Cortical Mapping of 3D Optical Topography in Infants

Abstract

Precise localization of cortical activation in the early development of the infant brain remains unclear. It is challenging to co-register haemodynamic responses during functional activation in infants with the underlying anatomy of the brain. We used a multispectral imaging algorithm to reconstruct 3D optical topographic images of haemodynamic responses in an infant during voice processing. In this paper we present a method for co-registering 3D optical topography images reconstructed from functional activation data in infants onto anatomical brain images obtained from MRI structurals of the individual infants.

Construction and validation of a database of head models for functional imaging of the neonatal brain

“…In the last two decades, a large body of research applying DOT to the study of the neonatal brain has been established, such as studies of functional activation (Austin et al, 2006; Hebden, 2003; Karen et al, 2019; White, Liao, Ferradal, Inder, & Culver, 2012), neuropathology (Chalia et al, 2016; Dempsey et al, 2014; Plomgaard et al, 2016; Singh et al, 2016), and monitoring the brain for extended periods (Brigadoi et al, 2019). Previous work with infants has also employed prior structural information as a space to which functional data can be registered (Papademetriou et al, 2013).…”