Correlations between Molecular Mobility and Chemical Stability During Storage of Amorphous Pharmaceuticals

Polymer Combination Increased Both Physical Stability and Oral Absorption of Solid Dispersions Containing a Low Glass Transition Temperature Drug: Physicochemical Characterization and <i>in Vivo</i> Study

“…5,6) Oksanen and Zografi, Andronis et al, and Konno and Taylor found the physical stability of amorphous solid dispersions to be improved, in terms of molecular mobility and thermodynamic quantities at temperatures below the T g . [20][21][22] Hancock and Zografi reported that the T g should be at least 50°C above the storage temperature to ensure that the product remains stable over its shelf-life.…”

“…Hancock et al and Yoshioka and Aso demonstrated that molecular mobility is an important factor affecting the chemical stability of amorphous state. 5,6) Above the glass transition temperature (T g ), molecular mobility leads to rapid nucleation and crystal growth. Amorphous solid dispersions with relatively low T g are more mobile and have a higher potential for crystallization.…”

Investigating therapeutic usage of combined Ticagrelor and Aspirin through solid-state and analytical studies

“…Hence, it is clear that the acetylation of TIC plays an important role in its degradation process. Furthermore, contrary to the solid state, where the chemical interactions only slowly evolved, the liquid state gives almost immediately rise to one of the main degradation products, which next to the increased thermal activation energy, can be ascribed to the increase of the molecular mobility of the two APIs in the liquid [30]. However, the TIC-ASA physical mixture heated for seven days at 100°C revealed a few clear changes (Fig 6a spectrum e, Table S2):…”

Influence of Manufacturing Factors on Physical Stability and Solubility of Solid Dispersions Containing a Low Glass Transition Temperature Drug

“…4,5) Hancock et al stated that the T g of amorphous solid dispersions of drugs should be at least 50°C above the expected storage temperature to ensure that the product remains stable over its shelf life. 19) The distinctive single T g of the solid dispersions was obtained.…”

“…Previous studies have reported that one important factor affecting the physical stability of the amorphous state is molecular mobility, with high molecular mobility leading to rapid nucleation and crystal growth. 4,5) Glass transition temperature (T g ), which delineates a temperature range between high and low molecular mobility, is a critical parameter affecting the molecular mobility of amorphous state compounds; solid dispersions with low T g have relatively high molecular mobility, which can subsequently lead to rapid nucleation and crystal growth above the T g . 6) Numerous studies have investigated the physical stability of amorphous solid dispersions in terms of molecular mobility and thermodynamic quantities at temperatures below T g .…”