2010
DOI: 10.1016/j.neuroscience.2010.05.052
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Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

Abstract: Using two in vivo methods, microdialysis and rapid in situ electrochemistry, this study examined the modulation of extracellular glutamate levels by endogenously produced kynurenic acid (KYNA) in the prefrontal cortex (PFC) of awake rats. Measured by microdialysis, intraperitoneal (i.p.) administration of KYNA's bioprecursor L-kynurenine dose-dependently elevated extracellular KYNA and reduced extracellular glutamate (nadir after 50 mg/kg kynurenine: 60% decrease from baseline values). This dose-dependent decr… Show more

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Cited by 86 publications
(77 citation statements)
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“…Examination of this relationship with linear regression found that the KYN/TRP still predicted white matter glutamate after controlling for age, gender, and smoking status (β = − 0.248, p = 0.025). Further analysis showed that the negative relationship between KYN/TRP and white matter glutamate was found in both healthy controls (r = − 0.350, p = 0.036) and schizophrenia patients (r = − 0.391, p = 0.024; Figure 3), suggesting that higher tryptophan to kynurenine conversion was associated with lower glutamate level at this prefrontal white matter region, consistent with animal data found in the prefrontal cortex Konradsson-Geuken et al, 2010).…”
Section: White Matter Neurochemistrysupporting
confidence: 83%
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“…Examination of this relationship with linear regression found that the KYN/TRP still predicted white matter glutamate after controlling for age, gender, and smoking status (β = − 0.248, p = 0.025). Further analysis showed that the negative relationship between KYN/TRP and white matter glutamate was found in both healthy controls (r = − 0.350, p = 0.036) and schizophrenia patients (r = − 0.391, p = 0.024; Figure 3), suggesting that higher tryptophan to kynurenine conversion was associated with lower glutamate level at this prefrontal white matter region, consistent with animal data found in the prefrontal cortex Konradsson-Geuken et al, 2010).…”
Section: White Matter Neurochemistrysupporting
confidence: 83%
“…Kynurenine and kynurenic acid administration to the prefrontal cortex significantly decrease extracellular glutamate levels in rodents Konradsson-Geuken et al, 2010). Here, we found that in both patients and controls, KYN/TRP ratios were inversely correlated with frontal white matter glutamate.…”
Section: Discussionmentioning
confidence: 49%
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“…These are viable conditions for in vivo recording as basal glutamate concentrations a 3. With Pt nano-particles Without Pt nano-particles 3 log (Frequency (Hz)) log (Impedance (Ω)) 4 5 Figure 2 Impedance spectra of electrophysiological microelectrodes before and after Pt nanoparticles were deposited on them. The frequency range was 0.1-100 kHz, and the voltage level was +0.02 V vs. Ag|AgCl reference electrode.…”
Section: Glutamate Calibrationmentioning
confidence: 99%
“…Abnormal transmission of glutamate can cause neurological diseases such as communication dysfunction, cognitive impairments, schizophrenia, Parkinson's disease, stroke and epilepsy 4,5 . Glutamate transformation in excitatory and neurovirulent processes has been studied for decades [6][7][8][9][10][11] .…”
Section: Introductionmentioning
confidence: 99%