Corrigendum Cohort Profile: The ENVIRonmental influence ON early AGEing (ENVIRONAGE): a birth cohort study

Janssen, Bram G.; Madhloum, Narjes; Gyselaers, Wilfried; Bijnens, Esmée; Clemente, Diana B.P.; Cox, Bianca; Roels, Harry; Winckelmans, Ellen; Vrijens, Karen; Nawrot, Tim S.

doi:10.1093/ije/dyx033

Cited by 80 publications

(77 citation statements)

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“…Our participation rate was just under 50%, which might result in a not completely representative sample of the target population (e.g. low maternal occupation was 18% in our study population while we expected 26% 49 ). However, we do not expect this to have an impact on the mechanistic associations reported in this study.…”

Section: Discussionmentioning

confidence: 94%

Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children

Provost

Panis

Saenen

et al. 2017

Environmental Research

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Section: Discussionmentioning

confidence: 94%

Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children

Provost

Panis

Saenen

et al. 2017

Environmental Research

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“…One of our major strengths is that we were able obtain a wide panel of cardiovascular measurements in 4-to-5-year-olds using a standardized protocol and multiple measurements (five blood pressure assessments, CIMT determined at three different angels and retinal microvascular measures from both eyes). The ENVIRONAGE study is a prospective birth cohort and is transferable to the general population as our study population is at baseline representative of the gestational segment of the population at large 8,50 and at the age of 4 because of the high participation rate (57%) towards follow-up. As with all longitudinal studies we were not able to contact a part of the initial cohort (n = 98), however results are unlikely to be confounded by selection bias; participants and non-participants had similar sociodemographic characteristics such as sex, age, and maternal education.…”

Section: Discussionmentioning

confidence: 99%

“…The data were obtained from the follow-up study of the ENVIRONAGE (ENVIRonmental influence ON early AGEing) birth cohort. This longitudinal cohort has been described in more detail previously 8 . In brief, ENVIRONAGE is a population-based prospective birth cohort study located in Limburg, Belgium.…”

Section: Methodsmentioning

confidence: 99%

Establishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort

Madhloum

Luyten

Provost

et al. 2020

Sci Rep

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Cardiovascular risk factors are usually better tolerated, and can therefore be perceived as less harmful, at a young age. However, over time the effects of these adverse factors may persist or accumulate and lead to excess morbidity and mortality from cardiovascular diseases later in life. Until now, reference values for the basic cardiovascular health characteristics of 4-to-6 year-old children are lacking. Within a follow-up study of the ENVIRONAGE (ENVIRonmental influence ON early AGE) birth cohort we assessed various cardiovascular measurements in 288 children aged 4-5 years. For the macrovasculature, we measured their blood pressure and examined the intima-media thickness of the carotid artery (CIMT), the arterial elasticity (including the pulse-wave velocity (PWV), carotid distensibility (DC) and compliance (CC) coefficients), the carotid β stiffness index (SIβ) and Young's Elastic Modulus (YEM). Retinal microvascular traits included the Central Retinal Arteriolar Equivalent (CRAE) and Central Retinal Venular Equivalent (CRVE). Age of the study population averaged (±SD) 4.2 (±0.4 years. Mean systolic and diastolic blood pressure were 97.9 (±8.1) mmHg and 54.7(±7.6) mmHg, respectively. CIMT for the total population averaged 487.1 (±68.1) µm. The average stiffness values for DC, CC, SIβ, and PWV were 78.7 (±34.2) 10 − ³/kPa, 1.61 (±0.59) mm 2 /kPa and 4.4 (±2.4), and 3.7 m/s (±0.9) respectively. The mean determined for YEM was 163.2 kPa (±79.9). Concerning the microvasculature, the average CRAE was 180.9 (±14.2) µm and the corresponding value for CRVE was 251.0 (±19.7) µm. in contrast to the macrovasculature, a significant gender-related difference existed for the microvasculature: in boys, both the CRAE (178.8 µm vs 182.6 µm; p = 0.03) and CRVE (247.9 µm vs 254.0 µm; p = 0.01) were narrower than in girls. We have provided reference values for young children to understand changes in the early cardiovascular health trajectory. Establishing these reference values of cardiovascular phenotypes at this young age is necessary to develop targeted health promotion strategies as well as for better understanding of the life course changes of both small and large blood vessels. Risk factors for the development of cardiovascular diseases, such as smoking, an inactive lifestyle, and high blood pressure are usually better tolerated at a younger age and are therefore often perceived as less harmful within this phase in life. However, if these physical challenges persist over time, they may lead to an increase in morbidity and mortality from cardiovascular causes in midlife. In adults, several clinical parameters have been linked to cardiovascular disease trajectories. For example, the distance between the intima and media layer of the carotid vessel wall is commonly used as an indicator of the extent of atherosclerosis and the chance of developing cerebral and cardiovascular incidences 1. For adults at risk of diseases of the heart and the circulatory system, guidelines for

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“…Our findings are generalizable as our study population is representative for the gestational segment of the population at large. 7 Another advantage of our study was the use of acrylamide biomarkers. Biomarkers should not be assumed to always be superior to other methods of acrylamide exposure assessment, such as food frequency questionnaires, because a biomarker may not represent the exposure during the relevant period for disease etiology well, e.g., due to intra-individual variations of exposure in time.…”

Section: Discussionmentioning

confidence: 99%

“…Further details of the study are reported elsewhere. 7 The analysis described in this paper involved 443 mother-child pairs for which we had acrylamide to hemoglobin adduct measurements in umbilical cord blood and complete covariable data.…”

Section: Study Population and Data Collectionmentioning

confidence: 99%

Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

Hogervorst

Vesper²,

Madhloum

et al. 2019

Preprint

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Background Up to now, 3 epidemiological studies have shown clear inverse associations between prenatal acrylamide exposure and birth size. In addition to studying the association between acrylamide and birth size, we investigated the interaction between acrylamide and polymorphisms in acrylamide-metabolising genes, with the aim of probing the causality of the inverse relationship between acrylamide and fetal growth. Methods We investigated the association between prenatal acrylamide exposure (acrylamide and glycidamide to hemoglobin adduct levels (AA-Hb and GA-Hb) in cord blood) and birth weight, length and head circumference in 443 newborns of the ENVIRONAGE (ENVIRonmental influence ON AGEing in early life) birth cohort. In addition, we studied interaction with single nucleotide polymorphism (SNPs) in CYP2E1, EPHX1 and GSTP1, using multiple linear regression analysis. Results Compared to neonates in the lowest quartile of AA-Hb in cord blood, the body weight, length and head circumference of neonates in the highest quartile were -101 grams (95% CI: -208, 7; p for trend = 0.12), -0.13 centimetres (95% CI: -0.62, 0.36; p for trend = 0.69) and -0.41 centimetres (-0.80, -0.01; p for trend = 0.06) lower, respectively. For GA-Hb, the corresponding effect estimates were -222 grams (95% CI: -337, -108; p for trend = 0.001), -0.85 (95% CI: -1.38, -0.33; p for trend = 0.02) and -0.55 (95% CI: -0.98, -0.11; p for trend = 0.01), respectively. The associations for GA-Hb were similar or stronger in newborns of non-smoking mothers. There was no statistically significant interaction between acrylamide exposure and the studied genetic variations but there was a trend of stronger inverse associations with birth weight and head circumference among newborns with homozygous wildtypes alleles for the CYP2E1 SNPS and with variant alleles for a GSTP1 SNP (rs1138272). Conclusions Prenatal dietary acrylamide exposure, specifically in the form of its metabolite glycidamide, was inversely associated with birth weight, length and head circumference. The interaction pattern with SNPs in CYP2E1, although not statistically significant, is an indication for the causality of this association. Other studies are needed to corroborate this finding.

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Corrigendum Cohort Profile: The ENVIRonmental influence ON early AGEing (ENVIRONAGE): a birth cohort study

Cited by 80 publications

References 0 publications

Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children

Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children

Establishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort

Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

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