Correlations of Circadian Rhythm Disorder of Blood Pressure with Arrhythmia and Target Organ Damage in Hypertensive Patients

Abstract

The aim of this study was to investigate the correlations of circadian rhythm disorder of blood pressure with arrhythmia and target organ damage in hypertensive patients. Material/Methods: A total of 198 patients admitted and treated in our hospital from May 2018 to April 2019 were selected to receive 24-h ambulatory blood pressure monitoring. The nighttime blood pressure decrease rate is 0-10% in people with normal circadian rhythm of blood pressure. In the present study, we divided patients into a normal circadian rhythm group (normal circadian rhythm of blood pressure, n=132) and a circadian rhythm disorder group (circadian rhythm disorder of blood pressure, n=66) according to the circadian rhythm of blood pressure. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean pulse pressure (PP) were observed, and dynamic electrocardiography was performed to observe the status of arrhythmia. Finally, the degree of damage to target organs such as heart, brain, and kidney was compared. Results: The circadian rhythm disorder group had remarkably higher daytime SBP (d-SBP), daytime DBP (d-DBP), and daytime PP (d-PP) but clearly lower nighttime SBP (n-SBP), nighttime DBP (n-DBP), and nighttime PP (n-PP) than in the normal circadian rhythm group (P<0.0001). The detection rate of arrhythmia and the degree of target organ damage were clearly higher in the circadian rhythm disorder group compared with the normal circadian rhythm group (P<0.0001). Moreover, the incidence rates of heart disease, cerebrovascular disease, and nephropathy were higher in the circadian rhythm disorder group than in the normal circadian rhythm group (P<0.0001). Conclusions: The circadian rhythm disorder of blood pressure in hypertensive patients probably increases the risk of arrhythmia and worsens the target organ damage, so attention should be paid to the adjustment of disordered blood pressure rhythm in hypertensive patients in clinical practice.

Effect of Liuzijue exercise in different periods on circadian rhythm of blood pressure in patients with essential hypertension: A randomized trial

“…The latter increases the risk of stroke, renal dysfunction, and left ventricular hypertrophy and aggravates the damage to the cardiovascular system, kidney, and other organs. [ 10 ] Therefore, some researchers have proposed the organic integration of hypertension treatment plans with the circadian rhythm of blood pressure fluctuation4. By adjusting the treatment timing, correcting the abnormal blood pressure circadian rhythm, and considering the antihypertensive effects, the objective is to attenuate target organ damage and effectively prevent and treat associated diseases.…”

Influence of ambulatory blood pressure-related indicators within 24 h on in-hospital death in sepsis patients

“…DBPF was related to the risk of in-hospital death, and a negative correlation was obvious below 0%. Healthy people exhibit obvious circadian rhythms in the blood pressure 22 , with the blood pressure being higher during the daytime and lower at night. This is related to circadian rhythm changes of the sympathetic nerve and vagus nerve, as well as regulation of the body fluid hormone secretion rhythm in the human body.…”

Role of Circadian Rhythm and Impact of Circadian Rhythm Disturbance on the Metabolism and Disease

“…Compared with the normal circadian rhythm, the prevalence of cardiocerebrovascular and kidney disease in the circadian rhythm disorder group was significantly higher, and the left ventricular hypertrophy index and creatinine clearance rate were significantly reduced. 84 In this review, we discuss the interaction between circadian rhythms and common cardiovascular diseases, such as hypertension, obesity, and diabetes. In addition, we have systematically analyzed the causes and status of the diseases in the case of circadian rhythm disorders, as well as how to use the circadian rhythm to better prevent and intervene in the disease.…”

“…Furthermore, circadian rhythm disorder of blood pressure induces left ventricular hypertrophy and left atrial enlargement. 84 Circadian misalignment between the internal and external environments abnormally regulates blood pressure. One manifestation is that light-at-night exposure causes circadian rhythm disorder, resulting in increased nighttime blood pressure in elderly individuals.…”

“…94 Moreover, it can induce serious arrhythmias and target organ damage. 84 Zeng et al indicated that circadian rhythm disorder of blood pressure may be related to the strengthened stress sensitivity of sympathetic nervous system activity and decreased vagus nerve function in patients. Furthermore, circadian rhythm disorder of blood pressure induces left ventricular hypertrophy and left atrial enlargement.…”