Corrosion resistance and antibacterial activity of hydroxyapatite coating induced by ciprofloxacin-loaded polymeric multilayers on magnesium alloy

Ji, Xiaojing; Gao, Ling; Liu, Jiacheng; Jiang, Run-Zheng; Sun, Feiying; Cui, Lan-Yue; Li, Shuoqi; Zhi, Kangkang; Zeng, Rong‐Chang; Wang, Zhenlin

doi:10.1016/j.porgcoat.2019.06.048

Cited by 55 publications

(34 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diameter of the two semicircles obtained in the Nyquist diagram recorded in PBS increased significantly for the coated samples, indicating a higher increase of the polarization resistance, which led to higher decreases in the corrosion rate. The Nyquist diagram showed the presence of an inductive loop recorded at a low frequency for all tested samples because of the pitting corrosion initiation [ 91 ]. Furthermore, the corrosion resistance could be estimated from the Bode diagrams.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Macrophage Immunomodulation by Poly(ε-caprolactone) Based-Coated AZ31 Mg Alloy

Negrescu

Necula

Gebaur

et al. 2021

IJMS

View full text Add to dashboard Cite

Due to its excellent bone-like mechanical properties and non-toxicity, magnesium (Mg) and its alloys have attracted great interest as biomaterials for orthopaedic applications. However, their fast degradation rate in physiological environments leads to an acute inflammatory response, restricting their use as biodegradable metallic implants. Endowing Mg-based biomaterials with immunomodulatory properties can help trigger a desired immune response capable of supporting a favorable healing process. In this study, electrospun poly(ε-caprolactone) (PCL) fibers loaded with coumarin (CM) and/or zinc oxide nanoparticles (ZnO) were used to coat the commercial AZ31 Mg alloy as single and combined formulas, and their effects on the macrophage inflammatory response and osteoclastogenic process were investigated by indirect contact studies. Likewise, the capacity of the analyzed samples to generate reactive oxygen species (ROS) has been investigated. The data obtained by attenuated total reflection Fourier-transform infrared (FTIR-ATR) and X-ray photoelectron spectroscopy (XPS) analyses indicate that AZ31 alloy was perfectly coated with the PCL fibers loaded with CM and ZnO, which had an important influence on tuning the release of the active ingredient. Furthermore, in terms of degradation in phosphate-buffered saline (PBS) solution, the PCL-ZnO- and secondary PCL-CM-ZnO-coated samples exhibited the best corrosion behaviour. The in vitro results showed the PCL-CM-ZnO and, to a lower extent, PCL-ZnO coated sample exhibited the best behaviour in terms of inflammatory response and receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated differentiation of RAW 264.7 macrophages into osteoclasts. Altogether, the results obtained suggest that the coating of Mg alloys with fibrous PCL containing CM and/or ZnO can constitute a feasible strategy for biomedical applications.

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro Macrophage Immunomodulation by Poly(ε-caprolactone) Based-Coated AZ31 Mg Alloy

Negrescu

Necula

Gebaur

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…The obtained sample exhibited antibacterial function, but at the same time, the multilayer film will accelerate the corrosion rate of the Mg substrate. Ji et al [114] constructed the CIP-loaded multilayers on AZ31 Mg alloy through dip-LbL, and then prepared a hydroxyapatite coating by hydrothermal treatment. The composite coating showed 98.7% and 95.2% antibacterial activities against E. coli and S. aureus due to the release of CIP [115].…”

Section: Antibacterial Coatingsmentioning

confidence: 99%

Advances in layer-by-layer self-assembled coatings upon biodegradable magnesium alloys

Shao

et al. 2021

Sci. China Mater.

Self Cite

View full text Add to dashboard Cite

Magnesium (Mg) and its alloys are considered as ideal biodegradable materials due to their excellent mechanical properties and biocompatibility. In order to improve the surface properties to allow better adaptation to the surrounding tissue of the body, surface modification has played a significant role in satisfying multiple clinical requirements such as corrosion resistance, biocompatibility, and antibacterial ability. Here, layer-by-layer (LbL) self-assembly, which can be applied for biodegradable Mg alloys due to its extensive choice of usable units, holds great promise among all the surface techniques. In this review, the mechanisms of the driving force (i.e., electrostatic interaction, hydrogen bonding, charge transfer interaction and covalent bonding), cuttingedge advances in preparation methods (e.g., dipping, spraying, and spinning) and the functional properties (corrosion resistance, antibacterial activity, and biocompatibility) that could be achieved by the LbL coatings are summarized. A reasonable trend of the potential development of LbL for bio-Mg alloys is also proposed at the end of this article.

show abstract

“…If a biofilm forms on the implant surface, bacteria will increase the corrosion rate and drug resistance may ensue. In this respect, controlled release of bactericides such as antibiotics 7‐10 is a common method. A multilayered coating composed of polymeric middle layers containing polyacrylic acid (PAA), water‐soluble polymer with a high binding capacity that can contribute to the formation of a Ca‐P coating due to the interaction between ─COO─ and Ca 2+ , poly(ethylenimine) (PEI), and cationic polymer can effectively permeate the outer membrane of Gram‐negative bacteria 7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…In this respect, controlled release of bactericides such as antibiotics 7‐10 is a common method. A multilayered coating composed of polymeric middle layers containing polyacrylic acid (PAA), water‐soluble polymer with a high binding capacity that can contribute to the formation of a Ca‐P coating due to the interaction between ─COO─ and Ca 2+ , poly(ethylenimine) (PEI), and cationic polymer can effectively permeate the outer membrane of Gram‐negative bacteria 7,8 . The hydroxyapatite (HA) or calcium phosphate coating on top enhances osseointegration and cytocompatibility and improves binding between bone tissues and implant materials in the human body 7‐10 .…”

Section: Introductionmentioning

confidence: 99%

“…Among the various coating techniques, layer‐by‐layer (LbL) assembly is a versatile approach for local drug delivery systems as well as bioactive and antibacterial coatings. Ciprofloxacin (Cip) is a fluoroquinolone antibiotic that fights both gram‐positive and gram‐negative bacteria and the interactions between ─COO─ and Ca 2+ as well as Cip molecules with carboxylate groups facilitate the formation of HA layers with a more compact structure 7,8 . The hydroxyapatite or calcium phosphate layers with a flaky and flat morphology causes release of antibiotics from the porous structure and the surface defects in the calcium phosphate coating increases local corrosion, consequently expediting degradation of the magnesium alloy 7‐10 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced corrosion resistance and reduced cytotoxicity of the AZ91 Mg alloy by plasma nitriding and a hierarchical structure composed of ciprofloxacin‐loaded polymeric multilayers and calcium phosphate coating

Shanaghi

Mehrjou

Chu

2021

J Biomedical Materials Res

View full text Add to dashboard Cite

Much effort has made to lessen the cytotoxicity and enhance the corrosion resistance of biodegradable magnesium alloys, for example, by depositing multilayered polymeric coatings containing hydroxyapatite. In this work, a hierarchical structure composed of ciprofloxacin (Cip)‐loaded on polyacrylic acid (PAA) and poly (ethyleneimine) (PEI) as biocompatible polymeric multilayers and calcium phosphate coating as the top layer is formed by the sol–gel method on the AZ91 Mg alloy with an intermediate layer formed by nitrogen plasma immersion ion implantation. The thicknesses of the multilayered coating and nitrided layer (Mg3N2) are 10 μm and 140 nm, respectively. The corrosion current density decreases by 95.6% and the corrosion potential in the polarization curve shifts to the positive direction by 23%. The passivation process which occurs at defects by deposition of corrosion products mitigates both galvanic and localized corrosion. Slight increase in the contact angle and surface free energy, enhanced corrosion resistance, and reduced cytotoxicity are observed from the multilayered structure. The better corrosion resistance enables better control of release of Cip. Biological assessment indicates that the antibacterial activity against Escherichia coli is improved by 100% after culturing for 24 hr and the cell viability and noncytotoxic behavior of the coated AZ91 are enhanced as well. The corrosion behavior and biological results suggest that the strategy of using a hierarchical structure composed of Cip‐loaded polymeric multilayers in conjunction with an intermediate plasma nitrided layer has large potential in the development of biodegradable orthopedic implants made of Mg alloys.

show abstract

Corrosion resistance and antibacterial activity of hydroxyapatite coating induced by ciprofloxacin-loaded polymeric multilayers on magnesium alloy

Cited by 55 publications

References 45 publications

In Vitro Macrophage Immunomodulation by Poly(ε-caprolactone) Based-Coated AZ31 Mg Alloy

In Vitro Macrophage Immunomodulation by Poly(ε-caprolactone) Based-Coated AZ31 Mg Alloy

Advances in layer-by-layer self-assembled coatings upon biodegradable magnesium alloys

Enhanced corrosion resistance and reduced cytotoxicity of the AZ91 Mg alloy by plasma nitriding and a hierarchical structure composed of ciprofloxacin‐loaded polymeric multilayers and calcium phosphate coating

Contact Info

Product

Resources

About