Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry

Nugent, Allison C.; Milham, Michael P.; Bain, Earle; Mah, Linda; Cannon, Dara M.; Marrett, Sean; Zarate, Carlos A.; Pine, Daniel S.; Price, Joseph L.; Drevets, Wayne C.

doi:10.1016/j.neuroimage.2005.09.029

Cited by 198 publications

(159 citation statements)

References 66 publications

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“…The limbic-cortical-striatal-pallidal-thalamic circuit formed by these regions also interacts with other orbitomedial PFC, temporal lobe (eg, STG, parahippocampal cortex), and cingulate regions (mid-and posterior cingulate cortices) to form the visceromotor network, which modulates the endocrine, autonomic, and experiential aspects of emotional behavior (Kondo et al, 2005;Ongur et al, 2003;Ongur and Price, 2000). The two regions in which tryptophan depletion increased BOLD response to negative relative to positive words, the STG, and posterior cingulate cortex, have also consistently been implicated in unipolar depression Nugent et al, 2006). Both areas share extensive, monosynaptic anatomical connections with the orbitomedial PFC regions associated with the visceromotor network (Ongur et al, 2003), and have been implicated in verbal processing, particularly the processing of emotionally valenced verbal stimuli (Cato et al, 2004;Kuchinke et al, 2005;Maddock et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Roiser

Lévy

Fromm

et al. 2007

Neuropsychopharmacol

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The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.

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Section: Discussionmentioning

confidence: 99%

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

Roiser

Lévy

Fromm

et al. 2007

Neuropsychopharmacol

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“…117 Recent findings also indicate GM volume reductions in left VLPFC in medicated adult BD compared with healthy individuals, 118 although not in first-episode BD. 119 Genetic risk for BD has been specifically associated with GM deficits in right ACG, including subgenual, rostral and more dorsal components, and ventral striatum, 120 and a recent report provides evidence of an early neurodevelopmental abnormality in bilateral ACG in adult BD.…”

Section: Adult Bipolar Disordermentioning

confidence: 99%

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

2008

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The ability to regulate emotions is an important part of adaptive functioning in society. Advances in cognitive and affective neuroscience and biological psychiatry have facilitated examination of neural systems that may be important for emotion regulation. In this critical review we first develop a neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses. We then use this model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.

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“…This circuitry participates in the guidance of reward-related behaviors such as feeding, while dysfunction of this circuitry has been implicated in depression, anhedonia, impaired decision making, and addiction (Bechara, 1994;Franklin et al, 2002;Goldstein and Volkow, 2002;Grant et al, 2000;Kelley, 2005;Nugent et al, 2006;Robbins, 2007;Rogers and Robbins, 2001). …”

Section: Initial Exposurementioning

confidence: 99%

The effects of cocaine: A shifting target over the course of addiction

Porrino

Smith

Nader

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

158

129

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Repeated exposure to psychostimulant drugs such as cocaine has been shown in numerous studies to produce significant neuroadaptations in both structure and function throughout the brain. Nonhuman primate models provide a way to systematically evaluate these adaptations engendered by cocaine self-administration and simulate the progressive nature of cocaine addiction in humans. Functional activity, measured using the 2-[ 14 C]deoxyglucose method, was evaluated at selected critical time points over the course of chronic cocaine self-administration in rhesus monkeys. The effects of cocaine exposure in the initial stages of self-administration resulted in changes in functional activity in a highly restricted network of interconnected brain regions when compared to activity in food-reinforced controls. This pattern of changes was confined mainly to ventromedial prefrontal cortex and ventral striatum. Following chronic exposure to cocaine self-administration, however, the spatial extent and intensity of significant alterations in functional activity expanded considerably. The shift in topography of these changes was orderly, originating ventromedially in the prefrontal cortical-ventral striatal network and expanding dorsally to encompass the dorsal striatum. A strikingly similar progression occurred within the cortical areas that project to each of these striatal regions. Preliminary studies suggest that this pattern is maintained despite periods of abstinence from cocaine. The shifting patterns of cerebral metabolic function that accompany longer durations of cocaine self-administration may underlie many of the characteristics of chronic drug exposure, and may provide transitional mechanisms to more compulsive cocaine use.

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Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry

Cited by 198 publications

References 66 publications

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

The effects of cocaine: A shifting target over the course of addiction

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