Correlations between dynamic contrast‐enhanced magnetic resonance imaging–derived measures of tumor microvasculature and interstitial fluid pressure in patients with cervical cancer

Abstract

Purpose:To correlate permeability (rk trans ), extracellular volume fraction (rv e ), relative to muscle and initial area under the enhancement curve (IAUC 60m ) determined by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with in vivo measurements of interstitial fluid pressure (IFP) in patients with cervical cancer. Materials and Methods: DCE-MRI and IFP measurementswere performed of cervical tumors of 32 patients prior to therapy. Median tumor rk trans and rv e were derived from a bidirectional two-compartment model using an input function derived from muscle. Median IAUC 60m was defined as the integral of tumor enhancement in the first 60 seconds divided by the similar muscle enhancement integral. These parameters were correlated with the mean tumor IFP.Results: There was a significant negative correlation between IAUC 60m and IFP (r ϭ -0.42, P ϭ 0.016) and between rk trans and IFP (r ϭ -0.47, P ϭ 0.008). The was no significant correlation between IFP and rv e . Conclusion:There is a moderate negative correlation between IAUC 60m , rk trans , and IFP in cervical cancer. This suggests that these parameters may be of value in assessment of tumor behavior.

Hyperpolarized 13C Spectroscopy Detects Early Changes in Tumor Vasculature and Metabolism after VEGF Neutralization

“…Treatment of neuroblastoma xenografts with bevacizumab increased the penetration of a chemotherapeutic drug for 1 to 3 days after drug treatment (46), and a similar observation was made in HT29 tumors (47). A reduction in IFP may explain the increase in AUC 600 observed here because a negative correlation has been observed between AUC and IFP in cervical cancer, thought to be due to high IFP resulting in increased resistance to tumor blood flow (48). The failure to detect increased pyruvate concentrations in the HT29 tumors following bevacizumab treatment (Fig.…”

Increase in tumour permeability following TGF-β type I receptor-inhibitor treatment observed by dynamic contrast-enhanced MRI

“…Because of no significant difference in tumour cell shape after treatment ( Figure 3A), intra-cellular volume did not change. Decreased apparent diffusion coefficient, therefore, reflected a decrease in Furthermore, similar to negative correlation between tumour interstitial fluid pressure and permeability of tumour (Haider et al, 2007), IAUGC, K trans , and v p showed a moderate negative correlation to apparent diffusion coefficient, suggesting that these parameters may be providing similar information. As apparent diffusion coefficient is acquired in clinic widely to detect and diagnose a tumour, it could apply conveniently to examine the permeability of tumour in patients.…”

Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology

“…Among those 7 centres that use IV contrast medium, 6 use a dynamic acquisition and 1 uses a semidynamic one. The results of the literature are also variable with some authors using IV contrast medium systematically in all cases [10][11][12] whereas other authors not using IV contrast medium at all [13,14]. In a dynamic acquisition, contrast enhancement of the tumour is lower than the myometrium in the early phase, whereas on the late phases, tumour signal intensity is higher than the myometrium.…”