Correlation of structure and function of the macula in patients with retinitis pigmentosa

Battu, Rajani; Khanna, Anjani; Hegde, Bharath; Berendschot, Tos T. J. M.; Grover, Sandeep; Schouten, Jan S. A. G.

doi:10.1038/eye.2015.61

Cited by 40 publications

(26 citation statements)

References 31 publications

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“…A future study should investigate the structure-function relationship in the MP-3 and the HFA 10–2, measuring retinal thickness using optical coherence tomography (OCT); in particular the thickness between the retinal pigment epithelium and the outer plexiform layer. [20] In a recent study by Hirooka et al, the measured sensitivities were compared between HFA 10–2 and MP-3 in patients with glaucoma. [21] Similarly to our result, MP-3 sensitivity was lower than that with HFA 10–2.…”

Section: Discussionmentioning

confidence: 99%

Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Igarashi¹,

Matsuura²,

Hashimoto³

et al. 2016

PLoS ONE

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PurposeThe purpose of the current study is to investigate the test-retest reproducibility of visual fields (VFs) measured with the MP-3 microperimeter, in patients with retinitis pigmentosa (RP).MethodVFs were twice measured with the MP-3 and also the Humphrey Field Analyzer, using the 10–2 test grid pattern in both perimeters, in 30 eyes (15 right and 15 left eyes) of 18 RP patients (11 males and 7 females). Test-retest reproducibility was assessed using the mean absolute deviation (MAD) measure at all 68 points in the test grid. Reproducibility was also evaluated using the intraclass correlation coefficient (ICC) of VF sensitivities.ResultThe mean sensitivity measured in the HFA 10–2 was significantly higher than that measured in the MP-3 in both the first and second VF tests (p <0.0001, linear mixed model). The MAD was 2.4±0.6 [1.1 to 3.6] dB for MP-3 and 2.4±0.9 [1.1 to 5.1] dB for HFA 10–2, which was not significantly different (p = 0.76, linear mixed model). The ICC value associated with the MP-3 VFs was 0.81±0.13 [0.49 to 0.98], which was significantly larger than that observed for the HFA 10–2 VFs: 0.77±0.19 [0.20 to 0.94] (p = 0.043, linear mixed model).ConclusionThe MP-3 microperimeter appears to be useful to evaluate central visual function in RP eyes, exhibiting test-retest reproducibility that is equal to, or better than, that observed in HFA 10–2 VFs.

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Section: Discussionmentioning

confidence: 99%

Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Igarashi¹,

Matsuura²,

Hashimoto³

et al. 2016

PLoS ONE

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“…In addition, there is a prominent transition zone (TZ) from relatively healthy central retina to more severely affected peripheral retina, which can now be directly visualized using optical coherence tomography (OCT). 1 Of particular interest is the apparent correlation between measures of visual function and the integrity of the hyperreflective photoreceptor bands seen on OCT. 2–12 Although this approach provides a general framework for assessing the structure–function relationship in RP, the limited lateral resolution of current OCT precludes direct cellular level examination of rod and cone structure. Undetectable subtle changes in photoreceptor structure may explain observed dissociations between visual function metrics and OCT findings in a number of retinal diseases.…”

mentioning

confidence: 99%

Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome

Sun

Johnson

Langlo

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeThe purpose of this study was to examine cone photoreceptor structure in retinitis pigmentosa (RP) and Usher syndrome using confocal and nonconfocal split-detector adaptive optics scanning light ophthalmoscopy (AOSLO).MethodsNineteen subjects (11 RP, 8 Usher syndrome) underwent ophthalmic and genetic testing, spectral-domain optical coherence tomography (SD-OCT), and AOSLO imaging. Split-detector images obtained in 11 subjects (7 RP, 4 Usher syndrome) were used to assess remnant cone structure in areas of altered cone reflectivity on confocal AOSLO.ResultsDespite normal interdigitation zone and ellipsoid zone appearance on OCT, foveal and parafoveal cone densities derived from confocal AOSLO images were significantly lower in Usher syndrome compared with RP. This was due in large part to an increased prevalence of non-waveguiding cones in the Usher syndrome retina. Although significantly correlated to best-corrected visual acuity and foveal sensitivity, cone density can decrease by nearly 38% before visual acuity becomes abnormal. Aberrantly waveguiding cones were noted within the transition zone of all eyes and corresponded to intact inner segment structures. These remnant cones decreased in density and increased in diameter across the transition zone and disappeared with external limiting membrane collapse.ConclusionsFoveal cone density can be decreased in RP and Usher syndrome before visible changes on OCT or a decline in visual function. Thus, AOSLO imaging may allow more sensitive monitoring of disease than current methods. However, confocal AOSLO is limited by dependence on cone waveguiding, whereas split-detector AOSLO offers unambiguous and quantifiable visualization of remnant cone inner segment structure. Confocal and split-detector thus offer complementary insights into retinal pathology.

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“…Microperimetry measurements have been reported in eyes with a clinical diagnosis of RP and average MS ranging from 5.1 to 19.3 dB. 11 , 37 – 39 However, it is difficult to directly compare these results with our study owing to the genetic heterogeneity of previous study populations and different devices and grid patterns used. Interocular symmetry is a feature in rod–cone dystrophy.…”

Section: Discussionmentioning

confidence: 81%

“…The MAIA ( Ma cular I ntegrity A ssessment; CenterVue, Padova, Italy) device is a commercially available confocal scanning laser ophthalmoscope-based microperimeter that has demonstrated robust reliability, 9 intersession agreement, 9 and coefficient of repeatability. 10 The MAIA has been widely used in routine clinical care 11 – 13 as well as in monitoring retinal function in clinical trials. 14 – 16 More recently, the MAIA device has been used to demonstrate spatial correlation between decreased retinal sensitivity and the doughnut region bound by the double hyperautofluorescent rings 17 and the perifoveal region of reduced deep capillary plexus vessel density on optical coherence tomography angiography 18 in USH2A retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy

Charng

Lamey

Thompson

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose Microperimetry is commonly used to assess retinal function. We perform cross-sectional and longitudinal analysis on microperimetry parameters in USH2A retinopathy and explore end points suitable for future clinical trials. Methods Microperimetry was performed using two grids, Grid 1 (18° diameter) and Grid 2 (6° diameter). In Grid 1, four parameters (number of nonscotomatous loci, mean sensitivity [MS], responding point sensitivity [RPS], and edge of scotoma sensitivity [ESS]) were analyzed. In Grid 2, number of nonscotomatous loci and MS were examined. Interocular symmetry was also examined. Longitudinal analysis was conducted in a subset of eyes. Results Microperimetry could be performed in 16 of 21 patients. In Grid 1 ( n = 15; average age, 35.6 years), average number of nonscotomatous loci, MS, RPS, and ESS were 46.6 loci, 10.0 dB, 14.7 and 9.6 dB, respectively. In Grid 2 ( n = 13; average age, 37.4 years), 12 eyes had measurable sensitivity across the entire grid. Average MS was 23.8 dB. Interocular analysis revealed large 95% confidence intervals for all parameters. Longitudinally, Grid 1 ( n = 12, average follow-up 2.6 years) ESS showed the fastest rate of decline (–1.84 dB/y) compared with MS (–0.34 dB/y) and RPS (–0.90 dB/y). Conclusions Our data suggest that ESS may be more useful than MS and RPS in test grids that cover a large extent of the macula. We caution the use of contralateral eye as an internal control. Translational Relevance ESS may decrease the duration or sample size of treatment trials in USH2A retinopathy.

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Correlation of structure and function of the macula in patients with retinitis pigmentosa

Cited by 40 publications

References 31 publications

Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome

Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy

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