Corrosion resistance of bioinspired DNA-induced Ca–P coating on biodegradable magnesium alloy

Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores

“…Additionally, the DNA-based coatings are rather stable as complexation of DNA with cationic polyelectrolytes protects DNA from degradation by nucleases [ 43 , 44 ]. Phosphate groups of the DNA backbone can bind Ca 2+ ions and promote the deposition of Ca-P complexes ( Figure 2 c), which made DNA an attractive component for producing coatings for bone implants [ 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. The complexation of DNA with various cytocompatible polycations, such as chitosan, polyamino acids and protamine, DNA/poly- d -lysine or DNA/poly(allylamine hydrochloride) was tested [ 44 , 45 , 52 , 53 , 54 , 55 , 56 ].…”

“…Reproduced from [ 58 ] under the Creative Commons Attribution (CC BY) license ( , accessed on 25 November 2021; the mechanism of DNA-induced Ca-P deposition on the surface of Mg alloy ( c ). Reproduced without modifications from [ 50 ] under the CC BY-NC-ND license ( , accessed on 25 November 2021); the images of SYTO-9-stained bacterial biofilms adhered to stainless steel surfaces after 48 incubation obtained by fluorescent microscopy (scale bar is 20 µm) ( d ) and the surface coverage by the bacteria after 48 h growth ( e ). A statistically significant decrease in bacterial adhesion to DNA-coated surface compared to the uncoated one is indicated by an asterisk.…”

Micro/Nano‐Structured Metal–Organic/Inorganic Hybrid Coatings on Biodegradable Zn for Osteogenic and Biocompatible Improvement

“…Bioactive molecules have been increasingly used as important components for the surface modification of metallic biomaterials to improve bio‐functionalities, but few studies have been reported on their incorporation with inorganic phases to form hybrid coatings on biodegradable metals. Some attempts have been tried to co‐deposit biomolecules of amino acids or proteins with CaP to improve the quality of coatings and their biocompatibility on Mg surfaces, [ 14 ] whereas such co‐deposition process was insufficient to build up a well‐structured system. A well‐structured attribute is of equally critical importance for the coatings’ functionalities, especially for warranting a similar or biomimetic structure of the organic–inorganic components to the natural bone matrix.…”

“…Amino acids such as Cys and Phe are typical small bio‐molecules with active groups to coordinate readily with the metal ions, which may serve as the nucleation site and further template for the growth of phosphate coating on metallic substrates. [ 14b,c,15 ] In addition, Cys and Phe contain two ionizable groups (amino group (NH 2 ), and carboxyl group (COOH), which appear opposite chemical properties. The Cys molecule contains also a mercapto group (SH).…”

Corrosion Behavior and Biocompatibility of Na2EDTA-Induced Nacre Coatings on AZ91D Alloys Prepared via Hydrothermal Treatment

“…Various techniques, such as sol-gel ( Su et al, 2018 ). Electrodeposition ( Horynová et al, 2019 ), RF magnetron sputtering ( Acheson et al, 2019 ), plasma electrolytic oxidation ( Fu et al, 2019 ), chemical conversion ( Duan et al, 2018 ; Zhang et al, 2019 ; Asl et al, 2020 ; Liu et al, 2020 ), and hydrothermal deposition ( Tomozawa et al, 2010 ; Hiromoto and Tomozawa, 2011 ; Tomozawaa and Hiromoto, 2011 ; Li et al, 2012 ; Hiromotoa et al, 2013 ; Ohtsu et al, 2013 ; Liu P et al, 2019 ), have been used to deposit CaP coatings on Mg alloy substrates. Among these techniques, hydrothermal deposition is the simplest and most cost-effective because it only needs a single step of immersion ( Zhang et al, 2018 ).…”