Corrigendum to “miR-1-Mediated Induction of Cardiogenesis in Mesenchymal Stem Cells via Downregulation of Hes-1”

Huang, Feng; Tang, Liang; Fang, Zhenfei; Hu, Xinqun; Pan, Jiayi; Zhou, Shenghua

doi:10.1155/2016/8510747

Cited by 2 publications

(4 citation statements)

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“…The Wnt signaling pathway also simultaneously regulates the proliferation and the differentiation of BMSCs [ 24 ]. Moreover, miRNA could regulate gene expression and act as important factors in the cardiomyocytes development and the differentiation of stem cell [ 12 – 14 ].Therefore, these observations raised an interesting question whether miRNA could modulate signaling pathway to regulate the differentiation of stem cell. Recently, accumulated evidences indicated that miRNA could regulate various bioprocesses by targeting Wnt signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

“…While, Huang F et al found there was only downregulation of Hes-1,the downstream target molecule of the Notch pathway, but not regulation upstream molecules of the Notch pathway [14]. Because Notch signaling is initiated via ligand-Notch receptor interactions on neighboring cells [15].…”

Section: Introductionmentioning

confidence: 99%

“…The miR1 has been reported to be able to modulate cardiomyogenesis and maintain the expression of muscle genes via down regulating the Notch or STAT3 signaling pathways [ 12 – 14 ]. While, Huang F et al found there was only downregulation of Hes-1,the downstream target molecule of the Notch pathway, but not regulation upstream molecules of the Notch pathway [ 14 ]. Because Notch signaling is initiated via ligand-Notch receptor interactions on neighboring cells [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

et al. 2017

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BackgroundBone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed to investigate the role of miR1-2 in differentiation of mouse BMSCs into cardiomyocyte-like cells and reveal the involved signaling pathways in the procedure.MethodsMouse BMSCs were treated with miR1-2 and 5-azacytine (5-aza). The expression of cardiac cell markers: NKx2.5, cTnI and GATA4 in BMSCs were examined by qPCR. The apoptosis rate was detected by flow cytometry and the activity of the Wnt/β-catenin signaling pathway was evaluated by measuring the upstream protein of this signaling pathway.ResultsAfter over-expression of miR1-2 in mouse BMSCs, the apoptosis rate was significantly lower than the 5-aza group, while the expressions of cardiac-specific genes: such as Nkx2.5, cTnI and GATA4 were significantly increased compared to the control group and the 5-aza group. Meanwhile, over-expression of miR1-2 in mouse BMSCs enhanced the expression of wnt11, JNK, β-catenin and TCF in the Wnt/β-catenin signaling pathway. Use of LGK-974, an inhibitor of Wnt/β-catenin signaling pathway, significantly reduced the expression of cardiac-specific genes and partially blocked the role of the miR1-2.ConclusionOver-expression of miR1-2 in mouse BMSCs can induce them toward promoted cardiomyocyte differentiation via the activation of the Wnt/β-catenin signaling pathway. Compared to 5-aza, miR1-2 can induce differentiation of BMSCs into cardiomyocytes more effectively with a less cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

et al. 2017

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“…miRNAs could regulate gene expression and the cardiomyocyte development and differentiation of stem cells [ 26 ], including BMSCs. For instance, miR-23b inhibits the osteogenic differentiation of BMSCs via targeting Runx2 during treatment with TNF-α [ 27 ].…”

Section: Micrornasmentioning

confidence: 99%

Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

Guo

Zhang

et al. 2018

Stem Cell Res Ther

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In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells. Current research indicates that chemical substances, microRNAs, and cytokines have biological functions that regulate the cardiomyocytes differentiation of BMSCs. In this review, we chiefly summarize the regulatory factors that induce BMSCs to differentiate into cardiomyocytes.

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Corrigendum to “miR-1-Mediated Induction of Cardiogenesis in Mesenchymal Stem Cells via Downregulation of Hes-1”

Cited by 2 publications

References 1 publication

Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

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