Correlations of In Vitro Assays for Assessing Cytotoxicity and Biocompatibility of Contact Lens Multipurpose Solutions

Li-min, Huang; Salvador‐Silva, Mercedes; Leang, Ronika S

doi:10.1097/icl.0000000000000338

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…Multipurpose solution manufacturers are faced with a challenge in designing a solution that is biocompatible with the ocular surface but is also capable of disinfecting, cleaning, improving wettability, and preventing contact lens surface deposits. 1 Manufacturers have made progress, but our study suggests that there are variances among new generations of multipurpose solutions, which may hold important implications for comfort and ocular-surface integrity in contact lens wearers.…”

Section: Discussionmentioning

confidence: 89%

“…Current multipurpose lens care solutions contain combinations of preservatives for disinfection, buffers to maintain pH, chelating agents to remove proteins, surfactants to remove lipid deposits, and wetting agents to improve comfort. 1 However, even with today's advances, the combination of these chemicals has been shown in vitro to induce corneal epithelial cytotoxicity, which leads to reduced cell viability, disrupted corneal epithelial tight junctions, and diminished defense against pathogens. [2][3][4][5] In vitro studies also suggest that multipurpose solution may affect tear-film stability by altering lens-surface properties, which may influence contact lens comfort and dryness.…”

mentioning

confidence: 99%

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Effects of Lens-Care Solutions on Hydrogel Lens Performance

Kitamata-Wong

Yuen

et al. 2017

Optom Vis Sci

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Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

Effects of Lens-Care Solutions on Hydrogel Lens Performance

Kitamata-Wong

Yuen

et al. 2017

Optom Vis Sci

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“…The three characteristic peaks at 37.5 • (411), 46.1 • (002), and 57.6 • (611) clearly represent the As 2 S 2 materials. Additionally, the peaks at 48.9 • and 59.9 • indicate the presence of As(OH) 3 inorganic material [22]. With the incorporation of these inorganic materials inside the polymer matrix, the shape of the peaks show loss of intensity from the coating with the organic material.…”

Section: Analysesmentioning

confidence: 99%

Quantum Dot Supernova-like-Shaped Arsenic (III) Sulfide-Oxide/Polypyrrole Thin Film for Optoelectronic Applications in a Wide Optical Range from Ultraviolet to Infrared

H. Alkallas,

M. Elsayed,

Ben Gouider Trabelsi

et al. 2023

Catalysts

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A quantum dot (QD) thin film of arsenic (III) oxide-hydroxide/polypyrrole (As2S3-As2O3/Ppy) with a supernova-like shape has been developed for optoelectronic applications across a wide optical range, spanning from ultraviolet (UV) to infrared (IR). The fabrication process involves the polymerization of pyrrole to form Ppy in the presence of NaAsO2 and K2S2O8. The resulting QD exhibits a remarkable morphology characterized by a supernova-like structure and a porous nature with a particle size of 4 nm. The unique morphology of the QD contributes to its optical properties. The material demonstrates a maximum optical absorbance that extends up to 600 nm. The chemical structure of the composite has been proved using various characterization techniques. The As2S3-As2O3/Ppy QD thin film holds significant potential for optoelectronic applications, particularly in light detection across multiple optical regions. Its sensitivity has been evaluated through the measurement of photoresponsivity (R), yielding a high value of 0.31 mA/W. This indicates a substantial current density (Jph) of 0.031 mA/cm2 at a wavelength of 340 nm. Additionally, the detectivity (D) of the photodetector has been calculated based on these values, resulting in a detection capability of 6.9 × 107 Jones. This indicates the ability to detect low levels of photons using this photodetector. The highly reproducible nature of this photodetector enables its application in various optoelectronic systems. The As2S3-As2O3/Ppy QD thin film offers great promise as a versatile optoelectronic application with its wide optical range, excellent sensitivity, and detectivity.

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In vitro tear replenishment system: assessing drug delivery from contact lens biomaterials through corneal epithelial monolayer and multilayer under replenishment conditions

Mohammadi,

Eslami,

Jones

et al. 2024

Drug Deliv. and Transl. Res.

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There is a need to develop improved in vitro ocular models for biocompatibility and drug delivery studies to assess the potential of in vivo performance of contact lenses. By using an in vitro corneal epithelial cell model combined with a tear replenishment method, this study aimed to investigate the delivery of the glaucoma drug latanoprost from contact lenses and compare the dynamic release results to no-replenishment (immersion) conditions. Corneal epithelial cells were grown as a monolayer or multilayer on curved cellulose cell culture inserts. Three contact lens materials (balafilcon A; senofilcon A; etafilcon A), soaked for 24 h in latanoprost, were placed on the curved cornea models (CCM) and drug concentration was determined on the basal (diffusion/transport) and apical (supernatant) sides after 1, 4, 8 and 12 h. The in vitro tear replenishment was achieved via intermittent flow of a tear solution over the CCM at a rate of 1 mL/hour. A zero-order kinetic was observed for basal drug concentration over the 12 h period. Similar basal and apical drug concentrations were observed with monolayer and multilayer CCM, except for the etafilcon A material. The apical release of latanoprost was significantly lower under replenishment compared to no-replenishment conditions. These results demonstrate the role that a dynamic release model will have in predicting the amount of drug that can be released from a contact lens into the tear film and the critical role of a cell monolayer in in vitro drug delivery studies. Graphical Abstract

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Correlations of In Vitro Assays for Assessing Cytotoxicity and Biocompatibility of Contact Lens Multipurpose Solutions

Cited by 7 publications

References 37 publications

Effects of Lens-Care Solutions on Hydrogel Lens Performance

Effects of Lens-Care Solutions on Hydrogel Lens Performance

Quantum Dot Supernova-like-Shaped Arsenic (III) Sulfide-Oxide/Polypyrrole Thin Film for Optoelectronic Applications in a Wide Optical Range from Ultraviolet to Infrared

In vitro tear replenishment system: assessing drug delivery from contact lens biomaterials through corneal epithelial monolayer and multilayer under replenishment conditions

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