Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

Anan, Futoshi; Masaki, Takayuki; Umeno, Yoshikazu; Iwao, Tetsu; Yonemochi, Hidetoshi; Eshima, Nobuoki; Saikawa, Tetsunori; Yoshimatsu, Hironobu

doi:10.1530/eje-07-0388

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…In contrast to previous studies we found no association of PWV with glycemic control in T2DM patients [9,21,43,44]. Furthermore, although inflammation, as assessed by hs-CRP, has been suggested to related to increased PWV in healthy subjects [45] as well as in hypertensive [46] and T2DM [47] patients, this has not been replicated in our study.…”

Section: Discussioncontrasting

confidence: 99%

Determinants of vascular function in patients with type 2 diabetes

Naka

Papathanassiou

Bechlioulis

et al. 2012

Cardiovasc Diabetol

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BackgroundType 2 diabetes mellitus (T2DM) is independently associated with an increased risk for cardiovascular diseases that is primarily due to the early development of advanced atherosclerotic vascular changes. The aim of our study was to investigate the predictors of vascular dysfunction in T2DM patients.MethodsWe studied 165 T2DM patients without known macrovascular or microvascular disease. Standard demographic (age, gender, cardiovascular risk factors, medications), clinical (body mass index, blood pressure) and laboratory (glucose, glycated hemoglobin, lipids, renal function) parameters were included in analyses. Brachial artery flow-mediated dilation (FMD), nitrate mediated dilation (NMD) and Carotid-Femoral Pulse Wave Velocity (PWV) were measured.ResultsMedian age was 66 years and duration since T2DM diagnosis was 10 years, 70% were females and 79% hypertensives, while only 10% had a glycated hemoglobin <7%. FMD was positively associated with NMD (r 0.391, P < 0.001), while PWV was inversely associated with FMD (r -0.218, P = 0.014) and NMD (r -0.309, P < 0.001). Time since diagnosis of diabetes was the single independent predictor of FMD (β -0.40, P = 0.003). Increased age and fasting glucose and the presence of hypertension were independent predictors of decreased NMD (P < 0.001). Increased age and systolic blood pressure were independently associated with increased PWV (P < 0.001).ConclusionsIn T2DM patients, impairment of endothelium-dependent vasodilation was independently associated only with longer diabetes duration while no association with other established risk factors was found. Vascular smooth muscle dysfunction and increased arterial stiffness were more prominent in older T2DM patients with hypertension. Worse glycemic control was associated with impaired vascular smooth muscle function.

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Section: Discussioncontrasting

confidence: 99%

Determinants of vascular function in patients with type 2 diabetes

Naka

Papathanassiou

Bechlioulis

et al. 2012

Cardiovasc Diabetol

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“…It should be emphasized that in all patients included in the study, the presence of any medical condition with features of inflammation was excluded, and ESR and leukocyte count were within normal limits. These results are consistent with data reported by other authors [5, 22–26]. …”

Section: Discussionsupporting

confidence: 94%

Increased Concentration of C-Reactive Protein in Obese Patients with Type 2 Diabetes Is Associated with Obesity and Presence of Diabetes but Not with Macrovascular and Microvascular Complications or Glycemic Control

et al. 2013

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Abstract-The purpose of this study was to assess the concentration of C-reactive protein (CRP) in obese type 2 diabetes mellitus (DM2) patients and its association with macrovascular and microvascular complications. The study group consisted of 80 obese DM2 patients, including 20 macrovascular, 20 microvascular, 20 both macrovascular and microvascular, and 20 with no complications patients. The control group comprised 40 normoglycemic subjects-20 obese and 20 of normal body weight. Highly sensitive CRP and metabolic control parameters were assessed. CRP levels in obese diabetes subgroups and normoglycemic obese were similar and significantly higher than those in nonobese controls. No correlation was found between CRP and diabetes control parameters. There was a strong positive correlation between CRP level and body mass index in all groups. A multivariate analysis showed that DM2 and obesity are independent factors increasing CRP levels. Increased concentration of CRP in obese DM2 patients is related to obesity and diabetes itself. The lack of association between CRP and vascular complications remains unclear.

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“…5,6 Hs-CRP was not associated with PWV in Europeans with T2DM, 7,8 but associated with PWV in Asians with T2DM. 9,10 Yoon et al 3 reported positive association of sRAGE with PWV in T2DM, while we found negative association in normalbuminuric T2DM in this cohort. 11 Therefore, we aim to examine the association between hs-CRP and sRAGE with PWV and AI in a large multi-ethnic T2DM Asian cohort.…”

Section: Introductioncontrasting

confidence: 42%

“…7 In two studies reporting positive association, the median hs-CRP level of 4.5 mg/L or <1 mg/L is markedly different from our study. 9,10 The difference in hs-CRP levels ascribed to subject-selection (i.e. sampling-frame) and arterial stiffness measurement may all contribute to the discrepancy in the results.…”

Section: Discussionmentioning

confidence: 99%