Cortico-cortical evoked potentials for sites of early versus late seizure spread in stereoelectroencephalography

Lega, Bradley; Dionisio, Sasha; Flanigan, Patrick M.; Bingaman, William; Najm, Imad; Nair, Dileep; González-Martínez, Jorge

doi:10.1016/j.eplepsyres.2015.04.009

Cited by 38 publications

(36 citation statements)

References 52 publications

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“…In CCEPs, stimulation frequencies such as 1 Hz, 0.5 Hz, 0.33 Hz, 0.2 Hz, 0.1 Hz, and 0.067 Hz have been used in the past (Table ). Only one study has looked at effects of stimulation frequency on response morphology— little difference in responses to 2 and 1 Hz stimulation in Heschl's gyrus was shown; however, there was a marked change between 2 and 5 Hz …”

Section: Physical Stimulation Considerationsmentioning

confidence: 99%

“…However, this must be weighed against the increased SNR that may be obtained by a higher number of trials. Many studies use 20‐30 pulses in each pulse train; as few as 10 pulses have also been used . Because the SNR is unknown at all sites in SEEG, the number of pulses in a train should be as high as practically possible within the timeframe of the stimulation session, while carefully considering the clinical situation and total stimulation time.…”

Section: Physical Stimulation Considerationsmentioning

confidence: 99%

“…Further filtering to attenuate powerline or other artifacts is frequently performed using digital filters, of which there are two main variants: finite impulse response (FIR) filters, which are purely digital, and infinite impulse response (IIR), which are modeled from analog counterparts. Researchers have used IIR filters, as they are more computationally efficient and quick to process . However, nonlinear delays are applied to signals, and must therefore be forward and reverse filtered, especially if time frequency metrics or metrics that use phase are to be used.…”

Section: Postprocessing Considerationsmentioning

confidence: 99%

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Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

2017

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SummaryThis review aims to highlight key considerations when performing cortico-cortical evoked potentials (CCEPs) using stereo-electroencephalography (SEEG) for network mapping and show its clinical applicability to presurgical evaluations. The parameters for performing stimulation and safety aspects have been investigated in electrocorticography (ECoG) and deep brain stimulation (DBS), but not as extensively in SEEG. A review of current literature was performed, with an attempt made to emphasize practical insights from all modalities of intracranial stimulation. This paper reviews physical stimulation parameters, highlights safety limits, and considers the influence of changing common stimulation parameters.These factors are put into the context of CCEPs in SEEG. Given the paucity of direct research in this area, studies utilizing low frequency stimulation, DBS, and ECoG are incorporated along with the fundamental principles of electrical engineering. In addition, postprocessing considerations are reviewed, including electrode localization, application of digital filters, baseline selection, application of connectivity metrics, and higher order network analysis. The aim is to guide CCEP stimulation as well as to provide an understanding of the underlying principles of this technique. At present, there are few articles detailing the design of low-frequency stimulation paradigms, especially in the setting of SEEG. Providing a review of the fundamentals and postprocessing considerations when performing CCEPs in SEEG will increase the accessibility of this technique. K E Y W O R D Sbrain mapping, CCEP, connectivity, electrical stimulation, review, SEEG

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Section: Physical Stimulation Considerationsmentioning

confidence: 99%

Section: Physical Stimulation Considerationsmentioning

confidence: 99%

Section: Postprocessing Considerationsmentioning

confidence: 99%

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Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

2017

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“…We deliberately focus our attention on research assessing how a non-invasive perturbation of local neural activity can alter the dynamics of the whole brain. Although they present obvious advantages such as exquisite spatial and temporal resolution, invasive studies assessing the widespread impact of altered local activity were omitted because of their inability to comprehensively assess whole-brain changes in neural system dynamics Keller et al, 2011;Keller et al, 2014;Lega et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Mapping how local perturbations influence systems-level brain dynamics

2017

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The human brain exhibits a relatively stable spatiotemporal organization that supports brain function and can be manipulated via local brain stimulation. Such perturbations to local cortical dynamics are globally integrated by distinct neural systems. However, it remains unclear how and why local changes in neural activity affect large-scale system dynamics. Here, we briefly review empirical and computational studies addressing how localized perturbations affect brain activity. We then systematically analyze a model of large-scale brain dynamics, assessing how localized changes in brain activity at the different sites affect whole-brain dynamics. We find that local stimulation induces changes in brain activity that can be summarized by relatively smooth tuning curves, which relate a region's effectiveness as a stimulation site to its position within the cortical hierarchy. Our results also support the notion that brain hubs, operating in a slower regime, are more resilient to focal perturbations and critically contribute to maintain stability in global brain dynamics. In contrast, perturbations of peripheral regions, characterized by faster activity, have greater impact on functional connectivity. As a parallel with this region-level result, we also find that peripheral systems such as the visual and sensorimotor networks were more affected by local perturbations than high-level systems such as the cingulo-opercular network. Our results highlight the importance of a periphery-tocore hierarchy to determine the effect of local stimulation on the brain network. We also provide novel resources to orient empirical work aiming at manipulating functional connectivity using noninvasive brain stimulation.3

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“…However, "early spread' proved to be useful in clinical application [18]. Stimulation elicited enhanced gamma band activity at early spread sites, which was highly coherent with the onset zone [19]. Latencies of spread maybe related to the degree of integrity of inhibition in these areas, with early spread as a possible indicator of secondary epileptogenesis [20].…”

Section: Extratemporal Early Propagations In Atypical Tlementioning

confidence: 99%

Evaluating the Prognosis of Surgical Treatment in Atypical Temporal Lobe Epilepsy-A Study Based on Ictal Onset Patterns and Extratemporal Early Propagations on Stereo-Electroencephalography

Wang¹,

Li²,

Wang³

et al. 2017

Neuropsychiatry

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Purpose:Our aim is to examine ictal onset patterns (IOPs), extratemporal early propagations (EPs) and inner relationship between them based on stereo-electroencephalography recordings in the patients with atypical temporal lobe epilepsy, and to evaluate their impact on seizure prognosis and cognitive outcomes after epilepsy surgery. Methods:Forty-three patients were included in this retrospective study. Five to sixteen multilead electrodes were implanted per patient. All of them underwent a standard craniotomy for tailored resection of the hypothetical epileptogenic zone. Post-operative seizure status and cognitive outcomes were evaluated by Engle's classification, Wechsler intelligence and Wechsler memory scale. Results:Four types of IOPs were identified in the 43 patients. The patients with low frequency highamplitude periodic spikes (LFPS) and spike or poly-spike fast discharges (SpFD) had better seizure outcomes. There were ten patients with extratemporal EPs, who had worse clinical outcomes than those without extratemporal EPs (Engel's class I: χ2 =10.689, p=0.001; Engel's class Ia: χ2 =4.251, p=0.039). Three conditions related to IOPs and extratemporal EPs were combined to predict the seizure prognosis after operation. The sensitivity and specificity were 90.0% and 78.6% for Engel's class I, and were 87.0% and 55.0% for Engel's class Ia. The patients with LFPS showed more significant improvement in memory quotient (MQ) but not in full intelligence quotient (FIQ) than those with other IOPs. Conclusions:IOPs and extratemporal EPs are closely related to seizure status and cognitive outcomes after epilepsy surgery in atypical TLE patients.

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Cortico-cortical evoked potentials for sites of early versus late seizure spread in stereoelectroencephalography

Cited by 38 publications

References 52 publications

Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

Considerations in performing and analyzing the responses of cortico‐cortical evoked potentials in stereo‐EEG

Mapping how local perturbations influence systems-level brain dynamics

Evaluating the Prognosis of Surgical Treatment in Atypical Temporal Lobe Epilepsy-A Study Based on Ictal Onset Patterns and Extratemporal Early Propagations on Stereo-Electroencephalography

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