Correlation of visual-evoked hemodynamic responses and potentials in human brain

Näsi, Tiina; Kotilahti, Kalle; Noponen, Tommi; Nissilä, Ilkka; Lipiäinen, Lauri; Meriläinen, Pekka

doi:10.1007/s00221-010-2159-9

Cited by 24 publications

(21 citation statements)

References 38 publications

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“…The fNIRS values retained for statistical analysis were changes in the averaged O 2 Hb and HHb computed over the 10 task blocks using the integral between 5 to 25 seconds out of the 30 seconds of the task. This integral analytic approach allows quantifying the concentration changes over time while being sensitive to task-related changes on O 2 Hb and HHb regardless of the shape of the hemodynamic response profile (Näsi et al, 2010;Safi et al, 2012). An index of hemoglobin differential (Hb diff = O 2 Hb -HHb) was also used to evaluate the level of cortical activation (Lu et al, 2015).…”

Section: Data Processingmentioning

confidence: 99%

Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

et al. 2019

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Cortical oxygenation and transcranial stimulation Highlights  Functional near infrared spectroscopy probed the sensorimotor cortex activity when using online, offline and sham high definition anodal tDCS.  Online and offline high definition anodal tDCS induced greater cortical activation 30 min after stimulation.  Concurrent application of high definition anodal tDCS during a motor task induced more pronounced changes in sensorimotor cortex activation

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Section: Data Processingmentioning

confidence: 99%

Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

et al. 2019

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“…Since this discovery of the NIRS window (700–1300 nm) into the body, it has been widely used for measurement of tissue oxygenation. Part of those studies aimed to investigate various types of brain activation [2] due to stimuli as visual [3, 4], auditory [5, 6], motor [7–9] and more recently various cognitive [10–14] ones. Other fields of application include studies of blood perfusion in muscles [15–18] and in breast cancer [19,20].…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation of NIRS spatial sensitivity

Patil

Safaie

Moghaddam

et al. 2011

Biomed. Opt. Express

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Near infrared spectroscopy (NIRS) is regarded as a potential medical diagnostic technique for investigation of hemodynamic changes. However, uncertainties pertaining to the origin of NIRS signals have hampered its clinical interpretation. The uncertainities in NIRS measurements especially in case of living tissues are due to lack of rigorous combined theoretical-experimental studies resulting in clear understanding of the origin of NIRS signals. For their reliable interpretation it is important to understand the relationship between spatial changes in optical properties and corresponding changes in the NIRS signal. We investigated spatial sensitivity of near infrared optical measurements using an experimental approach. It uses a liquid optical phantom as tissue equivalent, which is explored under robot-control by a small, approximately point like perturbation of desired optical properties, and a NIRS instrument for trans-illumination/reflection measurements. The experimentally obtained sensitivity has been analyzed and compared with numerical simulations. In preliminary experiments we investigated the influence of various optical properties of the medium and of source/detector distances on the spatial sensitivity distribution. The acquired sensitivity maps can be used to define characteristic parameters. As an example, we used a 25% threshold to define a penetration depth measure which provides values in good accordance with published ones. To the best of our knowledge this is the first experimental study of NIRS spatial sensitivity. The presented method will allow in depth experimental investigation of the influence of various conditions pertaining to medium such as optical properties of tissue (scattering and absorption) and of the source/detector configuration. 1977-1981 (1996). Zakynthinos, and I. Vogiatzis, "Near-infrared spectroscopy and indocyanine green derived blood flow index for non-invasive measurement of muscle perfusion during exercise," J. Appl. Physiol. 108(4), 962-967 (2010). 19. M. Xia, V. Kodibagkar, H. Liu, and R. P. Mason, "Tumour oxygen dynamics measured simultaneously by nearinfrared spectroscopy and 19f magnetic resonance imaging in rats," Phys. Med. Biol. 51, 45-60 (2006). 20. S. Nioka and B. Chance, "Nir spectroscopic detection of breast cancer," Technol. Cancer Res. Treat. 4, 497-512 (2005). 21. M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging," Phys. Med. Biol. 40, 955-961 (1995). 22. M. Firbank, E. Okada, and D. T. Delpy, "Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy," Phys.

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“…[61][62][63][64][65] Some others also have tried to correlate the ''fast'' signal or the Event-related optical signal 66 to VEPs. A study by Obrig et al showed coupling between fNIRS and VEP measures in response to a reversing checkerboard stimulus.…”

Section: Correlation Between Veps and Hbo Concentrationmentioning

confidence: 99%

Neural and Vascular Responses to Fused Binocular Stimuli: A VEP and fNIRS Study

Wijeakumar

Shahani

McCulloch

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The aim of our study was to investigate the correlation between neural and hemodynamic responses to stereoscopic stimuli recorded over visual cortex. METHODS.Test stimuli consisted of a static checkerboard (checks) and dichoptic static random dot (RD) presentations with no binocular disparity (ZD) or with horizontal disparity (HD). Hemodynamic responses were recorded from right and left occipital sites using functional near-infrared spectroscopy (fNIRS). Visual evoked potentials (VEPs) were recorded over three occipital sites to the onset of the same stimuli.RESULTS. Early components, N1 and P2, were sensitive to HD, suggesting that an enhanced N1-reduced P2 complex could be an indicator of binocular disparity and stereopsis. VEPs to checks and ZD stimulation were similar. fNIRS recordings showed changes in hemodynamic activation from baseline levels in response to all stimuli. In general, HD elicited a larger vascular response than ZD. Oxyhemoglobin concentration (HbO) was correlated with the VEP amplitude during the checks and HD presentations. CONCLUSIONS.We report an association between neural and hemodynamic activation in response to checks and HD. In addition, the results suggested that N1-P2 complex in the VEP could be a neural marker for stereopsis and fNIRS demonstrated differences in HbO. Specifically, checks and HD elicited larger hemodynamic responses than random dot patterns without binocular disparity. (Invest Ophthalmol Vis Sci. 2012;53:5881-5889) DOI:10.1167/iovs.12-10399 D epth perception is based on the amalgamation of monocular cues, such as lighting, accommodation, shading, blur, perspective, and motion parallax, and binocular cues, such as convergence and stereopsis. Of these, stereopsis is the principal measure of binocular vision. Multiple studies have used electrophysiologic and psychophysical methods to investigate stereoscopic processing.1-4 Aspects, such as visual persistence, hemispheric dominancy, position within the visual field, temporal frequency, and depth reversal rates, affected depth perception. 5-9 Visual evoked potential (VEP) studies have implicated the N1 (or an early negative wave) and P3 components to be elicited in the visual cortex by stereo and depth-inducing stimuli. [10][11][12][13][14][15] In accordance with these results, functional magnetic resonance imaging (fMRI) has shown definitively that areas involved in stereoscopic processing extend from the dorsal occipital [16][17][18] through to the posterior parietal areas. 16,[19][20][21] The relatively new technique of functional near-infrared spectroscopy (fNIRS) can measure changes in blood flow in response to neural activation as absolute or relative concentrations of oxyhemoglobin (HbO) and deoxyhemoglobin (Hb) levels. fNIRS relies on the principle that amplitude modulated light of two different wavelengths from the near-infrared and visible spectrum will penetrate the scalp and skull through to brain tissue. fNIRS also can be used easily in conjunction with VEPs. In previous studies, we have shown, usi...

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Correlation of visual-evoked hemodynamic responses and potentials in human brain

Cited by 24 publications

References 38 publications

Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation

Experimental investigation of NIRS spatial sensitivity

Neural and Vascular Responses to Fused Binocular Stimuli: A VEP and fNIRS Study

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