Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis

Abstract

IntroductionBone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E2), and magnesium (Mg[2+]) ion concentrations in postmenopausal osteoporotic women as compared to healthy postmenopausal subjects.Materials and methodsThe study included 132 women with postmenopausal osteoporosis and 81 healthy postmenopausal women without osteoporosis. Dual-energy X-ray absorptiometry scan assessed BMD at different skeleton sites. Serum levels of E2, BSAP, and TRAP-5b were measured by enzyme linked immunosorbent assay. Serum levels of Mg(2+) were determined using the colorimetric spectrometry technique.ResultsSerum levels of BTMs were significantly higher in osteoporotic women than in controls. BSAP has a moderate sensitivity (76.5%) and specificity (84.3%) (cutoff point 21.27 U/L). At a cutoff point of 3.45 U/L, TRAP-5b presented a sensitivity of 86.3% and a higher specificity of 90.6%. Osteoporotic patients showed significantly lower concentrations of serum Mg(2+) than the control group. Mg(2+) levels correlated positively with BMD values (r=0.747, P<0.0001). Furthermore, Mg(2+) concentrations correlated positively with E2 levels (r=0.684, P<0.0001). Spine BMD correlated negatively with BSAP levels (r=−0.36, P<0.0001).ConclusionOur study showed that BMD correlates negatively with BTMs and positively with E2 and Mg(2+) levels. TRAP-5b presents a good specificity in identifying patients with postmenopausal osteoporosis.

The Association Between the Concentration of Serum Magnesium and Postmenopausal Osteoporosis

“…Twenty articles were included for full-text assessment, from which 9 were excluded from the sample studies: two did not have data on serum Mg; four mentioned osteoporosis, but their main target was osteoporotic fractures; two involved patients administered with drugs that improved the concentration of serum Mg|; one compared the concentration of serum Mg between osteoporosis and osteopenia. We included a total of 11 eligible papers, representing 2,776 postmenopausal women from 16 case-control studies [ Figure 1 ; ( 6 , 8 , 23 – 31 )]. Among them, according to the age and the location of measurement, Okyay's study ( 26 ) was divided into six part.…”

Effect of estradiol on high glucose‑induced osteoblast injury

“…A previous study has demonstrated that bone mass in diabetic patients is significantly decreased, and the risk of fracture is increased (24). Estrogen reduction significantly increases the risk of OP (25,26). E2 the most potent estrogen; however, its role in diabetes-related OP is poorly understood.…”

Osteoporosis and the Potential of Cell-Based Therapeutic Strategies

“…In fact, this TRACP5b is accepted as a marker of both: the number of osteoclasts and their activity [48,49]. It presents low diurnal variability and is not affected by feeding [50], being typically increased in high bone turnover conditions [51]. There are specific immunoassays for serum TRACP5b detection, actually it has been proposed for the evaluation of BMD in women [52].…”