Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels

Abstract

Our study shows that clinical activity of the disease as recorded by the "SCORAD" index can be used as an indicator of the hematological abnormalities as well as to some extent as a prognostic indicator. Family history of atopy correlates with the hematological abnormalities only if both parents are involved and bronchial asthma is the only associated atopic condition which correlates with the parameters of the disease .

Toll-like receptor 2 in patients with atopic dermatitis

“…These results are almost in agreement with the reports of many studies [26][27][28][29][30]. Also, a highly statistically significant positive correlation was found between serum IgE levels and the surface area score, which is in agreement with Wu et al [31], who reported that serum levels of total IgE correlated with the SCORAD index in pediatric patients with AD; they added that serum levels of total IgE can serve as serum markers for monitoring disease activity in childhood AD.…”

Serum measurement of interleukin‐31 (IL‐31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring

“…21 It was reported that the eosinophil counts roughly correlated with the disease severity, and that very high counts were common in severe cases of atopic dermatitis who had a personal or family history of respiratory atopy, while normal or moderately elevated counts were obtained in severe cases of 'pure' atopic dermatitis who had neither a personal nor a family history of respiratory atopy. 22,23 Thus, it was suggested that disease severity and personal or family history of respiratory atopy are important factors in determining high blood eosinophil counts in atopic dermatitis. As children recruited in our study had 'pure' atopic dermatitis without any history of other atopic disorders, the lack of correlation between the indices of atopic dermatitis severity and the absolute eosinophil count could be expected.…”

A Meta-Analysis of Randomized, Placebo-Controlled Clinical Trials of Efamol® Evening Primrose Oil in Atopic Eczema. Where Do We Go from Here in Light of More Recent Discoveries?

“…Some studies have not confirmed an association between childhood and adult atopic eczema and serum IgE levels [47,48]. While recently, IgE levels in both children and adults with atopic eczema were shown to be significantly higher than in controls [49]. In addition, its direct association with lower than normal GLA levels has implied that abnormal fatty acid metabolism is part of the atopic condition [50].…”