Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease

Alsagaff, Mochamad Yusuf; Pikir, Budi Susetyo; Thaha, Mochammad; Susilo, Hendri

doi:10.18585/inabj.v12i3.1241

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…In addition, non-traditional risk factors such as oxidative stress and inflammation also contribute to the high prevalence of CKD [ 7 , 8 ]. Chronic kidney disease is linked to homeostatic deregulation of soluble molecule synthesis, release, and degradation, as well as immune system disturbances caused by disruption of cytokines and inflammatory mediators, and decreased renal clearance, which results in higher levels of circulating cytokines [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Susilo

Pikir

Thaha

et al. 2022

Genes

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The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and plasma ACE levels may allow for the optimization of a preventive intervention to reduce cardiovascular morbidity and mortality in the chronic kidney disease (CKD) population. In this study, we aimed to analyze the association between ACE I/D polymorphism and cardiovascular mortality risk among non-hemodialyzed chronic kidney disease patients. This cross-sectional study examined 70 patients of Javanese ethnic origin with stable CKD who did not receive hemodialysis. ACE I/D polymorphisms, plasma ACE levels, atherosclerotic cardiovascular disease (ASCVD) risk, and cardiovascular mortality risk were investigated. As per our findings, the I allele was found to be more frequent (78.6) than the D allele (21.4), and the DD genotype was less frequent than the II genotype (4.3 vs. 61.4). The ACE I/D polymorphism had a significant direct positive effect on plasma ACE levels (path coefficient = 0.302, p = 0.021). Similarly, plasma ACE levels had a direct and significant positive effect on the risk of atherosclerotic cardiovascular disease (path coefficient = 0.410, p = 0.000). Moreover, atherosclerotic cardiovascular disease risk had a significant positive effect on cardiovascular mortality risk (path coefficient = 0.918, p = 0.000). The ACE I/D polymorphism had no direct effect on ASCVD and cardiovascular mortality risk. However, our findings show that the indirect effects of high plasma ACE levels may be a factor in the increased risk of ASCVD and cardiovascular mortality in Javanese CKD patients.

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Section: Introductionmentioning

confidence: 99%

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Susilo

Pikir

Thaha

et al. 2022

Genes

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“…Oxidative stress has been linked to vascular stiffness in diabetics. Alterations in vascular function may be caused by increased oxidative stress and decreased anti-oxidant defense mechanisms [36,37]. Arteriosclerosis is immediately associated with structural changes in the tunica media, including elastin fragmentation and calcification.…”

Section: Discussionmentioning

confidence: 99%

Type II Diabetes as the Main Risk Factor of Arterial Stiffness in Chronic Kidney Disease Patients

Susilo

Alsagaff

Pikir

et al. 2022

2022 6th International Conference on Medical and Health Informatics

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Chronic kidney disease (CKD) is frequently linked to an increased risk of cardiovascular disease. Diabetes, hypertension, dyslipidemia, and obesity are all traditional risk factors of cardiovascular disease in CKD. However, the contribution of each of the traditional risk factors to arterial stiffness is unknown. This was a correlational study with a cross-sectional design. This study included forty CKD patients from Universitas Airlangga Hospital Surabaya, between December 2019 until March 2020. Serum samples were used to measure laboratory parameters, and Doppler ultrasound was used to assess carotid-femoral Pulse Wave Velocity (cfPWV). Spearman's analysis was conducted to determine correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. Mann-Whitney test was performed to determine the association between type II diabetes with cf-PWV. Significant results were continued with linear regression analysis model. There were significant correlations between cf-PWV and e-GFR, HBA1C, serum creatinine, and cystatin-C. HBA1C showed the most significant positive correlation with a moderate correlation coefficient (p = 0.000; r = 0.581). Patients with type II diabetes was associated with increased cf-PWV. Linear regression model also revealed that HBA1C and history of diabetes were significant predictors of increased cf-PWV in CKD patients (β = 0.400; p = 0.011 and β = 0.537; p = 0.000, respectively). We found a positive correlation between HBA1C and cf-PWV and

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“…Theoretically, there was a correlation between 8-OHdG and NO in CKD, caused by oxidative stress (Alsagaff et al 2020). Peroxynitrite formed due to the reaction between NO and O2 increases RNS cytotoxic.…”

Section: Hi I Tmentioning

confidence: 98%

8-Hydroxydeoxyguanosine Urine and Total Nitric Oxide Serum in Chronic Kidney Disease

Ahadini

Thaha

Mustika

2022

FMI

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Highlights: Oxidative markers 8-Hydroxydeoxyguanosine and Nitric Oxide was found high in hemodialysis and non-hemodialysis chronic kidney disease patients. There is no correlation between 8-Hydroxydeoxyguanosine and Nitric Oxide in hemodialysis and non-hemodialysis chronic kidney disease patients. Abstract: Oxidative stress is essential to chronic kidney disease (CKD). Several markers include 8-Hydroxydeoxyguanosine (8-OHdG) and Nitric Oxide (NO). Reactive oxygen species (ROS) and Reactive Nitrogen Species (RNS) increased in CKD and had a role in renal impairment progressivity. There are some controversies regarding oxidative markers in CKD patients in several studies. This study aimed to understand oxidative markers 8-OHdG and NO and explained the correlation of both markers in hemodialysis and non-hemodialysis CKD patients. Twenty hemodialysis patients and forty-nine non-hemodialysis patients were enrolled in this cross-sectional study. Urine patients were collected to measure 8-OHdG using the enzyme-linked immunoassay (ELISA) method, and NO was measured from serum patients using the Griss Saltzman method. Based on Bivariate Pearson analysis, there was no significant correlation between 8-OHdG urine and total NO serum in the hemodialysis group (p= 0,510, p>0.05) and in the non-hemodialysis group (p= 0.801, p>0,05). In this study, DNA oxidative marker, 8-OHdG, was not correlated with NO in CKD patients.

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Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease

Cited by 6 publications

References 34 publications

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level

Type II Diabetes as the Main Risk Factor of Arterial Stiffness in Chronic Kidney Disease Patients

8-Hydroxydeoxyguanosine Urine and Total Nitric Oxide Serum in Chronic Kidney Disease

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