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Purpose:To correlate permeability (rk trans ), extracellular volume fraction (rv e ), relative to muscle and initial area under the enhancement curve (IAUC 60m ) determined by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with in vivo measurements of interstitial fluid pressure (IFP) in patients with cervical cancer. Materials and Methods: DCE-MRI and IFP measurementswere performed of cervical tumors of 32 patients prior to therapy. Median tumor rk trans and rv e were derived from a bidirectional two-compartment model using an input function derived from muscle. Median IAUC 60m was defined as the integral of tumor enhancement in the first 60 seconds divided by the similar muscle enhancement integral. These parameters were correlated with the mean tumor IFP.Results: There was a significant negative correlation between IAUC 60m and IFP (r ϭ -0.42, P ϭ 0.016) and between rk trans and IFP (r ϭ -0.47, P ϭ 0.008). The was no significant correlation between IFP and rv e . Conclusion:There is a moderate negative correlation between IAUC 60m , rk trans , and IFP in cervical cancer. This suggests that these parameters may be of value in assessment of tumor behavior.