Surrogate markers to detect vasculitic processes prior to organ compromise are lacking. To determine if specific populations among the fibronectin (FN) family of alternatively spliced proteins correlate with parameters of vasculitis in at-risk patients, we retrospectively evaluated the association of plasma levels of total FN (TFN) and FN bearing the alternatively spliced EIIIA segment (A + FN) with clinical vasculitis status and with levels of two putative vasculitis markers (C-reactive protein [CRP] and von Willebrand factor) in a previously-studied cohort of 27 patients with systemic inflammatory disease. We found that the percentage of TFN comprised by A + FN (%A + ) and A + FN, but not TFN, correlated with plasma levels of CRP, the prototypic inflammation biomarker used to detect vasculitis. These findings suggest that different FNs may confer distinct clinical information, and that their simultaneous measurement merits further investigation in our efforts to identify soluble biomarker systems to detect vasculitis.