Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk

Strohsnitter, William C.; Savarese, Todd M.; Low, Hoi Pang; Chelmow, David; Λάγιου, Παγώνα; Lambe, Mats; Edmiston, Kathryn; Liu, Qin; Baik, Inkyung; Noller, Kenneth L.; Adami, Hans‐Olov; Trichopoulos, Dimitrios; Hsieh, Chung‐Cheng

doi:10.1038/sj.bjc.6604183

Cited by 40 publications

(38 citation statements)

References 28 publications

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“…Birth size is known to influence breast cancer risk (Michels and Xue, 2006;Park et al, 2008), and there is compelling evidence that periadolescent growth (Ahlgren et al, 2004) and adult height (Tretli 1989;World Cancer Research Fund/American Institute for Cancer Research, 2007) are also associated with this risk. Using haematopoietic stem cells as probable correlates of the difficult-to-measure mammary stem cells, the size of their pool was positively associated with both umbilical cord growth hormones and birth weight (Savarese et al, 2007;Strohsnitter et al, 2008). No earlier investigation, however, has examined postnatal growth in relation to breast cancer risk, even though postnatal growth is rapid and the mammary gland is far from being fully differentiated (Russo and Russo, 1987).…”

Section: Discussionmentioning

confidence: 99%

Neonatal growth and breast cancer risk in adulthood

Λάγιου

Trichopoulos

et al. 2008

Br J Cancer

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Birth size of a woman has been positively associated with her breast cancer risk, particularly before menopause, but no study has investigated neonatal growth in relation to this risk. We conducted a case -control study nested within a population-based cohort of women, born in Sweden between 1901 and 1961, covering all 405 breast cancer patients and 1081 age-and hospital-matched controls, who were born after newborn charts became available. Compared to neonates who lost o200 g after birth and grew at a rate o25 g day À1 after reaching postnatal weight nadir (ie, the minimum, before starting to regain weight), those who either lost X200 g after birth or grew X25 g day À1 after nadir, or both, were at an approximately 50% increased breast cancer risk. The excess risk was striking and statistically significant among women below 50 years of age, but was not evident among older women. Immediate postnatal weight loss (an indicator of water loss, likely to reflect water retention associated with pregnancy hormones) as well as neonatal weight gain rate after the nadir (known to reflect growth hormone levels) was significantly positively associated with premenopausal breast cancer risk.

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Section: Discussionmentioning

confidence: 99%

Neonatal growth and breast cancer risk in adulthood

Λάγιου

Trichopoulos

et al. 2008

Br J Cancer

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“…Birth weight has been positively correlated with cancer risk [77]. Maternal diet composition has a significant impact on birth weight, as the following lines will prove.…”

Section: Insulin Action During Pregnancy: Early Onset Of Ir and Cancementioning

confidence: 78%

“…Birth weight has been positively correlated with subsequent risk of childhood cancer as well as several cancer types in adults [77]. According to a "stem cell burden theory" [96], the in utero environment and perinatal factors may influence the size of the overall stem cell pool as well as birth-weight.…”

Section: Birth Weight and Stem Cells-a Link To (Childhood) Cancer?mentioning

confidence: 99%

Significant Dietary Changes during Human Evolution and the Development of Cancer: From Cells in Trouble to Cells Causing Trouble

Köpp¹

2017

J Carcinog Mutagen

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In all western societies, mortality rates from cancer are high and even increasing. In striking contrast, cancer rates are very rare and even non-existent in primitive cultures, like hunter-gatherer (HG) populations. HGs are free of disease as long as they adhere to their traditional low-insulinemic "Paleolithic" nutrition. With acculturation and transition to current high-carbohydrate/high-insulinemic "Western" diets (HCHIDs), cancer develops in high rates. This paper follows the question of how significant nutritional changes, brought about by the Agricultural revolution, may cause development of cancer. The evidence presented shows that the switch from a Paleolithic to a Western nutrition has brought about significant metabolic perturbations, like an abnormally increased activation of the insulinlike growth factor system, the sympathetic nervous system and the renin-angiotensin-system, an increased expression of HIF-1α and other more, all of which are deeply involved in cancer development through promotion of proliferation, angiogenesis, inflammation, macrophage infiltration, metastasis and inhibition of apoptosis.In addition, HCHIDs generate oxidative stress which may cause mitochondrial damage and genomic instability, and may interfere with normal stem cell development. Faulty redox signaling is suggested to play a significant role in cancer development: hydrogen peroxide, generated at low concentrations, represents an important chemical mediator in the regulation of various cellular signal transduction processes, including stem cell development. Oxidative stress may be sensed by cells as redox signaling. Faulty "redox signaling" is proposed to affect normal stem cell development by sustained activation of uncoupling protein 2, leading to inhibition of differentiation ("maturation arrest"), sustained uncontrolled proliferation, and glycolysis with high expression of hexokinase II, typical features of cancer. In summary, an abnormal diet-related activation of various metabolic systems, together with faulty redox signaling, is suggested to play a pivotal role in cancer development.

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“…Cord blood IGF-1 has been shown to be positively associated with the size of the stem cell pool (Baik et al, 2005;Savarese et al, 2007), which has also been linked to birth size (Strohsnitter et al, 2008). The stem cell pool has been postulated to be related to breast cancer risk in later life .…”

Section: Discussionmentioning

confidence: 99%

“…Because such stem cells are difficult to isolate, haematopoietic stem and progenitor cells have been used as markers. Concentration of these cells in cord blood is strongly positively associated with both cord blood levels of insulin-like growth factor 1 (IGF-1) (Savarese et al, 2007) and birth weight (Strohsnitter et al, 2008), suggesting that IGF-1 may be an important factor in the intrauterine origin of breast cancer.…”

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confidence: 99%

Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

et al. 2009

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Breast cancer incidence and birth weight are higher among Caucasian than Asian women, and birth size has been positively associated with breast cancer risk. Pregnancy hormone levels, however, have been generally lower in Caucasian than Asian women. We studied components of the insulin-like growth factor (IGF) system in cord blood from 92 singleton babies born in Boston, USA, and 110 born in Shanghai, China, in 1994-1995. Cord blood IGF-1 was significantly higher among Caucasian compared with Chinese babies (Po10 À6 ). The opposite was noted for IGF-2 (PB10 À4 ). IGF-1 was significantly positively associated with birth weight and birth length in Boston, but not Shanghai. In contrast, stronger positive, though statistically non-significant, associations of IGF-2 with birth size were only evident in Shanghai. The associations of birth weight and birth length were positive and significant in taller women (for IGF-1 in Boston PB0.003 and 0.03, respectively; for IGF-2 in Shanghai PB0.05 and B0.04, respectively), among whom maternal anthropometry does not exercise strong constraints in foetal growth. The documentation of higher cord blood levels of IGF-1, a principal growth hormone that does not cross the placenta, among Caucasian than in Asian newborns is concordant with breast cancer incidence in these populations.

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Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk

Cited by 40 publications

References 28 publications

Neonatal growth and breast cancer risk in adulthood

Neonatal growth and breast cancer risk in adulthood

Significant Dietary Changes during Human Evolution and the Development of Cancer: From Cells in Trouble to Cells Causing Trouble

Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

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