Correlation of viral RNA, alanine aminotransferase, and histopathology in hepatitis C virus-associated hepatitis

Choi, Young Hwan; Putti, Thomas Choudary; Win, Khin Maung; Hu, Yuan; Remy, Prospere; Bloom, Alan S.

doi:10.1016/s1084-8592(99)80029-0

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…The ability of the tests that are currently used in the diagnosis and follow-up of CHC patients (ALT and HCV-RNA quantity) to show histological changes are equivocal, and the current guidelines generally take into account studies indicating their poor utility in follow up. Like many other studies and guidelines, findings from our study confirm the notion that ALT, HCV-RNA and GGT are not good indicators of liver inflammation as assessed by Knodell scoring (8,(22)(23)(24)(25)(26). The aim of using these follow-up markers is to determine disease activity and initiate, modify or withhold treatment accordingly.…”

Section: Discussionsupporting

confidence: 84%

Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Bugdaci¹,

Karaca²,

Alkım³

et al. 2012

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 84%

Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Bugdaci¹,

Karaca²,

Alkım³

et al. 2012

Turk J Gastroenterol

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“…These results suggest an association between the frequency of intrahepatic memory T cells at an early differentiation stage (CD28 + ) and the severity of liver inflammatio [11][12][13]. No significan correlation was detected between frequencies of these markers and serum ALT levels, which is consistent with the poor correlation between serum ALT level and liver inflammatio grade in chronic hepatitis C [14]. Of note, our data suggest different patterns of association between CD45RO, CD27, and CD28 and liver inflammation even though all 3 of these markers are thought to be related to T cell differentiation.…”

Section: Discussionsupporting

confidence: 52%

Phenotypic and Functional Status of Intrahepatic T Cells in Chronic Hepatitis C

et al. 2006

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Polychromatic flow-cytometric assays were used to analyze paired intrahepatic and peripheral lymphocyte samples from 37 patients with chronic hepatitis C. Compared with peripheral cells, intrahepatic T cells were selectively enriched with CD45RO+ memory T cells but had a lower percentage of CD4+ T cells expressing the differentiation markers CD27 and CD28. The percentage of intrahepatic CD45RO+ and CD28+ T cells correlated with the degree of liver inflammation, which suggests that memory T cells at relatively early stages of differentiation are directly involved in liver inflammation. Despite their memory phenotype, intrahepatic T cells were defective in proliferation capability, produced less interferon- gamma in response to stimulation by T cell receptor, and contained less perforin but expressed higher levels of Fas and Fas ligand, compared with their counterparts in peripheral blood. The distinct characteristics of intrahepatic T cells suggest that they play an important role in the immunopathogenesis of chronic hepatitis C.

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“…However, accumulating data indicate that ALT is not always correlated with liver cell damage, disease progression, or the response of HCV to therapy [14]. Moreover, many HCV RNA positive subjects with normal aminotransferases levels have significant liver damage despite normal liver biochemistry [15].…”

Section: Discussionmentioning

confidence: 99%

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Abdel-Moneim

Sliem

2011

Gastroenterol Res

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BackgroundAlpha-Glutathione S-transferase (α-GST) is a liver enzyme which showed properties making it useful in assessment of liver cell damage. A number of studies demonstrated its early elevation in different hepatic insults, but its pattern in HCV was controversial. Consequently, we planned this work to study the significance of Serum Alpha-Glutathione S-Transferase (α-GST) assessment in hepatitis C patients with different alanine aminotransferase (ALT) patterns.MethodsSixty-five untreated male patients with history of hepatitis C virus (HCV) positive antibodies and 21 healthy age- and sex-matched control subjects were enrolled in this study. Sera were collected for confirmation of the presence of HCV antibodies (by ELISA) as well as for assessment of the levels of α-GST, ALT, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl-transferase, total proteins, albumin and HCV RNA. HCV RNA was detected by the reverse transcription polymerase chain reaction (RT-PCR). Based on ALT level, patients were divided into three groups. Twelve patients with normal ALT levels (NALT), 29 with near normal ALT levels (NNALT), and 24 with high ALT levels (HALT). All data were statistically analyzed for significance and correlation as well as sensitivity, specificity, positive and negative predictive values.ResultsThe mean value of α-GST in HCV patients was significantly higher compared to the control with 82% sensitivity, 85% specificity, 98% positive predictive value and 63% negative predictive value. These results were more or less similar to the results of ALT and higher than the results of all the other assayed liver function tests. The sensitivity, and positive and negative predictive values of α-GST were lower than aminotransferases, but higher than the other assayed liver function tests in NNALT and HALT groups. Nevertheless, in NALT, these parameters were higher for α-GST than all the other assayed liver function tests including aminotransferases.ConclusionsAssay of α-GST has an adjuvant in evaluation of liver cell damage in HCV patients. However, its role is much more valuable in patients with normal aminotransferases for early detection of liver cell damage.

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Correlation of viral RNA, alanine aminotransferase, and histopathology in hepatitis C virus-associated hepatitis

Cited by 11 publications

References 20 publications

Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Serum complement C4 in chronic hepatitis C: Correlation with histopathologic findings and disease activity

Phenotypic and Functional Status of Intrahepatic T Cells in Chronic Hepatitis C

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

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