Cortical excitability changes following grasping exercise augmented with electrical stimulation

Barsi, Gergely István; Popović, Dejan B.; Tarkka, Ina M.; Sinkjær, Thomas; Grey, Michael J.

doi:10.1007/s00221-008-1495-5

Cited by 130 publications

(105 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The duration of SP in healthy humans is linearly related to the stimulus intensity and it is generated by both the intracortical and peripheral mechanisms and, in addition, it is altered in several neurologic diseases (Barsi et al 2008;Daskalakis et al 2008;Säisänen et al 2008). In the present study, the SP durations remained unaffected throughout the study in both hemispheres and in both groups while the MEP latencies shortened in FET group.…”

Section: Discussionsupporting

confidence: 46%

“…This suggests that FET had a specific excitatory effect in the neural circuitry controlling affected hand muscles having no measurable effect on the inhibitory cortical circuitry in these subjects. Previous studies assessing the effects of functional electrical stimulation (FES) in healthy subjects have similarly failed to show any effect on SP duration even though they have shown excitability changes in MEPs also after very short FES exposures (Kido Thompson and Stein 2004;Barsi et al 2008). It is likely that the corticospinal excitability and the control of cortical inhibition are dissociated in their response to peripheral functional electrical stimulation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Electrical Therapy for Hemiparesis Alleviates Disability and Enhances Neuroplasticity

Tarkka

Pitkänen

Popović

et al. 2011

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

Impaired motor and sensory function is common in the upper limb in humans after cerebrovascular stroke and it often remains as a permanent disability. Functional electrical stimulation therapy is known to enhance the motor function of the paretic hand; however, the mechanism of this enhancement is not known. We studied whether neural plasticity has a role in this therapy-induced enhancement of the hand motor function in 20 hemiparetic subjects with chronic stroke (age 53 ± 6 years; 7 females and 13 males; 10 with cerebral infarction and 10 with cerebral haemorrhage; and time since incident 2.4 ± 2.0 years). These subjects were randomized to functional electrical therapy or conventional physiotherapy group. Both groups received upper limb treatment (twice daily sessions) for two weeks. Behavioral hand motor function and neurophysiologic transcranial magnetic stimulation (TMS) tests were applied before and after the treatment and at 6-months follow-up. TMS is useful in assessing excitability changes in the primary motor cortex. Faster corticospinal conduction and newly found muscular responses were observed in the paretic upper limb in the functional electrical therapy group but not in the conventional therapy group after the intervention. Behaviourally, faster movement times were observed in the functional electrical therapy group but not in the conventionally treated group. Despite the small number of heterogeneous subjects, functional exercise augmented with individualized electrical therapy of the paretic upper limb may enhance neuroplasticity, observed as corticospinal facilitation, in chronic stroke subjects, along with moderate improvements in the voluntary motor control of the affected limb.

show abstract

Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Functional Electrical Therapy for Hemiparesis Alleviates Disability and Enhances Neuroplasticity

Tarkka

Pitkänen

Popović

et al. 2011

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…By contrast, the combination of a motor task (swallowing) with functional electrical stimulation (PES) was ineffective. Earlier research regarding hand and leg rehabilitation using motor training with sensory stimulation suggested that that this type of combined stimuli can induce larger changes in excitability and/or neuroplasticity in motor cortex [39][40][41] , whereas tongue protrusion motor training, which alone produces measured neuroplasticity and successful performance, was less effective on motor cortex with nociceptive sensory stimulation. 42 These may be due to the differences in the neural systems between spinal and cranial nerves or in the type of experimental noxious stimulus.…”

Section: Changes In the Corticobulbar Neural Circuitmentioning

confidence: 99%

Exploring the effects of synchronous pharyngeal electrical stimulation with swallowing carbonated water on cortical excitability in the human pharyngeal motor system

Magara

Michou

Raginis-Zborowska

et al. 2016

Neurogastroenterology Motil

View full text Add to dashboard Cite

Key Points• Excitation of human pharyngeal motor cortex can be induced by pharyngeal electrical stimulation (PES) and swallowing carbonated water (CW). This study was undertaken to investigate the effect of synchronously combining PES with swallowing CW.• Pharyngeal cortical and brainstem excitation was investigated using transcranial or transcutaneous magnetic stimulation (TMS).• PES was most effective at inducing excitation in the pharyngeal motor cortex. Combination of PES and CW were less effective in producing cortical excitability but induced transient excitation in the brainstem. Our data indicate the PES may be more advantageous than combined swallowing stimuli for driving cortical changes in the swallowing system which may be useful in dysphagia rehabilitation. AbstractBackground Previous reports have revealed that excitation of human pharyngeal motor cortex can be induced by pharyngeal electrical stimulation (PES) and swallowing carbonated water (CW). This study investigated whether combining PES with swallowing (of still water, SW or CW) can potentiate this excitation in either cortical and/or brain stem areas assessed with transcranial and transcutaneous magnetic stimulation (TMS). Methods Fourteen healthy volunteers participated and were intubated with an intraluminal catheter to record pharyngeal electromyography and deliver PES. Each participant underwent baseline corticopharyngeal, hand and craniobulbar motor-evoked potential (MEP) measurements. Subjects were then randomized to receive each of four 10-min interventions (PES only, Sham-PES+CW, PES+CW, and PES+SW). Corticobulbar, craniobulbar and hand MEPs were then remeasured for up to 60 min and data analyzed using ANOVA and post hoc t-tests. Key Results A two-way rmANOVA for Interventions 9 Time-point showed a significant corticopharyngeal interaction (p = 0.010). One-way ANOVA with post hoc t-tests indicated significant cortical changes with PES only at 45 (p = 0.038) and 60 min (p = 0.023) and ShamPES+CW immediately (p = 0.008) but not with PES+CW or PES+SW. By contrast, there were immediate craniobulbar amplitude changes only with PES+CW (p = 0.020) which were not sustained. Conclusions & Inferences We conclude that only PES produced long-term changes in corticopharyngeal excitability whereas combination stimuli were less effective. Our data suggest that PES alone rather than in combination, may be better for the patients who have difficulty in performing voluntary swallows.

show abstract

“…induce plasticity in the motor cortex and to be an effective approach in rehabilitation after stroke [6].…”

Section: Introductionmentioning

confidence: 99%

A Measurement of Lower Limb Angles Using Wireless Inertial Sensors during FES Assisted Foot Drop Correction with and without Voluntary Effort

Watanabe¹,

Endo²,

Murakami³

et al. 2013

IJBBB

View full text Add to dashboard Cite

Abstract-An integrated wireless system of lower limb angle measurement and Functional Electrical Stimulation (FES) control was developed in our previous study for application to motor rehabilitation. In the motor rehabilitation, it is also considered that voluntary effort to move their limbs is effective. In this paper, gait movements of a hemiplegic subject were measured with and without voluntary effort of ankle dorsiflexion during FES assisted foot drop correction as a preliminary test for gait rehabilitation with FES. Some characteristics of hemiplegic gait and differences in joint angles between the paralyzed and the non-paralyzed sides were found in the measurement. The foot and the shank inclination angles at the toe off timing showed small change with the voluntary effort of dorsiflexion during FES control. In addition, variations of the inclination angles of some segments of the paralyzed side were larger than those with only FES at the toe off timing, maximum angle point and the foot contact timing in the case of the voluntary effort. These results suggested that voluntary effort could change movement in FES control. However, these changes with voluntary effort were not seen with larger stimulation intensity. Therefore, it was considered that the movement changes with voluntary effort were small because the subject could not produce further voluntary muscle force in excess of the muscle force production by FES. It would be necessary to determine appropriate intensity of electrical stimulation for rehabilitation use.

show abstract

Cortical excitability changes following grasping exercise augmented with electrical stimulation

Cited by 130 publications

References 43 publications

Functional Electrical Therapy for Hemiparesis Alleviates Disability and Enhances Neuroplasticity

Functional Electrical Therapy for Hemiparesis Alleviates Disability and Enhances Neuroplasticity

Exploring the effects of synchronous pharyngeal electrical stimulation with swallowing carbonated water on cortical excitability in the human pharyngeal motor system

A Measurement of Lower Limb Angles Using Wireless Inertial Sensors during FES Assisted Foot Drop Correction with and without Voluntary Effort

Contact Info

Product

Resources

About