Cortical and peripheral modification of cerebellar climbing fibre activity arising from cutaneous mechanoreceptors

Leicht, R.; Rowe, Mark J.; Schmidt, Robert F.

doi:10.1113/jphysiol.1973.sp010103

Cited by 35 publications

(23 citation statements)

References 25 publications

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“…Hence it appears that the probability of convergence of CF inputs from SI is greater for Purkinje cells having large peripheral receptive fields, than for cells with small receptive fields. The convergence figures for the small receptive fields on the face are in good agreement with those reported by Leicht et al (1973b), who found CF convergence from small areas of hind-limb or forelimb skin, and from the corresponding SI projection, in thirty-four of sixty-four (53 %) of Purkinje cells tested.…”

Section: Ipsilateral VIIsupporting

confidence: 90%

Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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Section: Ipsilateral VIIsupporting

confidence: 90%

Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Miles¹,

Wiesendanger²

1975

The Journal of Physiology

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“…By analogy, although not necessarily due to the same mechanism, inhibitory receptive fields of single climbing fibres have been described by Leicht, Rowe & Schmidt (1973). Both observations demonstrate the existence of afferent inhibitory control of transmission in the spino-olivocerebellar pathways and it is an interesting possibility that the movement-related gating is an expression of increased afferent inhibition subserving mechanisms for enhanced spatial contrast.…”

Section: C1ïc3 Versus C2 Recording Sitesmentioning

confidence: 72%

Gating of cutaneous input to cerebellar climbing fibres during a reaching task in the cat

Apps

Atkins

Garwicz

1997

The Journal of Physiology

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Task‐dependent modulation of cutaneous input to climbing fibres projecting to the C1, C2 and C3 zones in the cerebellar paravermal lobule V was investigated in awake cats during performance of a reaching task. Climbing fibre responses resulting from low intensity (non‐noxious) electrical stimulation of the ipsilateral superficial radial nerve were recorded as extracellular field potentials in the cerebellar cortex using chronically implanted microwires. Response size, measured as the time–voltage integral of the evoked field potential, was assessed during three phases of the reaching movement, reaction, reach and grasp, and compared with the response size at rest. At C1 and C3 zone recording sites response size was usually reduced during the task (7/10 sites). The reduction was most pronounced in the grasp phase, occasionally accompanied by a smaller reduction in the reach and reaction phases. In one case an enhancement was found in the reach phase. Response size was also modulated during the task at four of six C2 zone recording sites. However, the results were mixed. In three cases the modulation resembled the pattern at C1/C3 sites with the responses being reduced in the grasp phase accompanied on occasion by a lesser reduction in the reach phase. In the remaining case there was an enhancement during grasp. In this case and one other there was also an enhancement during the reaction phase. The findings indicate significant gating of cutaneous input to climbing fibres projecting to the C1, C2 and C3 zones during reaching movements, while the variability between recording sites suggests functional differences, both between and within zones.

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“…6). In both groups there was evidence of peripheral and corticofugal control of the cutaneously evoked CF activity (Leicht et al 1973). …”

Section: Discussionmentioning

confidence: 96%

Cutaneous convergence on to the climbing fibre input to cerebellar Purkyně cells

Leicht¹,

Rowe²,

Schmidt³

1973

The Journal of Physiology

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SUMMARY1. In cats anaesthetized with Nembutal, the cutaneous receptive fields of individual cerebellar climbing fibres were assessed by recording the climbing fibre responses of single Purkyn6 cells following controlled mechanical stimulation (air jets, vibration, taps, pressure) of the foot pads of all four limbs and of the hairy skin of the limbs and the body.2. Three major types of cutaneous receptive fields of individual climbing fibres were recognized: (a) restricted fields generally confined to the distal areas of one limb only; (b) circumscribed fields on the distal areas of two to four limbs (discontinuous fields); and (c) widespread continuous fields extending over all or almost all of the body surface. A fourth group appears to receive cutaneous inputs from one limb and sensory input from deeper structures in other limbs.3. Thresholds for tapping of the foot pads were often quite low (< 100,um indentation), and there was no noticeable difference in the distribution of thresholds between the climbing fibres having restricted or more widespread cutaneous receptive fields. Similarly, the latencies of climbing fibre responses evoked by vibration and tapping were in the same ranges for climbing fibres with receptive fields restricted to one limb only and for those having more widespread fields. 4. In regard to location in the anterior lobe of the cerebellum it was found that those climbing fibres receiving inputs only from the ipsilateral forelimb projected to Purkyn6 cells located almost entirely in lobule V, whereas all other climbing fibres with restricted or more widespread receptive fields projected to Purkyn6 cells distributed widely within lobules II to V.

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Cortical and peripheral modification of cerebellar climbing fibre activity arising from cutaneous mechanoreceptors

Cited by 35 publications

References 25 publications

Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Climbing fibre inputs to cerebellar Purkinje cells from trigeminal cutaneous afferents and the SI face area of the cerebral cortex in the cat.

Gating of cutaneous input to cerebellar climbing fibres during a reaching task in the cat

Cutaneous convergence on to the climbing fibre input to cerebellar Purkyně cells

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