Corrigendum to “A live attenuated strain of Yersinia pestis as a vaccine against plague” [Vaccine 29 (2011) 2986–2998]

Sun, Wei; Six, David A.; Kuang, Xiaoying; Roland, Kenneth L.; Raetz, Christian R. H.; Curtiss, Roy

doi:10.1016/j.vaccine.2011.06.021

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings provide a good illustration of the fact that the active (endotoxic) LPS form also plays a positive role in a host, ensuring prompt pathogen recognition and activation of the innate immune system at the early stages of infection. It has been demonstrated on mice model that attenuated Y. pestis strains with the immunostimulating LPS form can be regarded as a prototype for a new, efficient live vaccine against plague [ 27 , 53 ].…”

Section: Biological Properties and Role In Plague Pathogenesismentioning

confidence: 99%

Lipopolysaccharide of Yersinia Pestis, the Cause of Plague: Structure, Genetics, Biological Properties

Knirel

Anisimov

2012

Acta Naturae

View full text Add to dashboard Cite

The present review summarizes data pertaining to the composition and structure of the carbohydrate moiety (core oligosaccharide) and lipid component (lipid A) of the various forms of lipopolysaccharide (LPS), one of the major pathogenicity factors ofYersinia pestis, the cause of plague. The review addresses the functions and the biological significance of genes for the biosynthesis of LPS, as well as the biological properties of LPS in strains from various intraspecies groups ofY. pestis and their mutants, including the contribution of LPS to the resistance of bacteria to factors of the innate immunity of both insect-vectors and mammal-hosts. Special attention is paid to temperature-dependent variations in the LPS structure, their genetic control and roles in the pathogenesis of plague. The evolutionary aspect is considered based on a comparison of the structure and genetics of the LPS ofY. pestis and other enteric bacteria, including otherYersinia species. The prospects of development of live plague vaccines created on the basis ofY. pestis strains with the genetically modified LPS are discussed.

show abstract

Section: Biological Properties and Role In Plague Pathogenesismentioning

confidence: 99%