Corrosive Effect of Nifedipine in the Upper Gastrointestinal Tract

Lavy, Alexandra

doi:10.1155/dte.6.39

Cited by 7 publications

(1 citation statement)

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“…This drug has shown a wide range of therapeutic effect, but often it is abandoned due to side effects such as pronounced hypotension, diarrhea, hepatotoxicity, mental confusion, and even death (Hedner 1986; Kloner 1995). It has also been shown to cause gastritis in the GI tract (Lavy 1999). These side effects, however, are primarily the result of excess drug in the dose as is required for current oral formulation.…”

Section: Introductionmentioning

confidence: 99%

Nifedipine nanoparticle agglomeration as a dry powder aerosol formulation strategy

Plumley

Gorman

El-Gendy

et al. 2009

International Journal of Pharmaceutics

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Efficient administration of drugs represents a leading challenge in pulmonary medicine. Dry powder aerosols are of great interest compared to traditional aerosolized liquid formulations in that they may offer improved stability, ease of administration, and simple device design. Particles 1-5 µm in size typically facilitate lung deposition. Nanoparticles may be exhaled as a result of their small size; however, they are desired to enhance the dissolution rate of poorly soluble drugs. Nanoparticles of the hypertension drug nifedipine were co-precipitated with stearic acid to form a colloid exhibiting negative surface charge. Nifedipine nanoparticle colloids were destabilized by using sodium chloride to disrupt the electrostatic repulsion between particles as a means to achieve the agglomerated nanoparticles of a controlled size. The aerodynamic performance of agglomerated nanoparticles was determined by cascade impaction. The powders were found to be well suited for pulmonary delivery. In addition, nanoparticle agglomerates revealed enhanced dissolution of the drug species suggesting the value of this formulation approach for poorly water soluble pulmonary medicines. Ultimately, nifedipine powders are envisioned as an approach to treat pulmonary hypertension.

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Section: Introductionmentioning

confidence: 99%