Correlation of Tissue Transglutaminase with Modified Marsh Grading in Celiac Disease: A Prospective Cohort Study

Jora, Rakesh; Raghuvanshi, Vikrant; Payal, Vikas; Sharma, Pawan; Vishnoi, S K

doi:10.1007/s12098-017-2323-3

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…Anti - tTG rendered a 90% positive predictive value, which was correlated with the antibody titer with higher titers correlating with higher predictive values (15, 18). In addition, Elitsur et al, noted that anti - tTG antibody titer is three times higher than upper limits is not a good representative of CD in children (19).…”

Section: Resultsmentioning

confidence: 93%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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ContextCeliac disease (CD) is a common phenomenon in children with Type 1 diabetes (T1D). In the present review, we have discussed the pathogenesis, diagnostic biomarkers, risk factors, and prognosis of CD in the context of pediatric T1D.Evidence AcquisitionLiterature published in Web of Science, PubMed, Scopus, Google Scholar, and Cochrane Library were scrutinized up to the end of 2017. The keywords of celiac disease, Type 1 diabetes, children, and pediatric were used in different combinations.ResultsImmune cytotoxic reactions along with dampen immune regulatory functions contribute to CD in the context of pediatric T1D. Many children with simultaneous CD and T1D do not represent with the clinical signs of the enteropathy rendering a diagnostic challenge. The most common screening tests in these children are routine serological tests of CD, anti - endomysial, anti - transglutaminase, and anti - deamidated gliadin peptide antibodies. Typing for human leukocyte antigens of DQ - 2 and DQ - 8 may assist in the diagnosis of silent CD in children with T1D. The most significant shared non - HLA genetic loci of CD and T1D comprise CTLA - 4, TAGAP, IL - 18RAP, PTPN2, RGS1, SH2B3, CCR5. Interactions between these loci can be important in susceptibility to CD in T1D. Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D.ConclusionsOverall, active seropositive CD seems to be of clinical importance in T1D with significant impacts on the quality of life and predisposition to diabetes associated complications. It is important to detect CD in the context of T1D to prevent potential risks contributing to morbidities and mortalities associated with either CD or T1D.

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Section: Resultsmentioning

confidence: 93%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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“…Jora et al also performed similar type of study on marsh grading of duodenal histopathology in Celiac disease (CD) Waheed N et al from Lahore, Pakistan concluded in his study that celiac disease is not a rare disease in Asia, but an under diagnosed entity. 12,13 He conducted a descriptive cross-sectional study among 126 patients presenting in emergency room (ER) with profuse diarrhoea leading to severe dehydration, neuromuscular weakness, metabolic acidosis and electrolyte abnormalities. All patients met the standard diagnostic criteria for celiac disease including: modified Marsh…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical profile of celiac disease among malnourished children in South Rajasthan, India

Sharma

Mandot

2018

Int J Contemp Pediatr

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Background: Celiac disease (CD) is the most common genetically related food intolerance, worldwide. The objective of this study was to study the prevalence and clinical profile of malnourished children. Methods: It was a prospective and observational study. The present study was conducted in the Department of Paediatrics, Geetanjali Medical College and Hospital, Udaipur, Rajasthan. Two hundred and one children were studied. All malnourished children were initially selected and those fulfilling inclusion criteria were included in the study. A detailed interview of all the children/parents was conducted regarding symptoms commonly associated with celiac disease. All cases found positive for t-TGA (>10au/ml) were subjected to upper GI Endoscopy. Subjects were labelled as celiac disease if tissue trans-glutaminase IgA antibodies were >10 au/ml and histopathology was suggestive. Statistical analysis was done by one way ANOVA test and Chi-square as per requirements also Fisher exact and Man Whitney were applied. Results: Celiac disease was present in 23.9% of malnourished patients. Most common presenting symptoms were diarrhoea (40.2%), abdominal distension (39.9%) and abdominal pain (36.8%) and most common clinical sign was pallor, which was present in more than three-fourth of the patients (85.9%) followed by multivitamin deficiency (25.4%). Conclusions: There is a high prevalence of Celiac disease in malnourished children. Screening for Celiac disease (especially in presence of diarrhoea and abdominal distension, pain abdomen) should be an essential part of work-up in all malnourished children.

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“…Similar results were obtained in a study conducted by Jora R et al and found similar study to the present study. They conducted study among 52 children of age 2-18 years and found that most common clinical symptom among children was diarrhea followed by abdominal distention, pain in abdomen, anorexia, constipation, , edema, vitamin deficiencies, clubbing and mouth ulcers (12).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Clinical Profile of Celiac Disease Among Children at Tertiary Care Hospital

Bijarnia¹,

Dev²,

Gupta

2019

IJMBS

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Background: Celiac disease is reported to be the most common genetic and food related intolerance, globally. Celiac disease is an autoimmune disease that reported among genetically susceptible individuals. The autoimmune process is reported to be triggered by a well-identified associated environmental factor known as gluten and its related prolamins which are present in wheat, barley and rye. Material & Methods: The present prospective study was conducted at department of pediatrics of our tertiary care hospital. The study was an observational study on 30 self-reported patients during a period of one year from January 2017 to December 2017. Patients without any exclusion criteria of sex, religion and socioeconomic status were enrolled by simple random sampling. Results: In the present study, on the basis of clinical symptoms we found that in the age group of less than 5 years 75% had diarrhea, 87.5% had abdominal distension, 87.5% had abdominal pain, 75% had anorexia. In the age group of 5-10 years 50% had diarrhea, 66.6% had abdominal distension, 58.3% had abdominal pain, 66.6% had anorexia and 16.6% had constipation. In the age group of more than 10 years 70% had diarrhea, 60% had abdominal distension, 50% had abdominal pain, 40% had anorexia and 20% had constipation. Conclusion: We concluded from the present study that most common clinical symptom among children was diarrhea followed by abdominal distention, pain in abdomen, anorexia, constipation, pallor,edema, vitamin deficiencies and mouth ulcers. Keywords: Celiac disease, IgA-anti tissue transglutaminase antibodies, Screening.

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Correlation of Tissue Transglutaminase with Modified Marsh Grading in Celiac Disease: A Prospective Cohort Study

Abstract: Serum tTGA levels can be used to predict villous atrophy and biopsy may be avoided in strongly suspected cases with more than 9 times of cut-offs.

Cited by 4 publications

References 26 publications

An Overview of Celiac Disease in Childhood Type 1 Diabetes

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Prevalence and clinical profile of celiac disease among malnourished children in South Rajasthan, India

Assessment of Clinical Profile of Celiac Disease Among Children at Tertiary Care Hospital

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