Correlations between Cerebral Monoamine Metabolism and Vigilance States in Experimental Magnesium Deficiency

Poenaru, S; Rouhani, S.; Durlach, J; Aymard, N; Belkahla, F.; Rayssiguier, Yves

doi:10.1159/000410581

Cited by 9 publications

(14 citation statements)

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“…However, the absence of modifica tion of PS (reduction or rebound) during Mg2+ deficiency or after Mg2+ recovery would suggest an effect on 5-HT storage rather than on 5-HT neurones involved in PS con trol. In fact, no reduction of 5-HT turnover was reported by Poenaru et al [ 14], Mg2+ deficiency produced electrophysiological effects that could suggest alterations at a cellular level. In fact, release of excitatory amino acid neurotransmitters like glutamate and aspartate might have ncurotoxic properties at high concentrations and participate in tissue damage caused by cerebral ischemia and brain injury [see 36.…”

Section: Discussionmentioning

confidence: 74%

“…In addition to overactiva tion of NMDA receptors, magnesium deficiency is also likely to lead to alterations of cerebral monoamine metab olism. Catecholamine release is facilited in Mg2+ defi ciency [14,35]. Facilitation of dopamine release has been shown to correlate well with high percentages of wakeful ness.…”

Section: Discussionmentioning

confidence: 99%

“…Facilitation of dopamine release has been shown to correlate well with high percentages of wakeful ness. Additionally, changes in 5-HT levels or metabolism [14] may explain the alterations and the fragmentation of SWS (effect also observed after />chlorophenylalanine treatment in rats [26]). However, the absence of modifica tion of PS (reduction or rebound) during Mg2+ deficiency or after Mg2+ recovery would suggest an effect on 5-HT storage rather than on 5-HT neurones involved in PS con trol.…”

Section: Discussionmentioning

confidence: 99%

“…Poenaru et al [14] reported an increase in wakefulness and decrease in sleep time during a Mg2+-restricted diet.…”

Section: Introductionmentioning

confidence: 97%

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Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Depoortere¹,

Françon²,

Llopis

1993

Neuropsychobiology

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The influence of magnesium, one of the most important cations in the vertebrate body, on the sleep-wakefulness cycle and ECoG patterns in chronically implanted rats recorded during the light period over a 6-hour period was investigated. Two groups of rats were studied. Group 1 (6 rats): after a control period of 2 weeks, the rats were maintained for 9 weeks on a Mg²⁺-deficient diet. Group 2 (5 rats): after a control period of 2 weeks, the rats were maintained for 7 weeks on a Mg²⁺-deficient diet followed by 4 weeks on a normal diet (recovery period: weeks 8–11). Mg²⁺-deficient diet for 9 weeks induced sleep and ECoG time-dependent alterations. After 6–7 weeks on a Mg²⁺-defi-cient diet (n = 11) sleep analysis showed a significant increase of wakefulness (+50%) at the expense of slow wave sleep (–24%) but paradoxical sleep was not significantly modified. After 9 weeks of a Mg²⁺ deficient diet, sleep was desorganized: light sleep and polyspikes occurred indicating an increase in neuronal excitability. When Mg²⁺ was reintroduced in food and water, sleep organization and ECoG recordings were restored to their original patterns. Our findings which are in line with previous clinical and pharmacological observations provide conclusive arguments for the neuroprotective effect of magnesium ions in neurologic disorders and epileptiform activity. Mg²⁺ deficiency induces ECoG alterations in the rat which bear some similarities with those seen in neurogenic spasmophilic syndromes in man.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Poenaru et al [14] reported an increase in wakefulness and decrease in sleep time during a Mg2+-restricted diet.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Depoortere¹,

Françon²,

Llopis

1993

Neuropsychobiology

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“…Experimental magnesium restricted diets in rats also increases the cerebral dopamine and norepinephrine concentration. This rise is associated with a decrease of sleep time and an increase in electroencephalographic wakefulness (Poenaru et al, 1984). Magnesium deficiency is accompanied by a decrease of sleep duration and by an increase of brain dopamine level (Chollet et al, 2000).…”

Section: Relationship Between Magnesium and Neurosesmentioning

confidence: 99%

Magnesium in the Central Nervous System

Turner

Vink

New Perspectives in Magnesium Research

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Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

Murck¹,

Steiger²

1998

Psychopharmacology

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Disturbances of Mg2+ metabolism have been reported in association with affective disorders, seizures in eclampsia, and alcohol withdrawal. Mg2+ has been reported to have N-methyl-D-aspartate (NMDA)-antagonistic and gamma-aminobutyric acid (GABA)-agonistic properties and modulation of GABA(A)- and NMDA-dependent systems is involved in pharmacological treatment of affective disorders and seizures. We studied the effect of Mg2+ on sleep electroencephalogram (EEG) and nocturnal hormonal secretion in men. Ten normal controls were given MgSO4 (3 g MgSO4 between 2030 hours and 2100 hours, followed by 0.5 g MgSO4 per hour until 0700 hours) or placebo i.v. according to a randomized schedule. The sleep EEG was recorded from 2300 hours to 0700 hours. Blood samples were taken from 2000 hours to 0700 hours for analysis of plasma corticotropin (ACTH), cortisol, growth hormone, prolactin and melatonin. The sleep-EEG power within the spindle frequency range (11.0-12.9 Hz) showed a significant increase in the third sleep cycle, but delta power was unchanged throughout the night. ACTH concentration was suppressed between 2200 hours and 0700 hours. No changes in cortisol, growth hormone prolactin or melatonin release were found. The findings are consistent with the assumption that Mg2+ has GABA(A)-agonistic or NMDA-antagonistic effects on sleep and nocturnal hormonal secretion and hence may be useful in controlling depressive symptoms and seizures.

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Correlations between Cerebral Monoamine Metabolism and Vigilance States in Experimental Magnesium Deficiency

Cited by 9 publications

References 0 publications

Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Effects of a Magnesium Deficient Diet on Sleep Organization in Rats

Magnesium in the Central Nervous System

Mg 2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men - possible therapeutic implications

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