Correlations between whole body volumetric parameters of 68Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients

Yıldırım, Özgen Ahmet; Gündoğan, Cihan; Can, Canan; Poyraz, Kerem; Erdur, Erkan; Kömek, Halil

doi:10.1007/s12149-021-01594-8

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…In the study of Schmidkonz et al on PCa patients with BM, signi cant correlations were found between quantitative volumetric tumor parameters of metastases with GS and PSA levels [14]. Similarly, in a study by Yildirim et al, they indicated that the volumetric parameters might be helpful in distinguishing patients who will show a rapid relapse [24]. In our study, we preferred to take into account volumetric measurements of the primary prostate lesion of newly diagnosed patients.…”

Section: Discussionmentioning

confidence: 77%

Relationship Between Initial Volumetric 68Ga-PSMA PET/CT Parameters, and Clinical and Histopathological Data in Patients with Newly Diagnosed Prostate Cancer

MÜTEVELİZADE,

Arıkbası,

Parlak

et al. 2023

Preprint

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Purpose: To evaluate the relationships between volumetric 68Ga-PSMA PET/CT parameters, Gleason Score (GS), Gleason Grade (GG), PSA levels, histopathological data, and metastatic status in newly diagnosed prostate cancer (PCa) patients. Methods: A total of 78 newly diagnosed PCa patients who had 68Ga-PSMA PET/CT scan were included in this study. Clinical parameters, histopathological data, and metastatic status were documented, volumetric parameters were measured. All obtained data were compared statistically. Results: Gleason Score, GG, and SUVmax had a significant relationship with serum PSA levels (p<0.05). PSA levels and SUVmax values of patients with lymph node metastases were found to be significantly higher than those without. GG and the sum of GS were found to be statistically significantly increased in metastatic patients. PSMA-TV and TL-PSMA of the primary lesion, have a significant relationship with PSA value, GS, and regional lymph node metastases. When the relationships between histopathological data with PSA level, GG, SUVmax, PSMA-TV, and TL-PSMA were compared; A significant correlation was observed between all except PNI and TL-PSMA. ROC analysis was performed in patients with metastatic and localized disease, and the cutoff value for SUVmax was found to be 10.85. Conclusion: Correlations between PSA values and GG, lymph node metastasis, SUVmax, and histopathological data support the crucial role of 68Ga-PSMA PET/CT in the initial evaluation of PCa patients. In our study, we concluded that 68Ga-PSMA PET/CT is an effective tool and the effects of clinical, histopathological, and imaging-based parameters in prostate cancer patients should be well known.

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Section: Discussionmentioning

confidence: 77%

Relationship Between Initial Volumetric 68Ga-PSMA PET/CT Parameters, and Clinical and Histopathological Data in Patients with Newly Diagnosed Prostate Cancer

MÜTEVELİZADE,

Arıkbası,

Parlak

et al. 2023

Preprint

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“…A study of 88 patients undergoing initial staging for prostate cancer reported a moderate correlation between serum PSA and PSMA-TV and a high correlation between TL-PSMA and serum PSA 58 . Other studies have shown that both PSMA-TV and TL-PSMA correlate well with Gleason score and are good predictors of progression-free survival 59,60,61 . PSMA-TV and TL-PSMA have also been shown to be beneficial in the context of treatment response assessment, in which changes in both parameters are concordant with PSA changes (biochemical response) following treatment 62,63,64,65 In a study of 19 prostate cancer patients treated with Lu-177 PSMA I&T, PSMA-TV values were decreased in 12 patients (63%), and TL-PSMA values were decreased in 15 patients (79%) following treatment.…”

Section: [H2]psma-derived Tumour Volume and Total Lesion Psmamentioning

confidence: 94%

“…American Society of Clinical Oncology (ASCO) guidelines recommend the use of NGIs in the evaluation of high-risk locally advanced prostate cancer, in which conventional imaging is negative, indeterminate or suspicious 14 . A number of studies [15][16][17][18][19] have shown that PSMA-PET outperforms conventional imaging in identifying nodal and metastatic bone disease, with up to 27% greater diagnostic accuracy (92% [88][89][90][91][92][93][94][95] versus 65% [60][61][62][63][64][65][66][67][68][69]; p<0•0001) compared with conventional CT and bone scan. In a 2020 systematic review including 18 trials and 969 patients assessing PSMA PET for primary lymph node staging 18 , the weighted sensitivity, weighted specificity and positive predictive values were 59%, 93% and 20-100% (greater than 80% in the majority of trials), respectively (compared with 42%, 82% and 32% for CT).…”

Section: [H2]newly Diagnosed High-risk Diseasementioning

confidence: 99%

The future of PSMA PET and WB MRI as next-generation imaging tools in prostate cancer

et al. 2022

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Radiolabelled prostate-specific membrane antigen (PSMA)-based Positron emission tomography-computed tomography (PET-CT) has been shown in numerous studies to be superior to conventional imaging in the detection of nodal or distant metastatic lesions. 68Ga-PSMA PET-CT is now recommended by many guidelines for the detection of biochemically relapsed disease after radical local therapy. PSMA radioligands can also function as radiotheranostics, namely Lu-PSMA has been shown to be a potential new line of treatment for metastatic castrate resistant prostate cancer. W hole-body MRI (WB-MRI) has been shown to have a high diagnostic performance in the detection and monitoring of metastatic bone disease. Prospective, randomized, multi-centre studies comparing 68 Ga-PSMA PET-CT and WB-MRI for pelvic nodal and metastatic disease detection are yet to be performed. Challenges for interpretation of PSMA include tracer trapping in non-target tissues and urinary excretion of tracers confounding image interpretation at the vesicoureteral junction. Additionally , studies have described how long-term androgen deprivation therapy (ADT) affects PSMA expression and could, therefore, reduce tracer uptake and visibility of PSMA-positive lesions . Furthermore, ADT of short duration might increase PSMA expression, leading to the PSMA flare phenomenon, which makes it challenging to accurately monitor treatment response to ADT with PSMA-PET. Scan duration, detection of incidentalomas and presence of metallic implants are some of the major challenges with WB-MRI. Emerging data supports the wider adoption of PSMA-PET and WB-MRI for diagnosis, staging, disease burden evaluation and response monitoring, though their relative roles in the standard of care management of patents is yet to be fully defined.. Key points• Next-generation imaging techniques have been found to affect prostate cancer disease state classifications as their increased sensitivity can result in stage migration.

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“…< 1 ng/ml) [7][8][9][10][11]. PSMA is a transmembrane glycoprotein highly expressed in the majority of prostate cancers and its expression is generally positively correlated to the PSA value and to a lesser extent to other factors such as PSA doubling time, Gleason Score and hormonal status [12][13][14][15][16]. However, during treatment, an inconsistency between PSA value (decreased) and disease status (PD) detected by PSMA PET/CT is possible.…”

Section: Introductionmentioning

confidence: 99%

Discrepancy between Biochemical and Radiological Response in Metastatic Hormone- Sensitive Prostate Cancer: A Case Report and Literature Review

2023

Ann Case Report

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Correlations between whole body volumetric parameters of 68Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients

Cited by 7 publications

References 33 publications

Relationship Between Initial Volumetric 68Ga-PSMA PET/CT Parameters, and Clinical and Histopathological Data in Patients with Newly Diagnosed Prostate Cancer

Relationship Between Initial Volumetric 68Ga-PSMA PET/CT Parameters, and Clinical and Histopathological Data in Patients with Newly Diagnosed Prostate Cancer

The future of PSMA PET and WB MRI as next-generation imaging tools in prostate cancer

Discrepancy between Biochemical and Radiological Response in Metastatic Hormone- Sensitive Prostate Cancer: A Case Report and Literature Review

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