Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome

Zhang, Jinjin; Wu, Xianhao; Gao, Peizhen; Yan, Peng

doi:10.1186/s12872-017-0483-8

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…Unlike SCr, urinary IgG, or transferrin, Cys-C is not influenced by gender, race, and muscle mass, and thus has recently drawn considerable attention (Peralta et al, 2011). Cys-C also exhibits predictive value for the prognosis of renal and cardiovascular diseases (Peralta et al, 2011;Ozkok et al, 2014;Barr et al, 2017;Zhang et al, 2017). In our study, we found that STS plus ARBs therapy was better than ARBs alone in improving urinary protein, SCr, and eGFR, which also suggested that STS could be beneficial as an "add-on" medication for hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Zhang

Shi

et al. 2019

Front. Pharmacol.

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Background: Sodium tanshinone IIA sulfonate (STS) injection, the extractive of traditional Chinese medicine Danshen, is supposed to be a supplementary treatment in hypertensive nephropathy. Objectives: To evaluate the efficacy and safety of STS in treatment of hypertensive nephropathy. Methods: We systematically searched China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wan-fang database, Chinese Biomedicine Database (CBM), PubMed, Embase, Web of Science, and Cochrane Library from their inception to December 2018. All studies were screened by two reviewers according to the inclusion and exclusion criteria independently. The Cochrane Collaboration's risk tool was used to assess the methodological quality of the included studies. Reviewer Manager 5.3 was employed for statistical analysis. Results: Sixteen trials involving 1,696 patients were included. The meta-analysis results indicated a combination of STS and angiotensin receptor blockers (ARBs) was more effective than ARB monotherapy in modulating hypertensive nephropathy, as represented by improved estimated glomerular filtration rate (eGFR) [mean difference (MD) = 6.87, 95% CI (4.47, 9.28), P < 0.00001] and reduced 24 h urinary protein [MD = −0.23, 95% CI (−0.27, −0.19), P < 0.00001], serum creatinine (SCr) [MD = −21.74, 95% CI (−24.11, −19.38), P < 0.00001], cystatin-C [MD = −0.16, 95% CI (−0.24, −0.07), P = 0.0003], urinary immunoglobulin G (IgG) [MD = −0.85, 95% CI (−1.11, −0.59), P < 0.00001], and urinary transferrin [MD = −0.61, 95% CI (−1.04, −0.17), P = 0.007]. In addition, the combination therapy had better control in systolic blood pressure (SBP) [MD = −6.53, 95% CI (−8.19, −4.87), P < 0.00001] and diastolic blood pressure (DBP) [MD = −4.14, 95% CI (−5.69, −2.59), P < 0.00001]. Only three trials reported adverse events, and no adverse drug reactions were observed.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Zhang

Shi

et al. 2019

Front. Pharmacol.

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“…Pascual et al suggested that cystatin C independently predicts death or heart failure rehospitalization with greater accuracy than creatinine [ 22 ]. Various studies found that cystatin C is also an important prognostic factor of a poor outcome in patients with acute coronary syndrome [ 23 , 24 ]. These all demonstrated the prognostic significance of cystatin C in cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Association of serum cystatin C levels with mortality in patients with acute type A aortic dissection

Feng

Zhou

et al. 2017

Oncotarget

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“…The concentration of serum Cys C was measured using a kit provided by Kyokuto Pharmaceutical Industrial (Tokyo, Japan), and the level is expressed in units of mg/dL. 13 The reference value of Cys C is ≤1.0 mg/L. In all patients, the serum Cys C concentration was measured within 24 h after admission.…”

Section: Methodsmentioning

confidence: 99%

Association of serum cystatin C levels with acute coronary syndrome in patients of advanced age

Huang

Shen

et al. 2019

J Int Med Res

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Objective This study was performed to investigate the relationship between the serum cystatin C (Cys C) level and acute coronary syndrome (ACS) in patients of advanced age. Methods The study included 184 patients with ACS and 46 healthy control subjects. Statistical analysis was performed using SPSS version 14.0 (SPSS Inc., Chicago, IL, USA). Results The serum Cys C level was significantly higher in patients with than without ACS (1.24 ± 0.30 vs. 1.42 ± 0.46 mg/L, respectively). Patients with more stenotic coronary arteries were significantly more likely to have higher median serum Cys C and creatinine levels and a lower estimated glomerular filtration rate. The multivariate logistic regression analysis demonstrated that the serum Cys C level was independently associated with the presence of ACS and the quantity of stenotic coronary arteries after adjustment for confounding factors. Additionally, the serum Cys C level was positively correlated with age, the creatinine level, and the N-terminal pro-B-type natriuretic peptide level in all patients but was negatively correlated with the estimated glomerular filtration rate. Conclusion A high serum Cys C level was independently associated with ACS and the quantity of stenotic coronary arteries in patients of advanced age regardless of renal function.

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Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome

Cited by 10 publications

References 26 publications

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Association of serum cystatin C levels with mortality in patients with acute type A aortic dissection

Association of serum cystatin C levels with acute coronary syndrome in patients of advanced age

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