Corrigendum to “WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice”

Kim, Ju Eun; Shrestha, Abinash Chandra; Kim, Hyo Shin; Ham, Ha Neul; Kim, Yeong Jee; Noh, Yun Jeong; Kim, Su Jin; Kim, Dae Keun; Jo, Hyung Kwon; Kim, Dae Sung; Hyun, Moon Kwang; Lee, Jehee; Jeong, Kyung Ok; Leem, Jae Yoon

doi:10.1155/2021/5127585

Cited by 3 publications

(3 citation statements)

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“…However, Chaenomeles sinensis extract has been utilized in tranditional medicine, and a number of preclinical studies have been recently performed to evaluate the in-depth pharmacological effects of Chaenomeles sinensis extract. For example, Kim and colleagues showed that WS-5, a 45% ethanol extract of a mixture of three traditional plants with Curcuma longa L. (turmeric), the fruits of Chaenomeles sinensis , and the dried rhizome of Zingiber officinale Roscoe (ginger) improved β-amyloid-induced memory impairment by inhibiting acetylcholine esterase (AChE) [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Kang

Zhao

Lee³

et al. 2022

J Cancer Prev

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Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the ethanol extract of Chaenomeles sinensis scavenged 2,2’-diphenylpicrylhydrazyl and 2,2’-azinobis diammonium radicals in vitro. The ethanol extract of Chaenomeles sinensis activated antioxidant response element-luciferase activity and induced expression of NRF2 target genes in HaCaT cells. The ethanol extract of Chaenomeles sinensis also suppressed LPS-induced expression of COX-2 and iNOS proteins, and mRNA expression of TNF-α and IL-2 in RAW264.7 cells. Finally, the ethanol extract of Chaenomeles sinensis significantly suppressed testosterone propionate-induced benign prostatic hyperplasia in mice. Together, our study provides the evidence that the ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Kang

Zhao

Lee³

et al. 2022

J Cancer Prev

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“…They improve cognitive performance by promoting the growth of neuronal synapses and modulating excitatory glutamatergic neurons [3,4]. Moreover, 6-gingerol and 6-shogaol in Ginger improve cognitive function by inhibiting neuroglial cell activation and reducing acetylcholinesterase expression levels [5,6]. Flavonoids (including naringenin, hesperidin, and naringin) in Tangerine are key components of their antioxidant activities, which may help restore nicotinamide adenine dinucleotide (NAD + ) levels and improve mitochondrial function [7,8].…”

Section: Introductionmentioning

confidence: 99%

Analysis of cerebrospinal fluid metabolites affected by WenDanTang based on ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry

Zou,

Tang,

et al. 2024

J of Separation Science

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WenDanTang (WDT) is a Chinese herbal formula used to treat various diseases, including neurodegenerative diseases. However, the neuroprotective metabolic pathways and the components involved in this process are not fully understood. In this study, we examined the neuroprotective metabolic pathways of WDT in rat brains using cerebrospinal fluid metabolomics and ultra‐high‐performance liquid chromatography–high‐resolution mass spectrometry. Twelve rats were randomly divided into a WDT (administrated with WDT solution) and a control group. The ultra‐high‐performance liquid chromatography technique was used to explore the components of the WDT solution and cerebrospinal fluid, and secondary mass spectra of cerebrospinal fluid were used to identify possible brain‐incorporating components after WDT. The results of the differential metabolism analysis showed that eight metabolites were typically altered (all p < 0.05). By comparing the secondary mass spectra of the cerebrospinal fluid of rats and WDT solution, two possible brain‐incorporating components of WDT, stachydrine and α‐methoxyphenylacetic acid, were identified. The data also suggested that WDT affects nucleotide metabolism, glutathione metabolism, and B‐vitamin metabolic pathways, the central differential metabolic pathways. These data suggest that WDT protects neurons through its active components, such as stachydrine, and regulates biochemical metabolism to affect the brain's energy metabolism and antioxidant capacity.

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“…Ginger (Zingiber officinale) belongs to the Zingiberaceae family, first used in India and China as a traditional medicine more than a thousand years ago, and is still predominantly consumed in South Asian countries. Ginger extract has many remedial impacts, such as antioxidant, anti-inflammatory, anticancer, antidiabetic, antineuroinflammatory, and antispasmodic effects . Due to the structural flexibility, nature has uniquely made gingerol with a methoxy group at position 4 of the phenyl ring and a 5-hydroxydecan-3-one backbone, with a 4-hydroxy-3-methoxyphenyl moiety at the first position .…”

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confidence: 99%

Tailoring the Molecular Structure of 6-Gingerol for Targeting the Phase Separation in Human Lysozyme

Bonda,

Mishra,

Bhatia

et al. 2024

J. Phys. Chem. Lett.

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Human lysozyme undergoes a phase-separation process to form insoluble amyloid-architects that cause several pathologies including systemic amyloidosis. Here we have tailored 6gingerol by extending its molecular framework with active functional groups to specifically target lysozyme phase-transition events. Aggregation assay revealed that tailored 6-gingerol with 4-aromatic moieties (MTV4) substantially suppressed the conversion of the lysozyme low-density liquid phase (LDLP) to solid-phase structured amyloids. The data obtained from biophysical, computational, and microscopic imaging tools suggest direct intervention of MTV4 with the liquid−liquid phase separation. The CD data suggest that MTV4 was able to retain the native conformation of lysozyme. Both biomolecular and computational data reveal the interference of MTV4 with the aggregation-prone hydrophobic stretches within the lysozyme, thereby retaining the native structure and reversing the misfolded intermediates to active monomers. Also, MTV4 was able to induce rapid dissolution of preformed-toxic amyloid fibrils. These results reinforce the importance of the aromatic−aromatic interaction in preventing human lysozyme phase separation.

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Corrigendum to “WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice”

Cited by 3 publications

References 1 publication

Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects

Analysis of cerebrospinal fluid metabolites affected by WenDanTang based on ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry

Tailoring the Molecular Structure of 6-Gingerol for Targeting the Phase Separation in Human Lysozyme

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