Correlative circadian rhythms of cholecystokinin and dopamine content in nucleus accumbens and striatum of rat brain

Schade, Rüdiger; Vick, K.; Sohr, R.; Ott, Tilmann; Pfister, C; Bellach, J.; Mattes, Andreas; Lemmer, Björn

doi:10.1016/0166-4328(93)90168-p

Cited by 25 publications

(18 citation statements)

References 17 publications

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“…The peak of DOPAC, delayed by 2 h with respect to the nadir of DA, reflects the deamination rate of DA. These data support previous studies showing circadian changes of catecholamine levels in some regions of rat brain [5, 6, 7, 9, 31, 32, 33], and show that pinealectomy and aMT replacement therapy influence the dopaminergic but not serotonergic system in the striatum. Although some reports point to an involvement of aMT in the 5-HT turnover in some brain areas in rats [34], the lack of interaction between aMT and 5-HT in the mouse striatum agrees with other studies [35].…”

Section: Discussionsupporting

confidence: 92%

“…In the rat striatum, circadian fluctuations in the content [5], the turnover [6]and the release [7]of DA were reported, resulting in functional changes in dopaminergic synapse activity leading to rhythmic behavioral events [8 , 9]. …”

Section: Introductionmentioning

confidence: 99%

“…Circadian rhythms of brain GABA and benzodiazepine receptors are driven by the pineal gland through the circadian release of aMT [13, 14]. Rhythmic production of DA was also shown in the rat striatum [5], although no study relating this rhythm to that of aMT is available as yet. Interaction between DA and aMT has been reported however in several brain areas [15, 16].…”

Section: Introductionmentioning

confidence: 99%

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Circadian Rhythms of Dopamine and Dihydroxyphenyl Acetic Acid in the Mouse Striatum: Effects of Pinealectomy and of Melatonin Treatment

et al. 2002

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The existence of dopamine (DA)-melatonin (aMT) relationships is well documented in several brain areas of the mammalian central nervous system such as the retina and hypothalamus or the nigrostriatal system. For instance, aMT tempers 1 methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigrostriatal damage in C57BL/6 mice. In this mouse strain however, rhythmic production of aMT and its possible interaction with striatal DA is still unclear. In the present work we investigated circadian variations in pineal production of aMT and striatal DA levels in C57BL/6 mice. Effects of pinealectomy and aMT administration were also assessed. Intact, pinealectomized and pinealectomized + aMT-treated mice and their respective control groups were sacrificed at six different times during the 24-hour period. In control animals, aMT displayed a circadian rhythm with a narrow peak at midnight. The peak of aMT coincided with the nadir of the DA rhythm present in the striatum. Shortly after the decrease of DA levels, an increase in 3,4-dihydroxyphenylacetic acid (DOPAC), the main DA metabolite, was observed. The rhythmic changes of DA and DOPAC levels in the striatum were blunted by pinealectomy, whereas administration of aMT (0.1–10 mg/kg) during 6 days to pinealectomized mice restored the rhythms in a dose-dependent manner. Striatal levels of 3-methoxytyramine and homovanillic acid did not change during the 24-hour cycle. The serotonergic system, assessed by the determination of 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid concentration in striatum, did not show significant time-dependent changes in control animals and was not affected by pinealectomy or aMT treatment. These data substantiate the existence of a link between pineal function, melatonin secretion and DA circadian rhythm in the mouse striatum.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circadian Rhythms of Dopamine and Dihydroxyphenyl Acetic Acid in the Mouse Striatum: Effects of Pinealectomy and of Melatonin Treatment

et al. 2002

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“…PLMS is currently understood as a disorder of dopaminergic dysfunction, due to the dramatic reductions in these movements with dopaminergic precursors or agonists [28,29], the worsening of PLMs with dopaminergic antagonists [30,31], and the presence of PLMs in disorders associated with hypodopaminergic function [32]. There are reports from animal studies that dopamine receptor binding (33;34) and dopamine content [35,36] in various brain regions show a bimodal pattern, with peaks approximately midway through both the light and dark phases. In humans, the dopaminergic metabolite homovannillic acid in plasma (pHVA) has become a standard measure to assess dopamine levels in the CNS [37–39].…”

Section: Discussionmentioning

confidence: 99%

Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night

et al. 2011

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Objective Periodic limb movements in sleep (PLMS) show a time-of-night pattern, with most movements at the beginning of the night. Our study aimed to determine whether this pattern is due to an endogenous circadian rhythm, like that in the related movement disorder Restless Legs Syndrome (RLS). Methods Four healthy older adults with a screening PLMI> 20 were studied in an inpatient forced desynchrony protocol with an imposed sleep-wake cycle of 20 hours for twelve “nights,” allowing separation of circadian and sleep homeostatic influences on leg movements. We recorded sleep polysomnographically throughout each scheduled episode, including left and right anterior tibialis EMG. Results PLMS in Stage 2 showed both a significant time-within-sleep pattern and a significant circadian rhythm. The circadian rhythm in PLMS peaked at the circadian phases when usual sleep onset occurs, preceding the evening rise in melatonin secretion. Conclusions In our subjects, the circadian pattern of PLMs expression was very similar to that previously reported in patients with RLS. This evidence for a circadian rhythm in PLMS has implications for treatment and provides direction for future studies of the pathophysiology of this movement disorder.

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“…Tissue samples were punched out (1 mm in diameter) according to Paxinos and Watson (1986) using a cryo-microtom. CCK determination was performed by use of a RIA, DA was determinated by electrochemical detection after HPLC-separation (Schade et al, 1993). Complex circadian rhythms were found for both CCK and DA.…”

Section: Introductionmentioning

confidence: 99%

Blood, transmitters and neuropeptides

Schade

Vick

Sohr

et al. 1993

Journal of Interdisciplinary Cycle Research

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Correlative circadian rhythms of cholecystokinin and dopamine content in nucleus accumbens and striatum of rat brain

Cited by 25 publications

References 17 publications

Circadian Rhythms of Dopamine and Dihydroxyphenyl Acetic Acid in the Mouse Striatum: Effects of Pinealectomy and of Melatonin Treatment

Circadian Rhythms of Dopamine and Dihydroxyphenyl Acetic Acid in the Mouse Striatum: Effects of Pinealectomy and of Melatonin Treatment

Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night

Blood, transmitters and neuropeptides

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