Correlation of the ultrasonic appearance of the ovaries in polycystic ovarian disease and the clinical, hormonal, and laparoscopic findings

Tabbakh, G. H. El; Lotfy, Ibrahim; I, Azab; Rahman, Hany Abdel; Southren, A. Louis; Aleem, Fatma A.

doi:10.1016/0002-9378(86)90478-3

Cited by 37 publications

(8 citation statements)

References 2 publications

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“…We did not find any correlation between ovarian volume and any of the hormones studied in agreement with others (Tabbakh et al 1986; Franks 1989). However, others have shown a correlation between serum testosterone (Conway et al 1989) and ovarian size although the difference in ovarian volume between patients with high and normal testosterone was small.…”

Section: Discussionsupporting

confidence: 93%

Which hormone tests for the diagnosis of polycystic ovary syndrome?

Robinson¹,

Rodin²,

Deacon

et al. 1992

BJOG

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Objective To assess the frequency of abnormal values for hormone measurements commonly used in the biochemical diagnosis of polycystic ovary syndrome (PCOS). Design Hormone measurements in 63 unselecled women with clinical and ultrasound diagnosis of PCOS attending gynaecological and general endocrine clinics in a District General Hospital were compared with those from a group of 20 normal ovula‐tory controls in the early follicular phase of their cycles. Measurements Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratio, total testosterone, derived free testosterone, sex hormone binding globulin, androstenedione, and dehydroepiandrosterone (DHEA) were measured by radioimmunoassays. LH and FSH measured by two different assays. Results The mean serum LH and LH/FSH ratio were significantly (P<0.01) higher in the women with PCOS compared with the normal group, but these two measurements were in the abnormal range for only 35% and 41–44%, respectively. Absolute gonadotrophin values were significantly different using the two assay methods, which employed the same reference preparation as standard. Mean serum total testosterone concentration was significantly higher in the PCOS group and was the most frequently (70%) abnormal biochemical marker for PCOS. Sex hormone binding globulin (SHBG) did not differ significantly between the two groups but showed a negative correlation with body mass index in women with PCOS. The combination of SHBG and testosterone to derive a free testosterone value did not further aid the biochemical diagnosis of PCOS. Androstenedione was significantly higher in the PCOS group than in the control group, with a frequency of 53%. There was no significant difference in DHEA‐S between the two groups. Conclusion When typical ovarian ultrasound appearances plus the clinical features of oligomenorrhoea and/or hirsuitism were used to define PCOS total testosterone was the best single hormonal marker of the condition. Testosterone, androstenedione or LH, either alone or in combination, were raised in 86% of women with PCOS and these should be the definitive hormonal tests. Using LH/FSH ratio as a biochemical criterion for diagnosis of PCOS should be abandoned because of its low sensitivity. To be of value the normal range for all hormones should be precisely defined in a group of regularly ovulating women in the early follicular phase of the cycle for the assay used in each laboratory.

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Section: Discussionsupporting

confidence: 93%

Which hormone tests for the diagnosis of polycystic ovary syndrome?

Robinson¹,

Rodin²,

Deacon

et al. 1992

BJOG

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show abstract

“…More relevant to the interpretation of our data, a number of reports in the literature have noted the association between some ultrasound ovarian characteristics and the androgenic milieu (33,(36)(37)(38). In accordance with the this evidence, the concomitancy between the modifications in the ovarian volume and, in particular, S/A ratio and the changes in androgens levels found in 10 out of the 13 metformin-treated PCOS subjects seems to further underscore the link between the androgenic assessment and such ovarian features.…”

Section: Tablesupporting

confidence: 89%

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial

Romualdi

Giuliani

Cristello

et al. 2010

Fertility and Sterility

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“…followed by high LH (65,8%). high FT (59,2%) and 17-OH progesterone (48,7%), Our current study shows LH/FSH ratio to be the commonest abnormality in the group with positive ultrasound (91,7%) which is much higher than reported by other studies [21,22], The percentage of patients who qualified for the diagnosis of PCOS varies significantly with the number of criteria used ranging from 59%, when only ultrasound findings are used, to as low as 3.8% when more than one criteria was used, e,g,, positive ultrasound, with irregular periods and infertility, high LH/FSH ratio, obesity and high T,…”

Section: Discussioncontrasting

confidence: 59%

“…There is no consensus in the medical literature on the definition of PCOS and this no doubt accounts for the widely variable presentation of affected individuals [14-20], Many hormonal abnormalities can occur in PCOS including elevated LH/FSH ratio, LH, PRL, FT, DHEAS, A. 17-OHP and decreased P, In one of the few studies reporting correlation of ultrasound appearances of ovaries to the presence of PCOS, as defined by clinical, hormonal and laparoscopic findings [21], ultrasound examination evidenced that 75% presented large polycystic ovaries. In a different study [22| elevated LH/FSH ratio was the abnormality most commonly found (68,4%).…”

Section: Discussionmentioning

confidence: 99%

Women with clinically significant hirsutism always have detectable endocrinological abnormalities

Al-Khawajah

Neel

1997

Acad Dermatol Venereol

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study a consecutive series of 120 hirsute Saudi women were thoroughly investigated for possible causes of their Aim In hirsutism.Methods In addition to a detailed clinical evaluation the foiiowing hormones were measured: testosterone, free testosterone, dehydroepiandrosterone sulphate, prolactin, progesterone, luteinising hormone. fo[llcle stimulating hormone, thyroid stimulating hormone, T*. T4. cortiso[, 17-hydroxyprogesterone. androstenedione atid dihydrotestosterone.Results All evaluable patients had at least one hormonal abnormality and 85.9% had at least one of the five major androgens elevated. Polycystic ovaries were found iti $9% of the patients, hyperprolaetinaemia in 34.69^^, and 14.1'^ had congenital adrenal hyperplasia.Conclusion We recommend a two-step laboratory work-up that will unravel a cause fur hirsutism in most if not all hirsute women. © 1997 Elsevier Science B.V.

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Correlation of the ultrasonic appearance of the ovaries in polycystic ovarian disease and the clinical, hormonal, and laparoscopic findings

Cited by 37 publications

References 2 publications

Which hormone tests for the diagnosis of polycystic ovary syndrome?

Which hormone tests for the diagnosis of polycystic ovary syndrome?

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial

Women with clinically significant hirsutism always have detectable endocrinological abnormalities

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