Corrosion and degradation decelerating alendronate embedded zinc phosphate hybrid coating on biodegradable Zn biomaterials

Mo, Xiaoshan; Qian, Junyu; Chen, Yingqi; Zhang, Wentai; Peng, Xian; Tang, Shuai; Zhou, Chao; Huang, Nan; Ji, Hua; Luo, En; Zhang, Haijun; Wan, Guojiang

doi:10.1016/j.corsci.2021.109398

Cited by 35 publications

(15 citation statements)

References 47 publications

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“…Three duplicates were used for the pH and ICP tests. The composition of the SBF solution referred to Reference [22].…”

Section: Immersion Testmentioning

confidence: 99%

“…For example, Zhang [19] controlled the degradation behavior and cytocompatibility of pure zinc by fabricating a graphene oxide-modified zinc-phosphate coating. Mo [22] fabricated an alendronate-dec- It has been proven that the microenvironment induced by biomaterials is greatly affected by the cell proliferation and differentiation on the implant [29]. Given this, bio-material with good biocompatibility is required.…”

Section: Cell Activity and Alp Activitymentioning

confidence: 99%

“…For example, Zhang [19] controlled the degradation behavior and cytocompatibility of pure zinc by fabricating a graphene oxide-modified zinc-phosphate coating. Mo [22] fabricated an alendronatedecorated zinc phosphate coating for pure zinc to reduce the degradation rate, and the bioactivity reported that the alendronate-decorated zinc phosphate coating could significantly decrease the corrosion rate and promote a pro-osteoblast response. Additionally, Zhuang found that the Ca-P coating could modulate the osteogenic differentiation of BM-SCs [30].…”

Section: Cell Activity and Alp Activitymentioning

confidence: 99%

“…A zinc-phosphate (ZnP) coating with graphene oxide was developed on pure zinc by Zhang [19] to improve the degradation behavior. Mo [22] also produced an alendronate-decorated zinc phosphate coating on pure zinc. Since the composition structure of calcium phosphate coatings is similar to human bone, the calcium phosphate coatings show excellent biocompatibility and a bone induction effect, which can promote the adhesion, proliferation, and differentiation of osteoblasts [23].…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Xie

Tang

et al. 2021

Coatings

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Zinc and its alloys show a good application prospect as a new biodegradable material. However, one of the drawbacks is that Zn and its alloys would induce the release of more Zn ions, which are reported to be cytotoxic to cells. In this study, a Ca-P-Sr bioactive coating was prepared on the surface of pure zinc by the hydrothermal method to address this issue. The morphology, thickness, and composition were characterized, and the effects of the coating on the degradation, cell viability, and ALP staining were investigated. The results demonstrated that the degradation rate of pure zinc was reduced, while the cytocompatibility was significantly improved after pure zinc was treated with Ca-P-Sr coating. It is considered that the Ca-P-Sr bioactive coating prepared by the hydrothermal method has promising application in the clinic.

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“…Three duplicates were used for the pH and ICP tests. The composition of the SBF solution referred to Reference [22].…”

Section: Immersion Testmentioning

confidence: 99%

Section: Cell Activity and Alp Activitymentioning

confidence: 99%

“…For example, Zhang [19] controlled the degradation behavior and cytocompatibility of pure zinc by fabricating a graphene oxide-modified zinc-phosphate coating. Mo [22] fabricated an alendronatedecorated zinc phosphate coating for pure zinc to reduce the degradation rate, and the bioactivity reported that the alendronate-decorated zinc phosphate coating could significantly decrease the corrosion rate and promote a pro-osteoblast response. Additionally, Zhuang found that the Ca-P coating could modulate the osteogenic differentiation of BM-SCs [30].…”

Section: Cell Activity and Alp Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Xie

Tang

et al. 2021

Coatings

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“…In addition, Zn has antimicrobial and biological properties that considerably reduce the risk of postoperative infection [11] Therefore, the development of degradable Zn for internal fracture fixation, vascular stents, and other implanted medical devices has good prospect. Furthermore, studies have found that Zn ions could react with sulfhydryl groups to inhibit bacterial activities such as glycolysis, transmembrane proton transfer, and acid resistance [15][16][17]. Therefore, scientists have focused on developing degradable Zn alloys as promising medical alloys for internal fracture fixation and as vascular stents and other implanted medical devices.…”

Section: Introductionmentioning

confidence: 99%

Corrosion and Biocompatibility of Pure Zn with a Micro-Arc-Oxidized Layer Coated with Calcium Phosphate

et al. 2021

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Recent studies have indicated a great demand to optimize the biocompatibility properties of pure Zn as an implant material. For this purpose, CaZn2(PO4)2·2H2O (CaZnP) was prepared using hydrothermal treatment (HT) combined with micro-arc oxidation (MAO) on pure Zn substrate to generate biodegradable implants. The polarization test and electrochemical impedance spectroscopy indicated that the MAO1−HT coating could modulate the corrosion behavior of MAO1 by filling the crevice between the coating and the substrate. Immersion test evaluation revealed that the osteogenic properties of MAO1−HT coating were better than that of pure Zn substrate, as evidenced by the molar ratio of Ca and P, which increased after soaking in simulated body fluid (SBF) for up to 10 days. In addition, L-929 cells cultured in the 100%, 50%, and 25% extracts of MAO1−HT coated samples exhibited excellent cytocompatibility. Meanwhile, cell adhesion was promoted on the surface with high roughness generated during MAO and HT processes. In summary, the calcified coatings improved biocompatibility and adjusted the degradation rates of pure Zn, broadening the application of Zn alloys.

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Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation

Xiang,

Vaquette,

Liu

et al. 2024

Adv Funct Materials

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Zinc (Zn) is gaining increased recognition as a biodegradable metal in biomedical applications but clinical translation is limited due to its poor biocompatibility. This study addresses these issues through an innovative biomimetic strategy, introducing an efficient surface nanoengineering approach that creates nano‐geometric features and chemical compositions by modulating the exposure time to a biological medium – Dulbecco's Modified Eagle Medium(DMEM). These nanoengineered Zn implants exhibited tunable degradation rates. The nanostructures enhanced human osteoblast attachment, proliferation, and differentiation following direct contact, and improved macrophage function by promoting pseudopod formation and transitioning from a pro‐inflammatory M1 to a pro‐reparative M2 phenotype. In vivo studies show that the surface‐engineered implants effectively promoted tissue integration via M2 macrophage polarization, resulting in a favorable immunomodulatory environment, and increased collagen deposition. Proteomic analyses show that the tissues in the vicinity of the surface‐engineered Zn implants are enriched with proteins related to key wound healing biological mechanisms such as cell adhesion, cytoskeletal structural arrangement, and immune response. This study highlights the improved biocompatibility and anti‐inflammatory effects of surface‐engineered Zn, with important implications for the clinical translation of biodegradable Zn‐based orthopedic implants.

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Corrosion and degradation decelerating alendronate embedded zinc phosphate hybrid coating on biodegradable Zn biomaterials

Cited by 35 publications

References 47 publications

Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Corrosion and Biocompatibility of Pure Zn with a Micro-Arc-Oxidized Layer Coated with Calcium Phosphate

Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation

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