Correlations between Antepartum Maternal Metabolism and Intelligence of Offspring

Rizzo, T.; Metzger, Boyd E.; Burns, William J.; Burns, Kayreen A.

doi:10.1056/nejm199109263251303

Cited by 662 publications

(221 citation statements)

References 15 publications

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“…This paper finds that the strongest (and statistically significant) effects on math test scores are in the first trimester, when siblings fixed effects are used. This is also consistent with the findings of Rizzo et al (1991), who ascribe low blood glucose levels as a mechanism through which cognitive functioning is impaired in the first trimester. The effects on Raven's CPM, though statistically insignificant for all trimesters, are strongest for the third, followed by the first, trimester.…”

Section: A Interpreting Effects By Trimester For Salient Outcomessupporting

confidence: 80%

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The persistent effects of in utero nutrition shocks over the life cycle: Evidence from Ramadan fasting

Majid

2015

Journal of Development Economics

105

101

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Section: A Interpreting Effects By Trimester For Salient Outcomessupporting

confidence: 80%

“…Both studies emphasized the necessity for pregnant women to eat during the daytime. Thereafter, several studies have shown that accelerated starvation caused by fasting during pregnancy is correlated with the malfunctioning of certain cognitive functions (Rizzo et al, 1991).…”

Section: Evidence On First Stage Effectsmentioning

confidence: 99%

The persistent effects of in utero nutrition shocks over the life cycle: Evidence from Ramadan fasting

Majid

2015

Journal of Development Economics

105

101

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“…Esses resultados sugerem que doenças que levam à macrosomia fetal, como a diabetes gestacional 42,43 , poderiam influenciar o desenvolvimento de problemas de saúde mental em etapas posteriores. Alguns estudos têm evidenciado associação entre diabetes gestacional e transtornos de comportamento, menor capacidade cognitiva e maior hospitalização por transtornos no neuro-desenvolvimento em crianças de mulheres com esta doença 44,45 .…”

Section: Discussionunclassified

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

et al. 2011

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O objetivo foi avaliar a associação entre tamanho ao nascer e problemas de saúde mental aos 11 anos na Coorte de Nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 1993. Foram pesados e medidos ao nascer 4.358 recém-nascidos. Avaliou-se problemas de saúde mental com o questionário de capacidades e dificuldades (Strengths and Difficulties Questionnaire - SDQ). A prevalência de problemas de saúde mental foi de 32% (IC95%: 31-33). Na análise ajustada, os 291 (6,7%) recém-nascidos com escorez de peso/idade e os 268 (6,2%) com índice de massa corporal (IMC)/idade < -2 DP tiveram, respectivamente, 27% (IC95%: 7-49) e 29% (IC95%: 10-51) maior risco de apresentar problemas de saúde mental aos 11 anos quando comparados com aqueles com escore normal. Os 102 (2,43%) recém-nascidos com escorez de IMC e os 279 (6,4%) com perímetro cefálico/idade > +2 DP tiveram, respectivamente, 34% (IC95%: 6-71) e 19% (IC95%: 1-40) maior risco de apresentar esses problemas se comparados com aqueles com escore normal. Os resultados sugerem que fatores ocorridos na gestação e refletidos nas medidas de tamanho ao nascer podem ocasionar problemas de saúde mental em etapas tardias.

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“…Moreover, insulin-like growth factor has a neuroprotective anti-apoptotic effect (Rizzo et al, 1991) and down regulation of expression of insulin-like growth factor and its receptor in diabetes might also be expected to lead to neuronal loss (Li et al, 2002;Russell & Feldman, 1999).…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study

Ghafari

Golalipour

2015

Int. J. Morphol.

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GHAFARI, S.; GOLALIPOUR, E. & GOLALIPOUR, M. J.Alterations of the giant pyramidal neurons (Betz cells) in brain cortex of rat offspring born from gestational diabetics dams: a morphometric study. Int. J. Morphol., 33(3):1120-1125, 2015. SUMMARY:A few studies reported the adverse effects of gestational diabetes on hippocampus and spinal cord of rat offspring. Giant pyramidal neurons are giant pyramidal neurons located in fifth layers of the gray matter in the primary motor cortex. Therefore, this study was conducted to determine the effect of gestational diabetes on the giant pyramidal neurons and the thickness of internal pyramidal layer in the brain cortex of rat offspring. On day 1 of gestation, 10 Wistar rat dams were randomly allocated into two control and diabetic groups. Five animals in diabetic group received 40 mg/kg/BW of Streptozotocin (intraperitoneally) and control animals received normal saline. We randomly selected six offspring of every subject in both groups at day 28, 56 and 84. Rat offspring were scarified and then coronal sections were taken from the right brain cortex and sections were stained with Cresyl violet. The density of giant pyramidal neurons in brain cortex and thickness of internal pyramidal layer of brain cortex were evaluated. In P28, P56, P84 the Betz cells density of brain cortex were significantly reduced from 107.6±6.2, 131.6±4.6 and 143.5±4.0 in controls to 84.96±2.1, 109.8±7.3 and 121.05±5.6 in cases (p<0.05), respectively. The thickness of the internal pyramidal layer of brain cortex in P28, 56 and P84 was significantly higher in gestational diabetic group in comparison with the control group (p<0.05). This study showed that uncontrolled gestational diabetes reduces the giant pyramidal neurons density and internal pyramidal layer thickness in brain cortex of rat offspring.

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Correlations between Antepartum Maternal Metabolism and Intelligence of Offspring

Abstract: Maternal diabetes during pregnancy may affect behavioral and intellectual development in the offspring. The associations between gestational ketonemia in the mother and a lower IQ in the child warrant continued efforts to avoid ketoacidosis and accelerated starvation in all pregnant women.

Cited by 662 publications

References 15 publications

The persistent effects of in utero nutrition shocks over the life cycle: Evidence from Ramadan fasting

The persistent effects of in utero nutrition shocks over the life cycle: Evidence from Ramadan fasting

Tamanho ao nascer e problemas de saúde mental aos 11 anos em uma coorte brasileira de nascimentos

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study

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