2009
DOI: 10.1080/13547500902836032
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Correlations between plasma levels of a fibronectin isoform subpopulation and C-reactive protein in patients with systemic inflammatory disease

Abstract: Surrogate markers to detect vasculitic processes prior to organ compromise are lacking. To determine if specific populations among the fibronectin (FN) family of alternatively spliced proteins correlate with parameters of vasculitis in at-risk patients, we retrospectively evaluated the association of plasma levels of total FN (TFN) and FN bearing the alternatively spliced EIIIA segment (A + FN) with clinical vasculitis status and with levels of two putative vasculitis markers (C-reactive protein [CRP] and von… Show more

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Cited by 5 publications
(2 citation statements)
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“…Plasma FN lacks both EIIIA and EIIIB segments and is a soluble form secreted by hepatocytes, whereas cellular FN contains variable proportions of EIIIA and EIIIB segments and is found as fibrils in the ECM . Increased expression of the EIIIA + and EIIIB + isoforms of FN are associated with physiological or pathological tissue remodeling, including wound healing , tissue fibrosis , fibroblast differentiation , inflammation and tumor progression .…”
Section: Introductionmentioning
confidence: 99%
“…Plasma FN lacks both EIIIA and EIIIB segments and is a soluble form secreted by hepatocytes, whereas cellular FN contains variable proportions of EIIIA and EIIIB segments and is found as fibrils in the ECM . Increased expression of the EIIIA + and EIIIB + isoforms of FN are associated with physiological or pathological tissue remodeling, including wound healing , tissue fibrosis , fibroblast differentiation , inflammation and tumor progression .…”
Section: Introductionmentioning
confidence: 99%
“… 5 , 6 Since the vast bulk of pFN is produced by hepatocytes, which do not normally express EDA or EDB, 1 pFN in healthy subjects is nearly devoid of these segments. 7 In contrast, endothelial cells synthesize and secrete a mixture of FN isoforms in which EDA and EDB segments are included in ∼15%–40% of total synthesized FN monomers. 8 , 9 Such production may contribute to the low concentrations of EDA + FN (A + FN) and EDB + FN (B + FN) that have been detected in the plasma of healthy individuals (accounting <∼1% of the total circulating pool of FN).…”
Section: Introductionmentioning
confidence: 99%