Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio

Stolte, Ellen H.; Mazon, A.F.; Leon-Koosterziel, Karen M; Jesiak, Maria; Bury, Nicolas R.; Sturm, Armin; Savelkoul, H.F.J.; Kemenade, B.M.L. Verburg-van; Flik, G.

doi:10.1677/joe-08-0100

Cited by 158 publications

(119 citation statements)

References 48 publications

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“…However, MR receptors were recently described in common carp (Prunet et al, 2006;Stolte et al, 2008). Transactivation studies show that both receptors have similar affinities to cortisol, despite the main MR ligand is still not entirely defined (Stolte et al, 2008). Expression of GRs and MRs mRNA was found in the forebrain (especially in the lateral pallium) and in all relevant neuroendocrine components of the HPI axis, in a very similar pattern to that described in other vertebrates (De Kloet et al, 2005;Stolte et al, 2008).…”

Section: The Hpi Axis Responsesupporting

confidence: 62%

“…Until recently, teleosts were thought to have only GR receptors with both osmotic and stressrelated functions (Mommsen et al, 1999). However, MR receptors were recently described in common carp (Prunet et al, 2006;Stolte et al, 2008). Transactivation studies show that both receptors have similar affinities to cortisol, despite the main MR ligand is still not entirely defined (Stolte et al, 2008).…”

Section: The Hpi Axis Responsementioning

confidence: 99%

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<b>Psychological Stress and Welfare in Fish</b>

Galhardo¹,

Oliveira²

2009

Annu Rev Biomed Sci

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Galhardo L, Oliveira RF. Psychological Stress and Welfare in Fish. Annu Rev Biomed Sci 2009;11:1-20. The ability to respond to stress is vital to the survival of any living organism, though sustained reactions can become detrimental to the health and welfare of animals. Stress responses of vertebrates are known through several studies in their physiological, behavioural and psychological components, under acute and chronic contexts. In fish, the physiological and behavioural aspects of stress are considerably well known phenomena and show striking similarities to those of other vertebrates. However, the psychological component is not well known. Some authors deny mental experiences to fish on the basis of their lack of neocortex. Nevertheless, recent studies have shown neuroendocrine, cognitive and emotional processes in fish that are not only equivalent to other vertebrates, but also allow inferring some forms of mental representation. The integration of psychological elements in fish stress physiology is insufficiently studied, but, as discussed in this article, there is already indirect evidence to admit that some form of stimuli appraisal can take place in fish. This fact has profound implications on the regulation of the stress response, as well as on fish welfare and its management.

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Section: The Hpi Axis Responsesupporting

confidence: 62%

Section: The Hpi Axis Responsementioning

confidence: 99%

<b>Psychological Stress and Welfare in Fish</b>

Galhardo¹,

Oliveira²

2009

Annu Rev Biomed Sci

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“…The EC50 of F is 0.02 nM for cichlid (Greenwood et al 2003, 1).1 nM for trout (Sturm et al 2005, 2).4 nM for carp (Stolte et al 2008) and 0.22 nM for zebrafish (Pippal et al 2011).…”

Section: Ser-843 In Human Mr: Role In Divergence From the Grmentioning

confidence: 99%

“…11βHSD2 first appears in Chondrichthyes , Rossier et al 2015, in which 11βHSD2 may regulate access of B to the MR. Although Aldo is not found in ray-finned fish, Aldo is a strong transcriptional activator of fish MR (Greenwood et al 2003, Sturm et al 2005, Stolte et al 2008, Pippal et al 2011, Sugimoto et al 2016. Indeed, the physiological mineralocorticoid in ray-finned fish is not fully understood because several 3-ketosteroids, including F, DOC, B, S and Prog are transcriptional activators of the MR (Greenwood et al 2003, Sturm et al 2005, Stolte et al 2008, Pippal et al 2011, Sugimoto et al 2016, and one or more of these steroids could be a physiological mineralocorticoid.…”

Section: Introductionmentioning

confidence: 99%

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Evolution of the mineralocorticoid receptor: sequence, structure and function

Baker

Katsu

2017

Journal of Endocrinology

119

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The mineralocorticoid receptor (MR) is descended from a corticoid receptor (CR), which has descendants in lamprey and hagfish, cyclostomes (jawless fish), a taxon that evolved at the base of the vertebrate line. A distinct MR and GR first appear in cartilaginous fishes (Chondrichthyes), such as sharks, skates, rays and chimeras. Skate MR has a strong response to corticosteroids that are mineralocorticoids and glucocorticoids in humans. The half-maximal responses (EC50s) for skate MR for the mineralocorticoids aldosterone and 11-deoxycorticosterone are 0.07 nM and 0.03 nM, respectively. EC50s for the glucocorticoids cortisol and corticosterone are 1 nM and 0.09 nM, respectively. The physiological mineralocorticoid in ray-finned fish, which do not synthesize aldosterone, is not fully understood because several 3-ketosteroids, including cortisol, 11-deoxycortisol, corticosterone, 11-deoxycorticosterone and progesterone are transcriptional activators of fish MR. Further divergence of the MR and GR in terrestrial vertebrates, which synthesize aldosterone, led to emergence of aldosterone as a selective ligand for the MR. Here, we combine sequence analysis of the CR and vertebrate MRs and GRs, analysis of crystal structures of human MR and GR and data on transcriptional activation by 3-ketosteroids of wild-type and mutant MRs and GRs to investigate the evolution of selectivity for 3-ketosteroids by the MR in terrestrial vertebrates and ray-finned fish, as well as the basis for binding of some glucocorticoids by human MR and other vertebrate MRs.

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“…Whole-genome duplication in the teleost lineage w350 MYA gave rise to two GR isoforms, GR1 and GR2, with an identical domain structure and many similarities in terms of ligand-and DNA-binding (reviewed by Bury & Sturm (2007) and Li et al (2012)). Differential tissue mRNA expression levels and regulation of expression (Greenwood et al 2003, Stolte et al 2008a, Kiilerich et al 2011a, Trayer et al 2013, together with dissimilar EC 50 values for cortisol (Bury et al 2003, Greenwood et al 2003, Stolte et al 2008b, Kim et al 2011, Li et al 2012, suggest functional differences between these two GR subtypes.…”

mentioning

confidence: 99%

Interaction between the trout mineralocorticoid and glucocorticoid receptors in vitro

Kiilerich¹,

Triqueneaux²,

Christensen³

et al. 2015

Journal of Molecular Endocrinology

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The salmonid corticosteroid receptors (CRs), glucocorticoid receptors 1 and 2 (GR1 and GR2) and the mineralocorticoid receptor (MR) share a high degree of homology with regard to structure, ligand-and DNA response element-binding, and cellular co-localization. Typically, these nuclear hormone receptors homodimerize to confer transcriptional activation of target genes, but a few studies using mammalian receptors suggest some degree of heterodimerization. We observed that the trout MR confers a several fold lower transcriptional activity compared to the trout GRs. This made us question the functional relevance of the MR when this receptor is located in the same cells as the GRs and activated by cortisol. A series of co-transfection experiments using different glucocorticoid response elements (GREs) containing promoter-reporter constructs were carried out to investigate any possible interaction between the piscine CRs. Co-transfection of the GRs with the MR significantly reduced the total transcriptional activity even at low MR levels, suggesting interaction between these receptors. Co-transfection of GR1 or GR2 with the MR did not affect the subcellular localization of the GRs, and the MR-mediated inhibition seemed to be independent of specific activation or inhibition of the MR. Site-directed mutagenesis of the DNA-binding domain and dimerization interface of the MR showed that the inhibition was dependent on DNA binding but not necessarily on dimerization ability. Thus, we suggest that the interaction between MR and the GRs may regulate the cortisol response in cell types where the receptors co-localize and propose a dominant-negative role for the MR in cortisolmediated transcriptional activity.

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Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio

Cited by 158 publications

References 48 publications

<b>Psychological Stress and Welfare in Fish</b>

<b>Psychological Stress and Welfare in Fish</b>

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Evolution of the mineralocorticoid receptor: sequence, structure and function

Interaction between the trout mineralocorticoid and glucocorticoid receptors in vitro

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