pathological processes, which are responsible for the release of prostate-specific antigen (PSA) into blood circulation, and there is an increase in the serum PSA lavels. 14,15 The increase in PSA values also depends on upon the differentiation of tumor cells. 16 About 80% of histologically proven adenocarcinoma have the serum PSA level > 4ng/ml, and it is evident in 25 -30% with nodular hyperplasia, prostatitis, infarcts, prostatic massage or cystoscopy.…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of clinically diagnosed prostatic lesions.

Yousfani

Memon

Suria³

et al. 2020

TPMJ

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Objectives: To correlate the clinically diagnosed prostatic lesion with histopathological evaluation, Gleason scoring andserum prostate specific antigen (PSA) levels in a tertiary care centre. Study Design: Observational Study. Setting: The current study was conducted in multiple centers of Sindh like Department of Surgery Unit-III, Peoples University of Medical and Health Sciences, Nawabshah CMCH Larkana, Jinnah Sindh Medical University and Al-Tibri Medical College and Hospital Karachi. Period: January 2018 to December 2019. Material & Methods: on 112 consecutive cases of clinically diagnosed prostatic disease, all the relevant demographic and clinical details including digital rectal examination (DRE) findings and serum PSA levels were recorded on a proforma designed for the study. PSA values of all these cases were recorded before the surgical procedure. The tissue sample of prostate was collected after surgery and histologically analysed for the confirmation of diagnosis and the Gleason scoring was made. All the results obtained were statistically analysed and tabulated. Results: The age of patients ranged 34-81 years, with mean age of 58+3.4 years. The adenocarcinoma was detected in 05 cases, hyperplasia in 92 cases and hyperplasia with prostatitis in 07 cases. The carcinoma was clinically diagnosed in 17 cases but after histological evaluation, the carcinoma was confirmed in 03 cases and 02 cases of cancer were confirmed among clinically diagnosed cases of hyperplasia. Majority of cases of hyperplasia were having the PSA level < 4ng/ml No any case of adenocarcinoma have PSA level below 4ng/ml, and majority of the cases of denocarcinoma were having PSA level above 20ng/ml. majority of malignant lesions were having PSA level above 20ng/ml and the Gleason score above 6. No any case of malignancy was detected in those patients having PSA level below 4ng/ml. Conclusion: The histopathological evaluation with serum PSA levels is necessary in all cases of prostatic disease to rule out the possibility of malignant pathology.

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Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of clinically diagnosed prostatic lesions.

Yousfani

Memon

Suria³

et al. 2020

TPMJ

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“…20 Wadgaonkar et al and Gurumurthy et al reported findings similar to our study with significant elevation in serum PSA levels in PIN and prostate carcinoma patients. 21,16 Serum PSA levels more than 10 ng/ml is highly indicative of prostate cancer. So, patients having PSA >10 ng/ml should be considered for surgical intervention as early as possible because of high probability of prostate carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Shetty et al reported BPH in only 36.6% patients, prostatitis in 30%, PIN in 15.3% and carcinoma in 18% patients 15. Gurumurthy et al reported PIN in 5.95% cases of prostatic lesions 16. Horninger et al reported frequency of PIN in 2.91% patients and Anderson-Jackson et al in 4.07% patients, respectively.…”

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confidence: 99%

Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

Samad¹,

Fayyaz²,

Siddiqa³

et al. 2019

JIMDC

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Background: Pathological changes that mainly affect prostate gland are prostatitis, benign prostatic hyperplasia (BPH) and cancerous lesions. Digital rectal examination (DRE), Transrectal Ultrasonography (TUS), and prostate specific antigen (PSA) followed by histopathological examination, are routinely used tests for diagnosis of prostate lesions. The aim of the present study is to determine the role of serum PSA levels in differentially diagnosing the different types of prostate lesions.Material and Methods: This retrospective (observational) study was conducted in Ibn-e-Sina Hospital Multan. Data of 2189 patients who were operated from 2007 to 2017 due to prostatic lesions were included in this analysis. Patients with BPH, prostatitis, prostate carcinoma and Prostatic Intraepithelial Neoplasia (PIN) were grouped according to serum PSA levels (ranging from 0 to >100 ng/ml) into five groups. Frequencies and percentages were calculated for different histopathological findings. Association of PSA levels with different histological patterns was determined with chi-square test with P-value < 0.05 taken as significant difference.Results: Mean age of patients was 62.45+10.64 years. On histopathology, BPH was diagnosed in 1676 (76.56%) patients, prostatitis in 133 (6.07%), carcinoma in 378 (17.26%) and PIN in 02 (0.09%) patients, respectively. Serum PSA levels of 4.01-10 ng/ml were found in 1050 (62.64%) BPH patients and in 59 (44.36%) prostatitis patients. Serum PSA levels of 10.01-20 ng/ml were found in only 40 (2.4%) BPH patients, 47 (35.33%) prostatitis patients, 22 (5.82%) carcinoma patients and in 1 (50.0%) PIN patient. Serum PSA levels of 20.01-100 ng/ml were found in 32 (1.9%) BPH patients, 11 (8.27%) prostatitis patients, 302 (79.89%) carcinoma patients, and in 1 (50.0%) PIN patient. Serum PSA levels of >100 ng/ml were absent in patients with BPH and PIN, and present in 1 (0.75%) prostatitis and 54 (14.28%) carcinoma patients.Conclusion: Benign prostatic hyperplasia was the commonest lesion in our patients (76.56%) with serum PSA levels >10 ng/ml reported in all patients with prostate carcinoma and prostatic intraepithelial neoplasia (PIN) patients.

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“…[20] Our study results were in concordance with other studies which found a statistically significant assosciation between higher Gleason score and increased sPSA levels. [36][37][38]Studies across globe also showed that there is statistically significant correlation between Gleason score and proportion of cells expressing Ki67 except in one study by Munoz E et al who concluded that they didn't find significant relation between Ki67 and Gleason score which may be due to smaller sample size. [26] Our study which included 100 cases of CaP is in concordance with other studies.…”

Section: Discussionmentioning

confidence: 99%