Corticosteroid induced lambing in the ewe

Emady, M; Noakes, D.E.; Hadley, J. C.; Arthur, GH

doi:10.1136/vr.95.13.281

Cited by 8 publications

(4 citation statements)

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“…However, although there seem to be positive correlations between total placental weight, maximum oPL concentrations and mammary weight over several litter sizes, the situation within a particular litter size is apparently less consistent (H. Wright and D. J. Mellor, unpublished results), which suggests that other factors cause variations in mammary growth within ranges set by the level of oPL secretion. One of these factors might be placental progesterone; it is secreted in large amounts during the last half of pregnancy, its plasma concentrations increase as litter size increases and it has mammogenic properties (Bassett et al 1969;Emardy et al 1974;Ricketts & Flint, 1980;Knight & Peaker, 1982). However, its precise effects on mammary growth have not been quantified.…”

Section: Fetalgrowth Patternsmentioning

confidence: 99%

Nutritional effects on the fetus and mammary gland during pregnancy

Mellor

1987

Proc. Nutr. Soc.

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Section: Fetalgrowth Patternsmentioning

confidence: 99%

Nutritional effects on the fetus and mammary gland during pregnancy

Mellor

1987

Proc. Nutr. Soc.

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“…Corticosteroids have been used to induce lambing in ewes when given late in gestation. Different forms of corticosteroids such as dexamethasone (Bosc, 1972;Joyce, 1974;Shevah, 1974); flumethasone (Emadi & Noakes, 1973;Emadi et al 1974;Harman & Slyter, 1980) or betamethasone (Lucas & Notman, 1974) have been used with varying levels of success. It has been well documented that there is a sharp rise in oestrogens in the maternal circulation just prior to parturition (Challis, 1971;Challis, Harrison & Heap, 1971;Obst & Seamark, 1972).…”

Section: Introductionmentioning

confidence: 99%

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Boland¹,

Crosby²,

Gordon³

1982

J. Agric. Sci.

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In the first of two experiments 45 ewes were treated on day 141 of gestation with either prostaglandin F 2 a or saline. Doses of 10, 15, 20 or 25 mg PGF 2a failed to induce lambing earlier than in control animals. A further 50 ewes were similarly treated on day 144; neither dose level of PGF aa nor day of administration had any effect on the interval from injection to lambing compared with controls. In a second experiment 159 ewes were randomly assigned to one of four treatment groups as follows: (1) 20 mg oestradiol benzoate (ODB); (2) 16 mg dexamethasone; (3) 15 mg PGF 2a ; (4) 2 ml saline. Ewes were injected on either day 143 or 144 of gestation and on each of those days animals were injected either in the morning or evening. The mean times to induction of lambing were 38-6 + 20-8; 44-2+18-1; 83-5±39-8 and 82-9±43-lh for the four treatments respectively. Neither day nor time of treatment had any significant effect on the interval to lambing. Both ODB and dexamethasone induced parturition earlier than PGF 2a or saline (P < 005).

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“…IP with 16 mg of dexamethasone at the 141st gestation day has shown MIs of 45 ± 8.4 hours (22). The MIs were 115.10 ± 32.62 and 56.25 ± 11.62 hours following IP with 1 and 2.5 mg of corticosteroids at the 138th gestation day, respectively (18). The MI was 98.66 ± 31.55 hours in GR II after IP with 16 mg of dexamethasone.…”

Section: Discussionmentioning

confidence: 96%

“…In ewes, IP at the 138th gestation day results in uncomplicated birth and non-premature lambs (18,26,34). Although IP at this gestation time point is not preferred by some authors due to premature birth (1, 30), many studies have investigated the timing of IP before the 138th gestation day (26,40).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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SummaryObjective: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. Materials and methods: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA. Results: A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II. Conclusion and clinical relevance: Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for IP.

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Corticosteroid induced lambing in the ewe

Cited by 8 publications

References 0 publications

Nutritional effects on the fetus and mammary gland during pregnancy

Nutritional effects on the fetus and mammary gland during pregnancy

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

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