Correlations of lean body mass with nutritional indicators and mortality in patients on peritoneal dialysis

Dong, Jie; Li, Y.-j.; Lu, Xin-Hong; Gan, Hong-bing; Zuo, Li; Wang, H.-y.

doi:10.1038/sj.ki.5002644

Cited by 41 publications

(32 citation statements)

References 24 publications

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“…Lean body mass by the creatinine kinetics method was used to determine muscle protein stores (12,13). A dynamometer was used to evaluate hand-grip strength in both the dominant and the nondominant arm; the measurement was repeated 3 times, and the highest value achieved was recorded in newtons.…”

Section: Diagnosis Of Peritonitismentioning

confidence: 99%

Clinical Characteristics and Outcomes of “Silent” and “Non-Silent” Peritonitis in Patients on Peritoneal Dialysis

Dong

Luo

et al. 2013

Perit Dial Int

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♦ Objectives: We compared the clinical characteristics and outcomes of "silent" peritonitis (meaning episodes without fever and abdominal pain) and "non-silent" peritonitis in patients on peritoneal dialysis (PD). ♦ Methods: Our cohort study collected data about all peritonitis episodes occurring between January 2008 and April 2010. Disease severity score, demographics, and biochemistry and nutrition data were recorded at baseline. Effluent cell counts were examined at regular intervals, and the organisms cultured were examined. Treatment failure was defined as peritonitis-associated death or transfer to hemodialysis. ♦ Results: Of 248 episodes of peritonitis occurring in 161 PD patients, 20.9% led to treatment failure. Of the 248 episodes, 51 (20.6%) were not accompanied by fever and abdominal pain. Patients with these silent peritonitis episodes tended to be older (p = 0.003). The baseline values for body mass index, triglycerides, and daily energy intake were significantly lower before silent peritonitis episodes than before non-silent episodes (p = 0.01, 0.003, and 0.001 respectively). Although silent peritonitis episodes were more often culture-negative and less often caused by gram-negative organisms, and although they presented with low effluent white cell counts on days 1 and 3, the risk for treatment failure in those episodes was not lower (adjusted odds ratio: 1.33; 95% confidence interval: 0.75 to 2.36; p = 0.33). ♦ Conclusions: Silent peritonitis is not a rare phenomenon, especially in older patients on PD. Although these episodes were more often culture-negative, silent presentation was not associated with a better outcome.Perit Dial Int 2013; 33(1):28-37 www.PDIConnect.com epub ahead of print:

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Section: Diagnosis Of Peritonitismentioning

confidence: 99%

Clinical Characteristics and Outcomes of “Silent” and “Non-Silent” Peritonitis in Patients on Peritoneal Dialysis

Dong

Luo

et al. 2013

Perit Dial Int

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“…Weekly total, peritoneal, and renal Kt/V urea; weekly total, peritoneal, and renal creatinine clearance; and residual renal function were calculated using standard methods. Lean body mass (LBM) by creatinine kinetics method was used to reflect muscle protein stores (24,25) and also normalized by the square of height. Total sodium removal was the sum of urinary and dialysate sodium removal (26).…”

Section: Biochemical Dialysis Adequacy and Nutrition Variablesmentioning

confidence: 99%

Low Dietary Sodium Intake Increases the Death Risk in Peritoneal Dialysis

Dong

Yang

et al. 2010

Clinical Journal of the American Society of Nephrology

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Background and objectives: To explore the correlation between dietary sodium intake and cardiovascular and overall mortality, and then determine whether this correlation can be explained by protein and energy intake paralleled with sodium intake in dialysis patients.Design, setting, participants, & measurements: This single-center retrospective cohort study enrolled 305 incident patients who started peritoneal dialysis in our unit from July 2002 to February 2007. All patients were followed until death or until being censored in February 2008. Demographic data were collected at baseline. Biochemical, dietary, and nutrition data were examined at baseline and thereafter at regular intervals to calculate the average values throughout the study.Results: Participants with the highest average sodium intake were more likely to be younger, male, and overweight. Patients in the high tertile of average sodium intake had higher albumin, prealbumin, and lean body mass levels, and more nutrient intakes paralleling with sodium intake. Low average sodium intake independently predicted the increased risk for overall and cardiovascular death after adjusting for recognized confounders. Further adjustment for dietary protein, energy, and other nutrient intakes individually had minimal impact on the association between average sodium intake and overall death, with hazard ratios varying between 0.35 and 0.44, and cardiovascular death, with hazard ratios varying between 0.06 and 0.11.Conclusions: This study revealed that low dietary sodium intake independently predicts the high overall and cardiovascular mortality in dialysis patients. This correlation could not be entirely explained by deficient protein and energy intake.

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“…Since recent investigations have documented a powerful association between muscle wasting and mortality in patients with CKD [7][8][9] , AMA might be an important predictor of the prognosis of hemodialysis patients. A decrease in the AMA of hemodialysis patients, compared with that in normal controls, has been reported [10,11] .…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Body Composition and Nutritional Status in Patients Receiving Hemodialysis Therapy for More than 30 Years

Ishihara

Otsubo²,

Naoki

et al. 2010

Blood Purif

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Background/Aims: We investigated the body composition and nutritional status of extremely long-term (more than 30 years) hemodialysis patients. Methods: Eighty outpatients receiving maintenance hemodialysis (including 18 for more than 30 years) were enrolled. We classified the patients according to the duration of hemodialysis therapy (less than 10 years, 10–20 years, 20–30 years, or over 30 years) and compared the laboratory and anthropometric data. Results: No significant differences in age or the total protein, albumin, total cholesterol, triglyceride or CRP levels were observed. The corrected body mass index (BMI) was significantly lower in the more than 30 years than in the less than 10 years group. The corrected arm muscle area (AMA) was significantly lower in the more than 30 years group than in the other groups. Conclusion: In extremely long-term hemodialysis outpatients, the BMI and AMA were reduced, whereas nutritional markers were relatively preserved.

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Correlations of lean body mass with nutritional indicators and mortality in patients on peritoneal dialysis

Cited by 41 publications

References 24 publications

Clinical Characteristics and Outcomes of “Silent” and “Non-Silent” Peritonitis in Patients on Peritoneal Dialysis

Clinical Characteristics and Outcomes of “Silent” and “Non-Silent” Peritonitis in Patients on Peritoneal Dialysis

Low Dietary Sodium Intake Increases the Death Risk in Peritoneal Dialysis

Characteristics of Body Composition and Nutritional Status in Patients Receiving Hemodialysis Therapy for More than 30 Years

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