Correlations between serum lipids and complement components in adults without demonstrated atherosclerotic disease

Increased Serum IgA Levels in Subjects with Previous Myocardial Infarction or Other Major Ischemic Events

“…Although age and sex may affect IgA levels [10], no significant differences were found when age and sex subgroups of the IgA values from the 179 subjects selected in this study were compared by variance analysis.…”

“…Further more, in control subjects serum IgA levels progressively increase with age, and earlier in males than in females [10], thus paralleling the natural course of atherosclerotic diseases. Finally, further interest in IgA antibodies comes from a study by Beaumont et al [11], who showed the presence of circulating li poprotein-containing immune complexes, mainly of IgA class, in the sera from hyperlipidemic patients with xanthomatosis and atherosclerosis.…”

The role of complement factor C3 in lipid metabolism

“…Many factors can regulate at multiple levels C3a-desArg production and C3a-desArg action. In particular, C3a-desArg decreases with weight loss in obese subjects (Muscari et al, 1990) and is acutely regulated by physical activity and fitness (Artero et al, 2014;Dufaux and Order, 1989;Smith et al, 1990). Furthermore, several commonly prescribed lipid-lowering and glucose-lowering drugs are shown to have an effect on C3a-desArg and/or C3 levels (Hotamisligil and Spiegelman, 1994;Oktenli et al, 2007;Scantlebury et al, 1998), effect which might be direct on C3a-desArg production and/or activity or mediated via increased insulin sensitivity or decreased inflammatory molecules.…”

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

“…In addition, KO mice had reduced circulating leptin, insulin, and glucose levels suggesting that ASP deletion may exert indirect effects to improve glucose homeostasis and protect against the detrimental effects of high-fat feeding (456). Similar to other adipose secreted factor, levels of adipsin and C3 are reduced following diet-induced weight loss in obese subjects (458,509). The direct cause underlying this reduction remains to be delineated.…”