Cortical Activations During Auditory Verbal Hallucinations in Schizophrenia: A Coordinate-Based Meta-Analysis

Jardri, Renaud; Pouchet, Alexandre; Pins, Delphine; Thomas, Pierre

doi:10.1176/appi.ajp.2010.09101522

Cited by 569 publications

(468 citation statements)

References 97 publications

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“…The pre/postcentral gyrus is primarily considered to be involved in somatosensory processing and motor functions, but its role has more recently been shown to also include higher cognitive tasks including executive functioning and linguistic processing (Whalley et al, 2004;Minzenberg et al, 2009). It is also reported to be affected in SCZ (Tanskanen et al, 2010;Job et al, 2002;Zhou et al, 2005;Glahn et al, 2008), and there are reports of associations of abnormalities in this region with clinical symptoms seen in the disorder (Kircher et al, 2001;Zhou et al, 2005;Nenadic et al, 2010;Jardri et al, 2011) together with neurological soft signs such as sensory integration deficits (Dazzan et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Whalley

Papmeyer

Romaniuk

et al. 2012

Neuropsychopharmacol

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A recent 'mega-analysis' combining genome-wide association study data from over 40 000 individuals identified novel genetic loci associated with schizophrenia (SCZ) at genome-wide significance level. The strongest finding was a locus within an intron of a putative primary transcript for microRNA MIR137. In the current study, we examine the impact of variation at this locus (rs1625579, G/T; where T is the common and presumed risk allele) on brain activation during a sentence completion task that differentiates individuals with SCZ, bipolar disorder (BD), and their relatives from controls. We examined three groups of individuals performing a sentence completion paradigm: (i) individuals at high genetic risk of SCZ (n ¼ 44), (ii) individuals at high genetic risk of BD (n ¼ 90), and (iii) healthy controls (n ¼ 81) in order to test the hypothesis that genotype at rs1625579 would influence brain activation. Genotype groups were assigned as 'RISKÀ' for GT and GG individuals, and 'RISK + ' for TT homozygotes. The main effect of genotype was significantly greater activation in the RISKÀ individuals in the posterior right medial frontal gyrus, BA 6. There was also a significant genotype*group interaction in the left amygdala and left pre/postcentral gyrus. This was due to differences between the controls (where individuals with the RISKÀ genotype showed greater activation than RISK + subjects) and the SCZ high-risk group, where the opposite genotype effect was seen. These results suggest that the newly identified SCZ locus may influence brain activation in a manner that is partly dependent on the presence of existing genetic susceptibility for SCZ.

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Section: Discussionmentioning

confidence: 99%

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Whalley

Papmeyer

Romaniuk

et al. 2012

Neuropsychopharmacol

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“…The small volume contained regions previously reported to be involved in the experience of AVH. [11][12][13][14] These regions, comprising the bilateral inferior frontal gyri, insula, superior and middle temporal gyri (including the superior and middle temporal pole), supramarginal gyri, precentral and postcentral gyri, cerebellum, hippocampus, and parahippocampal gyrus were defined using the Automated In the last 3 months. *Significant at P < .05; **Significant after Bonferroni correction for the number of PSYRATS items (n = 10; P < .005).…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14] Thus far, only one study investigated brain activation during AVH in nonclinical individuals. 15 This study included seven nonclinical individuals with AVH and 7 control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies investigated AVH-related brain activation in psychotic patients, primarily reporting activation of bilateral frontal and temporoparietal areas. [11][12][13][14] Thus far, only one study visualized AVH-related brain activation in nonpsychotic subjects, revealing activation in bilateral frontal and temporoparietal areas as well as motor areas. 15 However, this study included only 7 subjects and did not compare AVH-related brain activation in their group of nonpsychotic subjects to that of psychotic patients.…”

Section: Introductionmentioning

confidence: 99%

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Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Non-Psychotic Individuals

Sommer¹

2012

Schizophrenia Research

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While auditory verbal hallucinations (AVH) are most characteristic for schizophrenia, they also occur in nonpsychotic individuals in the absence of a psychiatric or neurological disorder and in the absence of substance abuse. At present, it is unclear if AVH in these nonpsychotic individuals constitute the same phenomenon as AVH in psychotic patients. Comparing brain activation during AVH between nonpsychotic and psychotic individuals could provide important clues regarding this question. 21 nonpsychotic subjects with AVH and 21 matched psychotic patients indicated the presence of AVH during 3T functional magnetic resonance imaging (fMRI) scanning. To identify common areas of activation during the experience of AVH in both groups, a conjunction analysis was performed. In addition, a 2-sample t-test was employed todiscover possible differencesin AVH-related activation between the groups. Several common areas of activation were observed for the psychotic and nonpsychotic subjects during the experience of AVH, consisting of the bilateral inferior frontal gyri, insula, superior temporal gyri, supramarginal gyri and postcentral gyri, left precentral gyrus, inferior parietal lobule, superior temporal pole, and right cerebellum. No significant differences in AVH-related brain activation were present between the groups. The presence of multiple common areas of AVH-related activation in psychotic and nonpsychotic individuals, in the absence of significant differences, implicates the involvement of the same cortical network in the experience of AVH in both groups.

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“…Neuroimaging studies have highlighted that these symptoms might be linked to abnormal brain activities within large dysfunctional brain networks. Auditory verbal hallucinations have been linked to fronto-temporal abnormalities with an hyperactivity in the left temporo-parietal junction [70] and negative symptoms have been linked to hypoactivity in the right and left prefrontal cortex [71] . Thanks to the excitatory effect of the anode and the inhibitory effect of the cathode described in the neurophysiological studies investigating the effect of tDCS on motor cortex excitability, it has been hypothesized that anodal tDCS applied over the left prefrontal cortex (hypoactive) combined with cathodal tDCS applied over the left temporo-parietal junction (hyperactive) could alleviate auditory hallucinations in patients with schizophrenia (for a review see Mondino [72] ).…”

Section: Schizophreniamentioning

confidence: 99%

Transcranial direct current stimulation in psychiatric disorders

Tortella¹,

Casati²,

Aparicio³

et al. 2015

WJP

138

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The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation (tDCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally, REVIEWSubmit a

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Cortical Activations During Auditory Verbal Hallucinations in Schizophrenia: A Coordinate-Based Meta-Analysis

Cited by 569 publications

References 97 publications

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Auditory Hallucinations Elicit Similar Brain Activation in Psychotic and Non-Psychotic Individuals

Transcranial direct current stimulation in psychiatric disorders

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