Correlations between Peak Nasal Inspiratory Flow, Acoustic Rhinometry, 4-Phase Rhinomanometry and Reported Nasal Symptoms

Ottaviano, Giancarlo; Pendolino, Alfonso Luca; Scarpa, Bruno; Torsello, Miriam; Sartori, Daniele; Savietto, Enrico; Cantone, Elena; Nicolai, Piero

doi:10.3390/jpm12091513

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…Different studies have compared PNIF with other objective methods for the measurement of nasal obstruction, finding a correlation among them [ 13 , 14 ]. In particular, a very recent study demonstrated PNIF to better correlate with the patients’ perception of nasal obstruction than both AR and four-phase RM [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab

Ottaviano

Corso

Cantone

et al. 2023

JPM

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Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin’ Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients’ response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (p < 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (p < 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (p < 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients’ response to dupilumab.

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Section: Introductionmentioning

confidence: 99%

Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab

Ottaviano

Corso

Cantone

et al. 2023

JPM

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“…Furthermore, analyzing the correlations between the reported nasal symptom and the objective measures, only PNIF was correlated (mildly) with visual analogue scale (VAS) for nasal obstruction. 69 PNIF has been found to be more sensitive than the other measures (posterior active RM and AR) in evaluating the response to topical corticosteroids after histamine nasal challenge test in patients affected by perennial allergic rhinitis. 78 Considering patients undergoing septoplasty, some authors tried to compare postoperative surgical success by means of RM, AR, and PNIF measurements and patient satisfaction (evaluated by VAS and NOSE) according to nasal septal deviation type.…”

Section: Acoustic Rhinometry In Clinical Practicementioning

confidence: 95%

“…67,68 Apart from AR, the most known are rhinomanometry (RM) and peak nasal inspiratory flow (PNIF). 25 Comparing AR with RM, significant correlations have been found between MCA and nasal resistances in healthy and obstructed noses, 69 in adults and children, especially when unilateral measurements have been studied. 60,70,71 AR and RM results have been found to give comparable results during nasal challenge tests.…”

Section: Acoustic Rhinometry In Clinical Practicementioning

confidence: 99%

Nasal Patency Measurement: State of the Art of Acoustic Rhinometry

Ottaviano

2023

Facial Plast Surg

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Nasal obstruction is one of the main symptoms of different nasal pathologies. Many physiologic and pathologic conditions can produce nasal airflow impairment causing nasal obstruction and affecting patients’ quality of life. There are different methods for the measurement of nasal obstruction, but in clinical practice the most common used are acoustic rhinometry, rhinomanometry and peak nasal inspiratory flow. This review describes the fundamental of acoustic rhinomanometry, its normal values, the different physiologic and pathologic conditions that can modify nasal patency and the utility of this instrument for the measurement of nasal obstruction in clinical practice. Acoustic rhinometry is a simple test, so it is suitable for measurements in the pediatric population, i.e. for evaluating adenoid hypertrophy. Acoustic rhinometry normal values are available, unilaterally and bilaterally for pediatric and adult populations. Acoustic rhinometry has been demonstrated to be reproducible and even superior to rhinomanometry when measuring nasal modifications during challenges. It is possible to use acoustic rhinometry before and after nasal surgery. Measuring nasal cavities volume and cross-sectional area, acoustic rhinometry is particularly indicated in rhinosurgery, especially for the evaluation of spreader grafts. Brief considerations about the correlation between nasal symptoms, in particular the subjective sensation of nasal obstruction, and the acoustic rhinometry results as well as the correlation of acoustic rhinometry with other methods for the measurement of nasal obstruction are also reported. Objective and subjective evaluation of nasal obstruction gives different information that together optimizes the diagnosis and the treatment of rhinologic patients. Acoustic rhinometry alone or in combination of other instruments for the measurement of nasal obstruction or patency should be used regularly in every outpatient clinic that treats patients with nasal obstruction as there is an increasing need of evidence-based therapies.

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“…1 The correlation of PNIF values with VAS-NO and NOSE questionnaire has been demonstrated, making it a valuable test to combine with these subjective evaluation tools. 1,37 An important remark is that PNIF measurements cannot be taken if nasal collapse occurs or in very serious obstructions. 1…”

Section: Objective Evaluation Of Nasal Flowmentioning

confidence: 99%

“…17 Also, there is no significant correlation between 4PRMM and the VAS-NO score, while this is the case for RMM and VAS-NO. 37 AcR uses acoustic reflection to explore the geometry of the nasal cavity. 1,36 It is a quick, direct, and simple tech-nique.…”

Section: Quantification Of Nasal Flowmentioning

confidence: 99%

Nasal Obstruction: Overview of Pathophysiology and Presentation of a Clinically Relevant Preoperative Plan for Rhino(Septo)plasty

Snoeks,

Velasco,

Talavera

et al. 2024

Facial Plast Surg

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Impairment of nasal breathing is a highly prevalent and bothersome symptom that affects daily functioning and/or sleep quality. Those surgeons dealing with patients seeking rhinoplasty need to carefully analyze the preoperative nasal breathing capacity and predict the positive or even negative impact of rhino(septo)plasty on nasal breathing. Given the lack of correlation between the subjective feeling of suboptimal nasal breathing and the objective measurements of nasal flow and nasal resistance, a critical and mainly clinical evaluation of all anatomical, mucosal, and sensory mechanisms involved in nasal obstruction is mandatory. Indeed, thermo-, mechano-, and chemosensory receptors on the nasal mucosa, airflow, and respiratory dynamics might all contribute to the overall perception of nasal breathing capacity. In this review, we provide an overview of the factors determining suboptimal nasal breathing including different diagnostic and experimental tests that can be performed to evaluate nasal flow and nasal resistance and current limitations in our understanding of the problem of nasal breathing in an individual patient. An algorithm for the preoperative or diagnostic workup for nasal obstruction is included that might be useful as a guide for clinicians dealing with patients seeking nose surgery.

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Correlations between Peak Nasal Inspiratory Flow, Acoustic Rhinometry, 4-Phase Rhinomanometry and Reported Nasal Symptoms

Cited by 9 publications

References 41 publications

Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab

Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab

Nasal Patency Measurement: State of the Art of Acoustic Rhinometry

Nasal Obstruction: Overview of Pathophysiology and Presentation of a Clinically Relevant Preoperative Plan for Rhino(Septo)plasty

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