Cortical thickness in bipolar disorder: a systematic review

Hanford, Lindsay; Nazarov, Anthony; Hall, Geoffrey B.; Sassi, Roberto

doi:10.1111/bdi.12362

Cited by 189 publications

(149 citation statements)

References 108 publications

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“…35 Furthermore, longitudinal voxel-and tensor-based morphometric studies support an association between depressive episodes and frontal and temporal gray matter (GM) loss in BD 36,37 and MDD. 5 Although the mechanisms underlying the potential lateralization effects of BD remain unknown, genes involved in handedness and language lateralization were associated with depression and BD in a recent study. 14,36,37 Moreover, thinner left temporal cortices is one of the most consistent findings across cortical thickness studies in BD.…”

Section: Discussionmentioning

confidence: 99%

“…3 Although the neural underpinnings of illness progression remain poorly understood, it has been suggested that mood episodes can cause lasting neurobiological alterations. 5,6 These cortical regions are believed to play central roles in processing and regulation of emotions. 5,6 These cortical regions are believed to play central roles in processing and regulation of emotions.…”

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confidence: 99%

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Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II

et al. 2019

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| INTRODUC TI ONBipolar disorder (BD) is a chronic psychiatric illness characterized by episodic disturbances in mood and activity levels and affects 2%-3% of the population worldwide. 1 BD type I is defined by at least one manic episode, while BD type II is characterized by alternating episodes of hypomania and depression. The clinical significance of both subtypes is comparable in terms of illness burden, role impairments, AbstractObjectives: Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes in cortical thickness between individuals with BD type II and healthy controls (HCs), and examined the effect of mood episodes on cortical thickness change.Methods: Thirty-three HCs and 29 individuals with BD type II underwent 3T magnetic resonance imaging at baseline, as published previously, and 2.4 years later, at follow-up. Cross-sectional and longitudinal analyses of cortical thickness were performed using Freesurfer, and relationships with mood episodes from baseline to follow-up were assessed.Results: Individuals with BD type II had thinner left and right prefrontal and left temporal cortex clusters at follow-up (all corrected P < 0.001), consistent with baseline results. Both groups showed widespread longitudinal cortical thinning, and patients had increased thinning in a left temporal cortex cluster compared to HCs (corrected P < 0.001). Patients with more (>2) depressive episodes between baseline and followup had greater left temporal cortical thinning than patients with fewer depressive episodes (corrected P < 0.05). In addition, patients with more depressive episodes had greater thinning in bilateral ventromedial prefrontal clusters relative to HCs (uncorrected P < 0.05), yet these results did not survive correction for multiple comparisons. Conclusions:Together, these findings support reduced frontotemporal cortical thickness in BD type II and provide the first preliminary evidence for an association between depressive episodes and increased cortical thinning. K E Y W O R D Sbipolar disorder, cortical thickness, cortical thinning, depressive episodes, longitudinal study, progressive changes

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II

et al. 2019

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“…[26][27][28] In adults, a recent systematic review of studies examining cortical thickness showed that BD was associated with cortical thinning, predominantly in the left anterior cingulate cortex, left superior temporal gyrus and bilateral PFC. 29 In contrast, a meta-analysis of studies examining regional volumes in adults concluded that, besides right lateral ventricular enlargement, no other regional volumes were significantly different in individuals with BD. 30 Overlapping findings between youth and adult cortical thickness studies, but mixed findings between youth and adult volumetric studies, suggest volume and cortical thickness may follow different neurodevelopmental trajectories.…”

Section: Introductionmentioning

confidence: 98%

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder

Islam

Metcalfe

MacIntosh

et al. 2018

jpn

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“…Several studies of BD patients reported subtle but widespread CT abnormalities and showed decreased CT in the left anterior cingulate/paracingulate, left superior temporal gyrus and prefrontal regions (Rimol et al, 2010, Rimol et al, 2012, Hanford et al, 2016). And several studies of MDD patients reported reduced CT in the medial orbitofrontal gyrus and pars opercularis (van Eijndhoven et al, 2013, Tu et al, 2012), and a study reported increased CT in similar regions (Qiu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders

et al. 2017

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Major depressive disorder (MDD) and bipolar disorder (BD) are severe psychiatric diseases with overlapping symptomatology. Although previous studies reported abnormal brain structures in MDD or BD patients, the disorder-specific underlying neural mechanisms remain poorly understood. The purpose of this study was to investigate the whole-brain gray matter morphological patterns in unmedicated patients with MDD or BD and to identify the shared and disease-specific brain morphological alterations in these two disorders.We acquired high-resolution brain structural MRI data from a sample of 36 MDD patients, 32 BD patients, and 30 healthy controls. Using FreeSurfer, we estimated their brain cortical thickness (CT) and compared between-group difference in multiple locations across the continuous cortical surface.Compared to the healthy controls, both the MDD and BD patient groups showed significantly reduced CT in the left inferior temporal cortex (ITC). However, compared to the MDD patients, the BD patients showed a significantly thinner CT in the left rostral middle frontal region. In addition, compared to the healthy controls, the BD patients displayed thinner CT in the left ITC, left frontal pole (FPO), left superior frontal, right lateral occipital, right pars triangularis (PTRI) and right lateral orbitofrontal regions. Further analysis revealed a significantly positive correlation between the mean CT in the left FPO and the onset age, but a negative correlation between the mean CT in the right PTRI and the number of episodes, in the BD patients.Our findings revealed that the BD and MDD patients had variations in CT that were in common, but many more that were distinct, suggesting potential differences in their neural mechanisms.

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Cortical thickness in bipolar disorder: a systematic review

Abstract: This systematic review further supports a link between specific structural brain abnormalities and BD. Future studies should investigate cortical thickness with respect to at-risk populations to determine whether these neuropathologies develop before or after the onset of BD.

Cited by 189 publications

References 108 publications

Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II

Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder

Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders

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