Corrigendum to “Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT” [Int J Reprod BioMed 2016; 14: 341-346]

Eftekhar, Maryam; Hosseinisadat, Robabe; Baradaran, Ramesh; Naghshineh, Elham

doi:10.18502/ijrm.v20i1.10411

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“…In a study conducted by Eftekhar and colleagues, they investigated cases of recurrent implantation failure despite normal endometrial thickness and found that intra-uterine infusion of G-CSF did not increase endometrial thickness or significantly improve pregnancy rates [18].…”

Section: Discussionmentioning

confidence: 99%

Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

elmohamady¹,

Salama²,

Okasha³

2024

Ital J Gynaecol Obstet

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Objective. We studied the G-CSF's effect on women with unexplained infertility and previous ICSI failure. Unexplained infertility is a condition when couples are not able to conceive despite normal semen analysis and absence of female infertility factor(s). Cytokines, transcription factors and signaling pathways are essential for complex interactions of decidualization. G-CSF is a glycoprotein with growth factor and cytokine functions, which are produced in many tissues.Patient and Methods. The study was done on a total of 200 women with only 196 women who ended the study (99 women as a study group, 96 women as a control group). All women were M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n complaining of unexplained infertility with previous history of failed ICSI. All cases proceed through ICSI procedure while study group only undergone G-CSF infusion intrauterine at time of ovum pickup.Results. We found that intrauterine G-CSF injection at time of ovum pickup in the study group, in comparison with control group, did not improve neither implantation rate (16.68% vs 19.66%, p = 0.243) nor the chemical (54.5% vs 67%, p = 0.074), clinical pregnancy (51.5% vs 62.9%, p = 0.108) rates as well as live birth rates (31.0% vs 39.8%, p = 0.227). Conclusions.Intrauterine infusion of G-CSF may not improve Implantation rate in women with unexplained previous intracytoplasmic sperm injection (ICSI) failure. Further studies are needed to conclude if the dose, route and timing of the drug administration can give better results.

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Section: Discussionmentioning

confidence: 99%

Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

elmohamady¹,

Salama²,

Okasha³

2024

Ital J Gynaecol Obstet

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Corrigendum to “Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT” [Int J Reprod BioMed 2016; 14: 341-346]

Abstract: This is a Corrigendum to “Effect of granulocyte colony stimulating factor (G-CSF) on IVF outcomes in infertile women: An RCT” [Int J Reprod BioMed 2016; 14: 341-346] and does not have an abstract. Please download the PDF or view the article HTML.

Cited by 1 publication

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Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

Impact of granulocyte colony stimulating factor infusion on the implantation rate in women with unexplained previous intracytoplasmic sperm injection failure: a case control study

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