Correlation of visfatin levels and lipoprotein lipid profiles in women with polycystic ovary syndrome undergoing ovarian stimulation

Abstract

The aim of this study was to determine serum and follicular fluid (FF) visfatin levels in age and weight-matched women with polycystic ovary syndrome (PCOS) and normally ovulating subjects undergoing controlled ovarian stimulation and correlate them with their lipid and lipoprotein levels. We included 80 PCOS women (40 lean and 40 overweight) and 80 age- and weight-matched controls, enrolled in the IVF program. In PCOS women, we determined significantly increased serum and FF visfatin as well as serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoprotein B, lipoprotein(a) and homocysteine, while high-density lipoprotein cholesterol and apolipoprotein A1 were significantly lower compared to controls. Serum visfatin levels positively correlated with total cholesterol, LDL cholesterol, triglycerides, lipoprotein(a) and homocysteine levels and negatively with apolipoprotein A1. FF visfatin levels positively correlated with triglycerides and homocysteine and negatively with apolipoprotein A1. Dyslipidemia is common in reproductive age women with PCOS exposing them to risk for cardiovascular diseases. However, the detailed role of visfatin on lipoprotein lipid profile awaits further clarification through future investigation.

Serum visfatin levels in non-obese women with polycystic ovary syndrome and matched controls

“…Since its discovery, some association has been established between visfatin and PCOS but with conflicting results [ 4 17 18 19 20 21 22 23 24 25 26 27 28 ]. A number of studies have reported that women with PCOS have higher visfatin levels than those in BMI-matched [ 17 21 34 35 ] or unmatched controls [ 18 36 37 38 ]. Moreover, visfatin levels in normal-weight PCOS patients has been found to be higher than those in obese controls [ 19 ].…”

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

“…The study by D _ Ikmen et al [23] was treated as multiple separate studies in our meta-analysis due to different BMI and age strategies, as were the studies of Tsouma et al [36], Farshchian et al [8] and Olszanecka-Glinianowicz et al [27]. Therefore, there were 22 studies included in this metaanalysis.…”

Serum Asprosin Level in Different Subtypes of Polycystic Ovary Syndrome: A Cross-sectional Study

“…One possibility is that the serum asprosin might be influenced by confounding effects through sex hormones, specific population conditions, and repeated freeze-thaw cycles. Another possibility is the multiple interactions with some other adipokines such as irusin, visfatin, and adiponectin, which are also secreted by the white adipose tissue (WAT) and associated with PCOS [25][26][27]. Meanwhile, we found that asprosin was positively correlated with PRL.…”